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1.发明授权Antibodies for the detection of Bacillus anthracis and vaccine against B. anthracis infections 失效用于检测炭疽芽孢杆菌和针对炭疽杆菌感染的疫苗的抗体公开(公告)号：US07901687B2
公开(公告)日：2011-03-08
申请号：US12226728
申请日：2007-04-27
CPC分类号： A61K39/07 , A61K47/646 , A61K2039/6081
摘要： The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis.
摘要翻译： 本发明涉及式1的寡糖的缀合物，其中R是与载体蛋白质的接头，并且任选地包含多达三个其它的糖类，其可用于疫苗接种，合成这种缀合物的方法，针对该抗原的抗体， 产生针对该抗原的单克隆抗体的杂交瘤，使用这些抗体检测炭疽芽孢杆菌的试验和包含这些抗体的试剂盒，以及用于预防炭疽杆菌感染的疫苗，其包含式1的寡糖的缀合物。单克隆抗体10 本发明选择性地结合炭疽杆菌，但不涉及相关细菌如枯草芽孢杆菌，蜡状芽孢杆菌和该组其他细菌如苏云金芽孢杆菌。
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2.发明申请Antibodies for the Detection of Bacillus Anthracis and Vaccine Against B. Anthracis Infections 失效用于检测炭疽芽孢杆菌和疫苗对抗炭疽杆菌感染的抗体公开(公告)号：US20090155299A1
公开(公告)日：2009-06-18
申请号：US12226728
申请日：2007-04-27
IPC分类号： A61K39/07 , C07K16/18 , C12N5/06 , G01N33/569 , C07K2/00
CPC分类号： A61K39/07 , A61K47/646 , A61K2039/6081
摘要： The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis.
摘要翻译： 本发明涉及式1的寡糖的缀合物，其中R是与载体蛋白质的接头，并且任选地包含多达三个其它的糖类，其可用于疫苗接种，合成这种缀合物的方法，针对该抗原的抗体， 产生针对该抗原的单克隆抗体的杂交瘤，使用这些抗体检测炭疽芽孢杆菌的试验和包含这些抗体的试剂盒，以及用于预防炭疽杆菌感染的疫苗，其包含式1的寡糖的缀合物。单克隆抗体10 本发明选择性地结合炭疽杆菌，但不涉及相关细菌如枯草芽孢杆菌，蜡状芽孢杆菌和该组其他细菌如苏云金芽孢杆菌。
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