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公开(公告)号：US20080153812A1
公开(公告)日：2008-06-26
申请号：US11958720
申请日：2007-12-18
IPC分类号： A61K31/415 , C07D243/08 , C07D413/02 , C07D413/14 , C07D403/02 , C07D403/14 , C07D471/04 , C07D217/00 , C07D401/02 , C07D263/30 , C07D257/04 , C07D249/08 , C07D231/00 , A61K31/5513 , A61K31/5355 , A61K31/497 , A61K31/4439 , A61K31/4709 , A61P35/00 , A61K31/4245 , A61K31/4196 , A61K31/454
CPC分类号： C07D231/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.
摘要翻译： 提供式（I）化合物或其药学上可接受的盐。 还提供了制备式1化合物的方法和式1化合物作为药物和用于治疗癌症的用途。
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![N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-(3,4-dimethylpiperazin-1-yl)benzamide and salts thereof](/abs-image/US/2012/03/06/US08129391B2/abs.jpg.150x150.jpg)
2.发明授权N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-(3,4-dimethylpiperazin-1-yl)benzamide and salts thereof 有权N- [5- [2-（3,5-二甲氧基苯基）乙基] -1H-吡唑-3-基] -4-（3,4-二甲基哌嗪-1-基）苯甲酰胺及其盐公开(公告)号：US08129391B2
公开(公告)日：2012-03-06
申请号：US12771661
申请日：2010-04-30
IPC分类号： A61K31/496 , A61K31/501 , C07D231/38 , C07D403/12
CPC分类号： C07D231/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.
摘要翻译： 提供式（I）化合物或其药学上可接受的盐。 还提供了制备式1化合物的方法和式1化合物作为药物和用于治疗癌症的用途。
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![N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof](/abs-image/US/2010/06/15/US07737149B2/abs.jpg.150x150.jpg)
3.发明授权N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof 有权N- [5- [2-（3,5-二甲氧基苯基）乙基] -2H-吡唑-3-基] -4-（3,5-二甲基哌嗪-1-基）苯甲酰胺及其盐公开(公告)号：US07737149B2
公开(公告)日：2010-06-15
申请号：US11958720
申请日：2007-12-18
IPC分类号： A61K31/4155 , A61K31/496 , C07D231/40 , C07D403/02
CPC分类号： C07D231/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.
摘要翻译： 提供式（I）化合物或其药学上可接受的盐。 还提供了制备式1化合物的方法和式1化合物作为药物和用于治疗癌症的用途。
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![N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-(3,4-dimethylpiperazin-1-yl)benzamide and Salts Thereof](/abs-image/US/2010/10/28/US20100273811A1/abs.jpg.150x150.jpg)
4.发明申请N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-(3,4-dimethylpiperazin-1-yl)benzamide and Salts Thereof 有权N- [5- [2-（3,5-二甲氧基苯基）乙基] -1H-吡唑-3-基] -4-（3,4-二甲基哌嗪-1-基）苯甲酰胺及其盐公开(公告)号：US20100273811A1
公开(公告)日：2010-10-28
申请号：US12771661
申请日：2010-04-30
IPC分类号： A61K31/496 , C07D403/12 , A61P35/00
CPC分类号： C07D231/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.
摘要翻译： 提供式（I）化合物或其药学上可接受的盐。 还提供了制备式1化合物的方法和式1化合物作为药物和用于治疗癌症的用途。
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![N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl]-4-(3,4-dimethylpiperazin-1-yl)benzamide and salts thereof](/abs-image/US/2013/12/10/US08604022B2/abs.jpg.150x150.jpg)
5.发明授权N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl]-4-(3,4-dimethylpiperazin-1-yl)benzamide and salts thereof 有权N- [5- [2-（3,5-二甲氧基苯基）乙基] -1H-吡唑-3-基] -4-（3,4-二甲基哌嗪-1-基）苯甲酰胺及其盐公开(公告)号：US08604022B2
公开(公告)日：2013-12-10
申请号：US13359008
申请日：2012-01-26
IPC分类号： A61K31/415 , A61K31/496 , A61K31/5377 , A61K31/454 , A61K31/4439 , A61K31/551 , C07D231/40 , C07D413/12 , C07D401/12 , C07D401/14 , C07D413/14 , C07D403/12
CPC分类号： C07D231/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.
摘要翻译： 提供式（I）化合物或其药学上可接受的盐。 还提供了制备式1化合物的方法和式1化合物作为药物和用于治疗癌症的用途。
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公开(公告)号：US20090318468A1
公开(公告)日：2009-12-24
申请号：US12487838
申请日：2009-06-19
IPC分类号： A61K31/496 , C07D403/12 , A61P35/00
CPC分类号： C07D231/14
摘要： There is provided novel compounds of formula (Ia) or (Ib): or pharmaceutically acceptable salsts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 提供新的式（Ia）或（Ib）化合物或其药学上可接受的盐，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20080004302A1
公开(公告)日：2008-01-03
申请号：US11769417
申请日：2007-06-27
申请人： Maria-Elena Theoclitou , David Buttar , Kevin Michael Foote , Thorsten Nowak , David Alan Rudge , Andrew Peter Thomas
发明人： Maria-Elena Theoclitou , David Buttar , Kevin Michael Foote , Thorsten Nowak , David Alan Rudge , Andrew Peter Thomas
IPC分类号： A61K31/506 , C07D413/14
CPC分类号： C07D413/14
摘要： There is provided a compound of formula (I): processes for the manufacture thereof, pharmaceutical compositions thereof and uses in therapy.
摘要翻译： 提供式（I）的化合物：其制备方法，其药物组合物和治疗用途。
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![N-[5-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-3-YL]-4-(3,4-DIMETHYLPIPERAZIN-1-YL)BENZAMIDE AND SALTS THEREOF](/abs-image/US/2012/05/24/US20120129844A1/abs.jpg.150x150.jpg)
8.发明申请N-[5-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-3-YL]-4-(3,4-DIMETHYLPIPERAZIN-1-YL)BENZAMIDE AND SALTS THEREOF 有权N- [5- [2-（3,5-二甲氧基苯基）乙基] -1H-吡唑-3-基] -4-（3,4-二甲基哌嗪-1-基）苯甲酰胺及其盐公开(公告)号：US20120129844A1
公开(公告)日：2012-05-24
申请号：US13359008
申请日：2012-01-26
IPC分类号： A61K31/415 , A61K31/496 , C07D231/40 , C07D413/12 , A61K31/5377 , C07D401/12 , A61K31/454 , C07D401/14 , A61K31/4439 , C07D413/14 , C07D409/14 , A61K31/551 , A61P35/00 , A61P35/02 , C07D403/12
CPC分类号： C07D231/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.
摘要翻译： 提供式（I）化合物或其药学上可接受的盐。 还提供了制备式1化合物的方法和式1化合物作为药物和用于治疗癌症的用途。
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公开(公告)号：US20090099210A1
公开(公告)日：2009-04-16
申请号：US12340855
申请日：2008-12-22
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Ann Filla , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译： 本发明涉及具有结构式（I）的新化合物及其药物组合物及其使用方法。 这些新化合物提供癌症的治疗或预防。
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公开(公告)号：US20060041129A1
公开(公告)日：2006-02-23
申请号：US11207128
申请日：2005-08-18
申请人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人： Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号： A61K31/519 , C07D498/02 , C07D491/02
CPC分类号： C07D498/04 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
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