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公开(公告)号：US6126919A
公开(公告)日：2000-10-03
申请号：US797803
申请日：1997-02-07
申请人： James S. Stefely , David W. Schultz , Luke E. Schallinger , Craig A. Perman , Chester L. Leach , Daniel C. Duan
发明人： James S. Stefely , David W. Schultz , Luke E. Schallinger , Craig A. Perman , Chester L. Leach , Daniel C. Duan
CPC分类号： A61K9/0075 , A61K47/482 , A61K9/008 , A61K9/1647
摘要： Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula --[X--R.sup.1 --C(O)]-- wherein each R.sup.1 is an independently selected organic group that links the --X-- group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.
摘要翻译： 方法，化合物和利用生物相容性聚合物递送药物的药物制剂，特别是用于增溶，稳定和/或从局部，可植入和吸入系统中持续释放药物。 许多方法，化合物和药物制剂特别适用于口服和/或鼻吸入并使用下式的聚合物 - [X-R 1 -C（O）] - ，其中每个R 1是独立选择的有机基团，其连接 -X-基团，并且每个X独立地为氧，硫或链状氮。
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2.发明授权Biocompatible compounds for sustained release pharmaceutical drug delivery systems 失效用于持续释放药物输送系统的生物相容性化合物公开(公告)号：US07687054B2
公开(公告)日：2010-03-30
申请号：US10078805
申请日：2002-02-18
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/1647 , A61K47/593
摘要： Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula —[X—R1—C(O)]— wherein each R1 is an independently selected organic group that links the —X— group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.
摘要翻译： 方法，化合物和利用生物相容性聚合物递送药物的药物制剂，特别是用于增溶，稳定和/或从局部，可植入和吸入系统中持续释放药物。 许多方法，化合物和药物制剂特别适用于口服和/或鼻吸入并使用下式的聚合物 - [X-R 1 -C（O）] - ，其中每个R 1是独立选择的有机基团，其连接 -X-基团，并且每个X独立地为氧，硫或链状氮。
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公开(公告)号：US06416742B1
公开(公告)日：2002-07-09
申请号：US09634406
申请日：2000-08-09
申请人： James S. Stefely , David W. Schultz , Luke E. Schallinger , Craig A. Perman , Chester L. Leach , Daniel C. Duan
发明人： James S. Stefely , David W. Schultz , Luke E. Schallinger , Craig A. Perman , Chester L. Leach , Daniel C. Duan
IPC分类号： A61K912
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/1647 , A61K47/593
摘要： Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula —[X—R1—C(O)]— wherein each R1 is an independently selected organic group that links the —X— group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.
摘要翻译： 方法，化合物和利用生物相容性聚合物递送药物的药物制剂，特别是用于增溶，稳定和/或从局部，可植入和吸入系统中持续释放药物。 许多方法，化合物和药物制剂特别适用于口服和/或鼻吸入并使用下式的聚合物 - [X-R 1 -C（O）] - ，其中每个R 1是独立选择的有机基团，其连接 -X-基团，并且每个X独立地为氧，硫或链状氮。
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4.发明授权
公开(公告)号：US6042811A
公开(公告)日：2000-03-28
申请号：US214763
申请日：1994-03-16
CPC分类号： A61K9/008
摘要： A medicinal aerosol formulation containing a particulate drug and a diol/diacid condensate as a dispersing aid.
摘要翻译： 含有颗粒药物和二醇/二酸缩合物作为分散助剂的药用气溶胶制剂。
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5.发明授权
公开(公告)号：US5725841A
公开(公告)日：1998-03-10
申请号：US738519
申请日：1996-10-28
IPC分类号： A61K9/12 , A61K9/00 , A61K9/72 , A61K31/74 , A61K47/08 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/34 , A61L9/04 , C08G63/02 , C08G63/66
CPC分类号： A61K9/008
摘要： A medicinal aerosol formulation containing a particulate drug and a dispersing aid derived from a hydroxyacid, a mercapto acid, or an amino acid.
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6.发明授权Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid 失效含有酯，酰胺或巯基酯衍生的分散助剂的气溶胶制剂
公开(公告)号：US5569450A
公开(公告)日：1996-10-29
申请号：US213555
申请日：1994-03-16
IPC分类号： A61K9/12 , A61K9/00 , A61K9/72 , A61K31/74 , A61K47/08 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/34 , A61L9/04 , C08G63/02 , C08G63/66
CPC分类号： A61K9/008
摘要： A medicinal aerosol formulation containing a particulate drug and a dispersing aid derived from a hydroxyacid, a mercapto acid, or an amino acid.
