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47 条记录 (耗时 0.023 秒)

    Substituted di-t-butylphenols and anti-allergic use thereof
    4.
    发明授权
    Substituted di-t-butylphenols and anti-allergic use thereof 失效
    取代的二叔丁基酚及其抗过敏应用

    公开(公告)号：US5049572A

    公开(公告)日：1991-09-17

    申请号：US593342

    申请日：1990-10-01

    申请人： Robert A. Scherrer ,  Mark A. Rustad

    发明人： Robert A. Scherrer ,  Mark A. Rustad

    IPC分类号： A61K31/325 ,  C07C233/64 ,  C07D257/04

    CPC分类号： C07D257/04 ,  C07C255/00

    摘要： Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic substituent are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Pharmacological methods for using such compounds and synthetic intermediates for preparing such compounds are also disclosed.

    摘要翻译： 作为氨基甲酰基或酰氨基取代4位的2,6-二叔丁基酚的新型化合物，该氨基甲酰基或酰氨基被包含酸性取代基的基团取代，可用作白三烯生物合成抑制剂和抗过敏药 代理商 还公开了使用这些化合物和合成中间体制备这些化合物的药理学方法。

    Viscoelastic collagen solution for ophthalmic use and method of preparation
    5.
    发明授权
    Viscoelastic collagen solution for ophthalmic use and method of preparation 失效
    用于眼科用途的粘弹性胶原溶液及其制备方法

    公开(公告)号：US4713446A

    公开(公告)日：1987-12-15

    申请号：US890847

    申请日：1986-08-06

    申请人： Dale P. DeVore ,  Robert A. Scherrer ,  Matthew T. Scholz

    发明人： Dale P. DeVore ,  Robert A. Scherrer ,  Matthew T. Scholz

    IPC分类号： A61F2/00 ,  A61L27/24 ,  C07K14/78 ,  C08H1/06 ,  A61K31/78 ,  A61B17/00

    CPC分类号： C07K14/78 ,  A61L27/24 ,  C08H1/06 ,  A61F2310/00365 ,  Y10S128/08 ,  Y10S514/801 ,  Y10S514/912

    摘要： Chemically-modified collagen is prepared by reacting native collagen with a di or tri-carboxylic acid halide, di or tri-sulfonyl halide, di or tri-anhydride, or di or tri-reactive active ester coupling agent. The reaction is done in a controlled manner so that the degree of cross-linking is limited. Any remaining lysine epsilon amino groups present in the coupled collagen product may be converted to carboxyamido or sulfonamido groups by acid halide, anhydride, sulfonyl halide or active ester amine-modifying agents. The resultant product when dissolved in a physiological buffer provides a viscoelastic solution having therapeutic application in a variety of surgical procedures, particularly in ophthalmic surgery. This viscoelastic solution "melts," i.e., exhibits a dramatic loss of viscosity, when subjected to temperatures of between 32.degree. and 48.degree. C.

    摘要翻译： 通过使天然胶原与二或三羧酸卤化物，二或三磺酰卤，二或三酐或二或三反应活性酯偶联剂反应来制备化学修饰的胶原蛋白。 反应以受控的方式进行，使得交联程度受到限制。 存在于偶联胶原产物中的任何残留的赖氨酸ε氨基可以通过酰卤，酸酐，磺酰卤或活性酯胺改性剂转化为羧酰胺基或亚磺酰氨基。 所得产物当溶解在生理缓冲液中时，提供了一种在各种外科手术中具有治疗应用的粘弹性溶液，特别是在眼科手术中。 这种粘弹性溶液在经受32至48℃的温度时“熔化”，即表现出显着的粘度损失。

    Enamines, pharmaceutical compositions, methods, synthetic processes and intermediates
    7.
    发明授权
    Enamines, pharmaceutical compositions, methods, synthetic processes and intermediates 失效
    烯胺，药物组合物，方法，合成方法和中间体

    公开(公告)号：US4464536A

    公开(公告)日：1984-08-07

    申请号：US439613

    申请日：1982-11-05

    申请人： Robert A. Scherrer ,  George G. I. Moore

    发明人： Robert A. Scherrer ,  George G. I. Moore

    IPC分类号： C07D333/22 ,  A61K31/38 ,  A61K31/381 ,  A61P29/00 ,  C07D333/12 ,  C07D333/20 ,  C07D409/06 ,  C07D521/00 ,  C07D417/06

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D333/12 ,  C07D333/20

    摘要： Antiinflammatory compounds of the following formula are disclosed: ##STR1## wherein R is lower alkyl; R.sup.1 is selected from the group consisting of lower alkyl, benzyl, and N,N-dimethylaminoethyl; or R and R.sup.1 are fused to form an optionally-substituted five- or six-membered heterocyclic ring; and X is hydrogen, methyl or halogen; and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions containing the antiinflammatory compounds and methods of using the antiinflammatory compounds are also described as are a synthetic process and synthetic intermediates for preparing the antiinflammatory compounds.

    摘要翻译： 公开了下式的抗炎化合物：其中R是低级烷基; R1选自低级烷基，苄基和N，N-二甲基氨基乙基; 或R和R 1稠合形成任选取代的五元或六元杂环; X为氢，甲基或卤素; 及其药学上可接受的酸加成盐。 含有抗炎化合物的药物组合物和使用抗炎化合物的方法也被描述为制备抗炎化合物的合成方法和合成中间体。