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公开(公告)号：US20050032065A1
公开(公告)日：2005-02-10
申请号：US10603505
申请日：2003-06-24
申请人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
发明人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , Y02A90/26
摘要： The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.
摘要翻译： 本发明将经典生存分析应用于前列腺癌患者的前列腺癌基因组全基因表达谱和术前前列腺特异性抗原水平，以鉴定提供相对于前列腺特异性抗原浓度的额外预测值的疾病复发的预后标志物。 本发明提供一种确定前列腺癌的预后并预测患者的前列腺癌预后的方法。 该方法包括首先建立至少一种前列腺癌预后基因的阈值的步骤。 然后，确定来自前列腺癌患者的前列腺组织的预后基因的量。 将该患者中存在的预后基因的量与预后基因的既定阈值进行比较，从而确定患者的预后结果。
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公开(公告)号：US20070099197A1
公开(公告)日：2007-05-03
申请号：US11365745
申请日：2006-02-28
申请人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
发明人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , Y02A90/26
摘要： The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.
摘要翻译： 本发明将经典生存分析应用于前列腺癌患者的前列腺癌基因组全基因表达谱和术前前列腺特异性抗原水平，以鉴定提供相对于前列腺特异性抗原浓度的额外预测值的疾病复发的预后标志物。 本发明提供一种确定前列腺癌的预后并预测患者的前列腺癌预后的方法。 该方法包括首先建立至少一种前列腺癌预后基因的阈值的步骤。 然后，确定来自前列腺癌患者的前列腺组织的预后基因的量。 将该患者中存在的预后基因的量与预后基因的既定阈值进行比较，从而确定患者的预后结果。
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公开(公告)号：US20090233286A1
公开(公告)日：2009-09-17
申请号：US12288676
申请日：2008-10-22
IPC分类号： C12Q1/68
CPC分类号： G01N33/57438 , A61K38/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N2800/52
摘要： Disclosed herein are methods of diagnosing pancreatic cancer in a subject. Also provided are methods of monitoring the efficacy of a therapeutic treatment of pancreatic cancer as well as methods of determining the likelihood that a subject having pancreatic cancer will survive, and methods of determining the suitability of a subject having pancreatic cancer for surgical resection therapy.
摘要翻译： 本文公开了诊断受试者中胰腺癌的方法。 还提供了监测胰腺癌治疗治疗效果的方法以及确定胰腺癌患者可能存活的可能性的方法以及确定具有胰腺癌的受试者适合手术切除治疗的方法。
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公开(公告)号：US20060269921A1
公开(公告)日：2006-11-30
申请号：US10548460
申请日：2004-02-18
IPC分类号： C12Q1/68
CPC分类号： G01N33/57438 , A61K38/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N2800/52
摘要： The present invention provides novel genes and proteins for diagnosing pancreatic cancer and/or a likelihood for survival e.g., following surgical resection, wherein the expression of the genes and proteins is up-regulated or down-regulated. The pancreatic cancer-associated genes and proteins of the invention are specifically exemplified by the genes and proteins set forth in Tables 3 to 25 and the Sequence Listing.
摘要翻译： 本发明提供用于诊断胰腺癌和/或存活可能性的新型基因和蛋白质，例如在手术切除术之后，其中基因和蛋白质的表达被上调或下调。 本发明的胰腺癌相关基因和蛋白质由表3至25和序列表中列出的基因和蛋白质具体举例说明。
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公开(公告)号：US20070054268A1
公开(公告)日：2007-03-08
申请号：US10526979
申请日：2003-09-05
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , Y02A90/26
摘要： The present invention provides novel genes and proteins for diagnosing ovarian cancer and/or a likelihood for survival, or recurrence of disease, wherein the expression of the genes and proteins is up-regulated or down-regulated or associated with the occurrence or recurrence of a specific scanner sub-type. The ovarian cancer-associated genes and proteins of the invention are specifically exemplified by the genes and proteins set forth in Tables 1 to 3 and the Sequence Listing.
