公开(公告)号：US20070277745A1

公开(公告)日：2007-12-06

申请号：US11755497

申请日：2007-05-30

申请人： David Clemmons ,  James Wingate ,  Bryan Jennings ,  William Kerr ,  Thomas Swan ,  Robert Dale

发明人： David Clemmons ,  James Wingate ,  Bryan Jennings ,  William Kerr ,  Thomas Swan ,  Robert Dale

IPC分类号： A01K1/03

CPC分类号： A01K31/06 ,  A01K1/03 ,  A01K31/08

摘要： An animal containment system for use in housing animals, the animal containment system including a floor pan disposed in a first plane, first and second end walls, each said end wall oppositely disposed from each other and including a bottom edge and a top edge, a back wall including a bottom edge and a top edge, two doors, each including a bottom edge and a top edge, oppositely disposed from the back wall arranged to cover the open front portion of said animal containment system, a top panel oppositely disposed from the floor pan, a shelf disposed in between the floor pan and top panel, a wire ladder extending between the floor pan and said shelf, and a wheel base assembly comprising a base panel, four support tubes and at least four removable caster wheels.

摘要翻译： 一种用于住房动物的动物收容系统，所述动物收容系统包括设置在第一平面中的底盘，第一和第二端壁，每个所述端壁彼此相对设置并包括底边缘和顶边缘， 后壁包括底部边缘和顶部边缘，两个门，每个包括底部边缘和顶部边缘，与设置成覆盖所述动物收容系统的敞开前部的后壁相对设置;顶板， 地板盘，设置在地板盘和顶板之间的搁板，在地板盘和所述搁板之间延伸的钢丝绳梯架，以及包括底板，四个支撑管和至少四个可拆卸脚轮的车轮基座组件。

公开(公告)号：US20070224124A1

公开(公告)日：2007-09-27

申请号：US11726028

申请日：2007-03-19

申请人： William Kerr ,  John Ninos

发明人： William Kerr ,  John Ninos

IPC分类号： C12N15/87 ,  A61K49/00 ,  C12N5/00 ,  G01N33/53 ,  C07H21/04

CPC分类号： G01N33/56966 ,  C12N9/16

摘要： SH2 containing inositol 5′-phosphate (SHIP) modulates the activation of immune cells after recruitment to the membrane by Shc and the cytoplasmic tails of receptors. A novel SHIP isoform of approximately 104 kd expressed in primitive stem cell populations (s-SHIP) is described. It was found that s-SHIP is expressed in totipotent embryonic stem cells to the exclusion of the 145-kd SHIP isoform expressed in differentiated hematopoietic cells. s-SHIP is also expressed in primitive hematopoietic stem cells, but not in lineage-committed hematopoietic cells. In embryoic stem cells, s-SHIP partners with the adapter protein Grb2 without tyrosine phosphorylation and is present constitutively at the cell membrane. It is postulated that s-SHIP modulates the activation threshold of primitive stem cell populations.

摘要翻译： 含有肌醇5'-磷酸（SHIP）的SH2通过Shc和受体的胞质尾部募集到膜后调节免疫细胞的活化。 描述了在原始干细胞群体（s-SHIP）中表达的约104kd的新型SHIP同种型。 发现s-SHIP在全能胚胎干细胞中表达，以排除在分化造血细胞中表达的145-kd SHIP同种型。 s-SHIP也在原始造血干细胞中表达，但不在谱系致死的造血细胞中表达。 在胚胎干细胞中，s-SHIP与衔接蛋白Grb2配对，没有酪氨酸磷酸化，并且组成型存在于细胞膜上。 假设s-SHIP调节原始干细胞群体的激活阈值。

公开(公告)号：US20080076731A1

公开(公告)日：2008-03-27

申请号：US11787064

申请日：2007-04-13

申请人： William Kerr

发明人： William Kerr

IPC分类号： A61K48/00

CPC分类号： C12N15/8509 ,  A01K67/0271 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/025 ,  A01K2267/0325 ,  A01K2267/0387 ,  A61K38/00 ,  A61K48/00 ,  C12N9/14 ,  C12N9/16 ,  C12N2800/30 ,  G01N2333/916

摘要： Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of engraftment of an allogeneic bone marrow transplant or solid organ allograft or xenograft. Also disclosed is a transgenic mouse having the genotype SHIP−/− which exhibits enhanced survival following mismatched allogeneic marrow grafts.