摘要翻译： 含有颗粒药物和衍生自羟基酸，巯基酸或氨基酸的分散助剂的药用气溶胶制剂。
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7.发明授权Medicinal aerosol compositions with an amide and/or ester containing excipient compound 失效含有酰胺和/或酯的赋形剂化合物的药用气溶胶组合物公开(公告)号：US07186402B2
公开(公告)日：2007-03-06
申请号：US10327198
申请日：2002-12-20
CPC分类号： A61K9/008 , A61K9/145 , A61K47/183 , Y10S514/958
摘要： The invention comprises a medicinal aerosol composition comprising a propellant, an excipient comprising an acid or amine end-group and at least one and no more than two amide and/or ester functional groups, and a drug. The invention also comprises particulate medicinal compositions comprising particles with a mean mass aerodynamic diameter of less than about 10 microns that incorporate an excipient containing an acid or amine end-group and at least one and no more than two amide and/or ester functional groups.
摘要翻译： 本发明包括药物气溶胶组合物，其包含推进剂，包含酸或胺末端基团和至少一个且不多于两个酰胺和/或酯官能团的赋形剂和药物。 本发明还包括颗粒药物组合物，其包含具有小于约10微米的平均质量空气动力学直径的颗粒，其掺入含有酸或胺端基和至少一个且不超过两个酰胺和/或酯官能团的赋形剂。
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8.发明授权Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient 有权具有官能化聚乙二醇赋形剂的药用气溶胶组合物公开(公告)号：US07718162B2
公开(公告)日：2010-05-18
申请号：US10327200
申请日：2002-12-20
申请人： James S. Stefely , Daniel C. Duan
发明人： James S. Stefely , Daniel C. Duan
CPC分类号： A61K9/008 , A61K47/10 , A61K47/541 , A61K47/60
摘要： The invention comprises a medicinal aerosol composition comprising a propellant, an excipient comprising a functionalized polyethyleneglycol, and a drug. The invention also comprises particulate medicinal compositions comprising particles with a mean mass aerodynamic diameter of less than about 10 microns that incorporate an excipient comprising a functionalized polyethyleneglycol.
摘要翻译： 本发明包括药物气溶胶组合物，其包含推进剂，包含官能化聚乙二醇的赋形剂和药物。 本发明还包括颗粒药物组合物，其包含平均质量空气动力学直径小于约10微米的颗粒，其掺入包含官能化聚乙二醇的赋形剂。
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公开(公告)号：US09861580B2
公开(公告)日：2018-01-09
申请号：US13001630
申请日：2009-06-22
IPC分类号： B05D1/28 , A61K9/14 , A61K9/00 , A61K31/137
CPC分类号： A61K9/143 , A61K9/0075 , A61K9/146 , A61K31/137
摘要： A method of making active pharmaceutical ingredient particles with surface-modified nanoparticles deposited on the particles' surfaces, the method comprising: providing a plurality of media particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; mixing the plurality of media particles with the active ingredient particles, both of which are in dry form, to provide active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces; and separating the plurality of media particles from the active ingredient particles having surfaces with the surface-modified nanoparticles deposited on the surfaces is disclosed.
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公开(公告)号：US4931282A
公开(公告)日：1990-06-05
申请号：US125377
申请日：1987-11-25
申请人： Robert A. Asmus , Daniel C. Duan
发明人： Robert A. Asmus , Daniel C. Duan
CPC分类号： A61L15/58 , A61L24/0015 , A61L24/06 , A61L2300/106 , A61L2300/406 , Y10S526/931
摘要： A pressure-sensitive medical sealant composition comprising (a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups or methallyl groups, which groups are bonded to nitrogen or oxygen atoms; (b) a plasticizer; and (c) an antimicrobial. The medical sealant is highly moisture vapor transmissive and is capable of incorporating large concentrations of iodine. The composition can be used in a variety of medical applications including as a teat plug, a wound or burn dressing, or as a sealant to seal junctions between medical instruments penetrating the skin and the skin. A method of preparing the medical sealant composition in a caulkable form is also disclosed.
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