摘要翻译： 本发明提供用于诊断卵巢癌的新基因和蛋白质和/或存活或疾病复发的可能性，其中基因和蛋白质的表达被上调或下调或与发生或复发相关 特定扫描仪子类型。 本发明的卵巢癌相关基因和蛋白质由表1至表3和序列表中列出的基因和蛋白质具体举例说明。
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公开(公告)号：US20060137029A1
公开(公告)日：2006-06-22
申请号：US11218716
申请日：2005-09-06
IPC分类号： C12Q1/68 , G01N33/574 , A01K67/027 , C07H21/04 , C12P21/06 , C07K14/71 , C07K16/30
CPC分类号： C07K14/723 , A01K2217/05 , C07K14/705 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , G01N33/57449 , G01N33/76
摘要： The present invention provides GPR56 genes and polypeptides encoded therefor. The GPR56 genes of the invention are expressed highly in malignant tissues and the invention also provides diagnostic processes for detecting cancer or malignant tumors in human subjects The diagnostic and prognostic test of the present invention is particularly useful for the early detection of ovarian cancer or metastases thereof and for monitoring the progress of disease, such as, for example, during remission or following surgery or chemotherapy. The GPR56 gene of the invention is also expressed in effector memory T cells, and the invention therefor provides methods of identifying and/or quantifying effector memory T cells, which methods are useful for determining the immune status of a subject.
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公开(公告)号：US20070178458A1
公开(公告)日：2007-08-02
申请号：US10570649
申请日：2003-09-05
IPC分类号： C12Q1/68
CPC分类号： C07H21/04 , C07K14/4748 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Q2600/178 , G01N33/57449 , G01N2800/52
摘要： The present invention provides novel genes and proteins for diagnosing ovarian cancer and/or a likelihood for survival, or recurrence of disease, wherein the expresson of the genes and proteins is up-regulated or down-regulated or associated with the occurrence or recurrence of a specific cancer sub-type. The ovarian cancer-associated genes and proteins of the invention are specifically exemplified by the genes and proteins set forth in Tables 1 to 5 and the Sequence Listing.
摘要翻译： 本发明提供用于诊断卵巢癌的新基因和蛋白质和/或存活或疾病复发的可能性，其中所述基因和蛋白质的表达被上调或下调或与发生或复发相关 特异性癌症亚型。 本发明的卵巢癌相关基因和蛋白质由表1至5和序列表中列出的基因和蛋白质具体举例说明。
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公开(公告)号：US20060147922A1
公开(公告)日：2006-07-06
申请号：US10526905
申请日：2003-09-05
申请人： Colin Watts , Darren Saunders , Michelle Henderson , Jennifer Clancy , Susan Henshall , Robert Sutherland , Philippa O'Brien
发明人： Colin Watts , Darren Saunders , Michelle Henderson , Jennifer Clancy , Susan Henshall , Robert Sutherland , Philippa O'Brien
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , Y02A90/26
摘要： This invention provides novel methods of detecting or treating aberrant cell cycle regulation associated with expression of a nuclear protein encoded by a gene that is linked to map position 8q22.3 of the human genome, and to novel reagents that are useful therefor. More particularly, the invention provides novel nucleic acid and proteinaceous probes, for detecting a gene that is linked to map position 8q22.3 of the human genome or the expression products thereof, wherein expression or elevated expression of said gene is associated with the appearance or occurrence of tumors associated with cancer, DNA damage and progesterone-receptor-mediated effects on cells. The invention also provides reagents and methods for detecting or modulating the expression products of the gene, such as, for example, in the diagnosis or treatment of cancer, cellular proliferation, DNA damage or progesterone receptor-mediated effects on cells.
摘要翻译： 本发明提供了检测或治疗与由人基因组的图谱位置8q22.3连接的基因编码的核蛋白的表达相关的异常细胞周期调节的新方法，以及对其有用的新型试剂。 更具体地，本发明提供新的核酸和蛋白质探针，用于检测与人基因组的图8q22.3的表达或其表达产物连接的基因，其中所述基因的表达或升高的表达与外观或 与癌症相关的肿瘤的发生，DNA损伤和孕激素受体介导的对细胞的作用。 本发明还提供用于检测或调节基因的表达产物的试剂和方法，例如在癌症的诊断或治疗中，细胞增殖，DNA损伤或孕酮受体介导的对细胞的作用。
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