摘要翻译： 通过阻断含SH2的肌醇磷酸酶（SHIP）表达或功能，在移植前或移植期间在固体器官移植物或同种异体骨髓移植物中树突状细胞功能的抑制被教导为消除免疫排斥的方法，从而增加植入物 同种异体骨髓移植或实体器官同种异体移植物或异种移植物。 还公开了具有基因型SHIP - / - 的转基因小鼠，其在错配的同种异体骨髓移植物之后表现出增强的存活。

公开(公告)号：US20050271059A1

公开(公告)日：2005-12-08

申请号：US11203317

申请日：2005-08-12

申请人： Valerie Young ,  William Kerr ,  Myron White ,  Venkataraman Prasannan

发明人： Valerie Young ,  William Kerr ,  Myron White ,  Venkataraman Prasannan

IPC分类号： H04J3/00 ,  H04L12/56 ,  H04L12/64 ,  H04L12/66 ,  H04Q11/04 ,  H04L12/28

CPC分类号： H04L12/6418 ,  H04L12/64 ,  H04L2012/5653 ,  H04L2012/6459 ,  H04L2012/6472 ,  H04L2012/6481

摘要： A highly flexible and scalable architecture implements a wide variety of protocol bridging, including ATM SARing (segmentation and reassembly) operations and related functions with single call granularity for network to telecom interface applications such as voice over Internet. A very small packet size minimizes packetization delay so that VOIP can be realized without expensive echo cancellation.

摘要翻译： 高度灵活和可扩展的架构实现了各种协议桥接，包括ATM SARing（分段和重组）操作以及具有单一呼叫粒度的相关功能，用于网络到电信接口应用，如互联网语音。 非常小的分组大小使打包延迟最小化，使得VOIP可以在没有昂贵的回声消除的情况下实现。

公开(公告)号：US20060223749A1

公开(公告)日：2006-10-05

申请号：US10709801

申请日：2004-05-28

申请人： Caroline Desponts ,  Joseph Wahle ,  John Ninos ,  William Kerr

发明人： Caroline Desponts ,  Joseph Wahle ,  John Ninos ,  William Kerr

IPC分类号： A61K48/00

CPC分类号： C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

摘要： The instant invention teaches the inhibition of SHIP expression, or function, for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can be used to temporarily expand and mobilize the hematopoietic stem cell compartment to assist with leukapheresis, to promote hematopoietic recovery after myeloablation treatments, to deplete target stem cell clones (such a leukemic clones and other tumor stem cell types), and to deplete, or damage, the repopulating ability of the endogenous hematopoietic stem cell pool in order to allow transplanted hematopoietic stem cells to better home and engraft and to promote in vivo expansion and mobilization of other organ-specific stem cell populations (e.g., mesenchymal, mammary).

摘要翻译： 本发明教导了对自体干细胞移植物增加功效的SHIP表达或功能的抑制。 在另一个实施方案中，可以使用与SHIP功能的干扰来暂时扩增和动员造血干细胞隔室以协助白细胞分离术，以促进骨髓消融治疗后的造血恢复，以消耗目标干细胞克隆（如白血病克隆和其他肿瘤干细胞 类型），并且消耗或损害内源性造血干细胞池的再生能力，以便允许移植的造血干细胞更好地回家和移植并促进其他器官特异性干细胞群的体内扩增和动员（ 例如间充质，乳腺）。

公开(公告)号：US4063741A

公开(公告)日：1977-12-20

申请号：US622515

申请日：1975-10-15

申请人： William Kerr

发明人： William Kerr

IPC分类号： F16J15/36

CPC分类号： F16J15/36

摘要： In a fluid face seal assembly comprising an elastomeric annular seal for engaging in a recess of a stationary housing or the like component, an axially directed extension on a radially inner limb of the annular seal, an annular face seal carried by said extension and spring means acting between said face seal and said annular seal to maintain a resilient relationship between the two, the invention provides a step constituting a carrier member at the free end of the extension and a thickened free end on the step which retains the face seal in abutment against the shoulder between the step and the remainder of the extension, and a retainer acting to compress the thickened end of the step between itself and a radially adjacent part of the face seal thereby mechanically to lock said face seal onto said carrier member.

摘要翻译： 在流体面密封组件中，包括用于接合固定壳体或类似部件的凹部的弹性体环形密封件，在环形密封件的径向内侧上的轴向延伸部，由所述延伸部和弹簧装置 作用在所述面密封件和所述环形密封件之间以保持两者之间的弹性关系，本发明提供了在延伸部的自由端处构成承载构件的台阶上的台阶上的增厚的自由端，其保持面密封件邻接 踏板和延伸件的其余部分之间的肩部，以及用于将台阶之间的增厚端压缩在其与面密封件的径向相邻部分之间的保持器，从而机械地将所述面密封件锁定在所述托架构件上。