公开(公告)号：US06090982A

公开(公告)日：2000-07-18

申请号：US441235

申请日：1999-11-16

申请人： Daniel John Bayston ,  Jonathan Luke William Griffin ,  Arne Gruman ,  Mario Eugenio Cosimino Polywka ,  Ronald Michael Scott

发明人： Daniel John Bayston ,  Jonathan Luke William Griffin ,  Arne Gruman ,  Mario Eugenio Cosimino Polywka ,  Ronald Michael Scott

IPC分类号： C07C227/18 ,  C07C229/28 ,  C07C251/18 ,  C07C253/00 ,  C07C255/31 ,  C07C229/36 ,  C07C251/06

CPC分类号： C07C255/31 ,  C07C227/18 ,  C07C229/28 ,  C07C251/18 ,  C07C253/00 ,  C07B2200/07 ,  C07C2101/02

摘要： Disclosed is a process for the preparation of cyclopropylglycine by a 5-step process wherein cyclopropanecarboxaldehyde is reacted with an .alpha.-aminoalkylaromatic compound to obtain an imine which is reacted with a cyanide to produce an aminonitrile compound; the aminonitrile compound is hydrolyzed to the corresponding aminocarboxylic acid and finally the arylalkyl residue is removed from the amino group by hydrogenolysis.

公开(公告)号：US06191306B1

公开(公告)日：2001-02-20

申请号：US09365914

申请日：1999-08-03

申请人： Daniel John Bayston ,  Jonathan Luke William Griffin ,  Arne Gruman ,  Mario Eugenio Cosimino Polywka ,  Ronald Michael Scott

发明人： Daniel John Bayston ,  Jonathan Luke William Griffin ,  Arne Gruman ,  Mario Eugenio Cosimino Polywka ,  Ronald Michael Scott

IPC分类号： C07C22718

CPC分类号： C07C255/31 ,  C07B2200/07 ,  C07C227/18 ,  C07C229/28 ,  C07C251/18 ,  C07C253/00 ,  C07C2601/02

摘要： Disclosed is a process for the preparation of cyclopropylglycine by a 5-step process wherein cyclopropanecarboxaldehyde is reacted with an &agr;-aminoalkylaromatic compound to obtain an imine which is reacted with a cyanide to produce an aminonitrile compound; the aminonitrile compound is hydrolyzed to the corresponding aminocarboxylic acid and finally the arylalkyl residue is removed from the amino group by hydrogenolysis.

摘要翻译： 公开了一种通过5步法制备环丙基甘氨酸的方法，其中环丙烷甲醛与α-氨基烷基芳族化合物反应得到亚胺，其与氰化物反应产生氨基腈化合物; 将氨基腈化合物水解成相应的氨基羧酸，最后通过氢解从氨基除去芳烷基残基。

公开(公告)号：US6103929A

公开(公告)日：2000-08-15

申请号：US441526

申请日：1999-11-16

申请人： Daniel John Bayston ,  Jonathan Luke William Griffin ,  Arne Grumann ,  Mario Eugenio Cosimino Polywka ,  Ronald Michael Scott

发明人： Daniel John Bayston ,  Jonathan Luke William Griffin ,  Arne Grumann ,  Mario Eugenio Cosimino Polywka ,  Ronald Michael Scott

IPC分类号： C07C227/18 ,  C07C229/28 ,  C07C251/18 ,  C07C253/00 ,  C07C255/31 ,  C07C229/36 ,  C07C251/06

CPC分类号： C07C255/31 ,  C07C227/18 ,  C07C229/28 ,  C07C251/18 ,  C07C253/00 ,  C07B2200/07 ,  C07C2101/02

摘要： Disclosed is a process for the preparation of cyclopropylglycine by a 5-step process wherein cyclopropanecarboxaldehyde is reacted with an .alpha.-aminoalkylaromatic compound to obtain an imine which is reacted with a cyanide to produce an aminonitrile compound; the aminonitrile compound is hydrolyzed to the corresponding aminocarboxylic acid and finally the arylalkyl residue is removed from the amino group by hydrogenolysis.

摘要翻译： 公开了通过5步法制备环丙基甘氨酸的方法，其中环丙烷甲醛与α-氨基烷基芳族化合物反应得到亚胺，其与氰化物反应产生氨基腈化合物; 将氨基腈化合物水解成相应的氨基羧酸，最后通过氢解从氨基除去芳烷基残基。