公开(公告)号：US20060040857A1

公开(公告)日：2006-02-23

申请号：US10540841

申请日：2003-12-29

申请人： Daniel Gomez ,  Daniel Alonso ,  Giselle Ripoll ,  Santiago Giron

发明人： Daniel Gomez ,  Daniel Alonso ,  Giselle Ripoll ,  Santiago Giron

IPC分类号： A61K38/08 ,  A61K38/12 ,  C07K14/575

CPC分类号： C07K7/16 ,  A61K38/00

摘要： 1. Analogs of 1-desamino-8-D-arginyl vasopressin with the following general formula: Mpa-Tyr-Phe-X-Y-Cys-Pro-D-Arg-Gly-NH2 wherein, X is an amino acid of the group consisting of alanine, asparagine, glutamine, isoleucine, leucine and valine; and Y is an amino acid of the group consisting of asparagine, glutamine, isoleucine, leucine and valine. 2. Analogs of 1-desamino-8-D-arginyl vasopressin, as claim 1, with the following general formula: wherein, X is an amino acid of the group consisting of alanine, asparagine, glutamine, isoleucine, leucine and valine; and is an amino acid of the group consisting of asparagine, glutamine, isoleucine, leucine and valine.

摘要翻译： 1. 1-脱氨基-8-D-精氨酰加压素的类似物，具有以下通式：<？in-line-formula description =“In-line formula”end =“lead”？> Mpa-Tyr-Phe-XY- Cys-Pro-D-Arg-Gly-NH 2 <？in-line-formula description =“In-line Formulas”end =“tail”？>其中，X是 由丙氨酸，天冬酰胺，谷氨酰胺，异亮氨酸，亮氨酸和缬氨酸组成的组; Y是由天冬酰胺，谷氨酰胺，异亮氨酸，亮氨酸，缬氨酸组成的组的氨基酸。 2.如权利要求1所述的1-脱氨基-8-D-精氨酰加压素的类似物，其具有以下通式：其中X是丙氨酸，天冬酰胺，谷氨酰胺，异亮氨酸，亮氨酸和缬氨酸组成的组中的氨基酸; 并且是由天冬酰胺，谷氨酰胺，异亮氨酸，亮氨酸和缬氨酸组成的组的氨基酸。