公开(公告)号：US20130059902A1

公开(公告)日：2013-03-07

申请号：US13577648

申请日：2011-02-08

申请人： David Corey ,  C. Frank Bennett ,  Eric E. Swayze ,  Keith Gagnon

发明人： David Corey ,  C. Frank Bennett ,  Eric E. Swayze ,  Keith Gagnon

IPC分类号： C07H21/02 ,  A61P25/00 ,  A61P21/00 ,  C12N5/07 ,  A61K31/712

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/344 ,  C12N2310/346

摘要： The present invention is drawn to chemically-modified oligomers that are complementary to, and capable of hybridizing within the repeat region of CAG, CUG, or CCUG nucleotide repeat-containing RNAs (NRRs).

摘要翻译： 本发明涉及与CAG，CUG或含有CCUG核苷酸重复的RNA（NRR）的重复区域互补且能够杂交的化学修饰的寡聚体。

公开(公告)号：US09976138B2

公开(公告)日：2018-05-22

申请号：US14342176

申请日：2012-08-29

申请人： Thazha P. Prakash ,  Eric E. Swayze ,  David Corey ,  Dongbo Yu

发明人： Thazha P. Prakash ,  Eric E. Swayze ,  David Corey ,  Dongbo Yu

IPC分类号： C07H21/04 ,  C12N15/113 ,  A61K31/7088

CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/323 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/343 ,  C12N2310/344 ,  C12N2310/351 ,  C12N2310/3521 ,  C12N2310/3533 ,  C12N2310/533 ,  C12N2320/34

摘要： Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules.

公开(公告)号：US20140316121A1

公开(公告)日：2014-10-23

申请号：US14342176

申请日：2012-08-29

申请人： Thazha P. Prakash ,  Eric E. Swayze ,  David Corey ,  Dongbo Yu

发明人： Thazha P. Prakash ,  Eric E. Swayze ,  David Corey ,  Dongbo Yu

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/323 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/343 ,  C12N2310/344 ,  C12N2310/351 ,  C12N2310/3521 ,  C12N2310/3533 ,  C12N2310/533 ,  C12N2320/34

摘要： Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules.

摘要翻译： 描述了可用于治疗和调查与扩大的含有重复RNA分子相关的疾病和病症的化合物和方法。

公开(公告)号：US20080156885A1

公开(公告)日：2008-07-03

申请号：US11966018

申请日：2007-12-28

申请人： Steven Landau ,  David Corey

发明人： Steven Landau ,  David Corey

IPC分类号： G06K19/06

CPC分类号： G06K19/077 ,  G06K19/0702

摘要： An electronic card comprises a thin, flexible substrate having electrical circuitry embedded therein. An activation device is disposed in the substrate and is configured to complete a circuit in response to a stimulus, such as light or sound. An output device is disposed in the substrate and is configured to produce an output, such as music or vibration, wherein the output device is activated upon the completion of the circuit by the activation device. A cavity is formed in an outer surface of the substrate and has electrical contacts at an inner portion thereof in electrical communication with the electrical circuitry. The cavity further comprises retaining means for replaceably retaining a battery in the cavity to enable the battery to provide power to the electrical circuitry, the activation device, and the output device. The retaining means allows a battery to be removed from the cavity and replaced with another battery.

摘要翻译： 电子卡包括一个薄而柔性的基片，其中嵌有电路。 激活装置设置在基板中并且被配置为响应于诸如光或声的刺激来完成电路。 输出装置设置在基板中并且被配置为产生诸如音乐或振动的输出，其中输出装置在激活装置完成电路时被激活。 空腔形成在基板的外表面中，并且在其内部具有与电路电连通的电触点。 空腔还包括用于可替换地将电池保持在空腔中的保持装置，以使电池能够向电路，激活装置和输出装置提供电力。 保持装置允许将电池从腔中移除并用另一个电池替代。

公开(公告)号：US20070111963A1

公开(公告)日：2007-05-17

申请号：US11599566

申请日：2006-11-13

申请人： David Corey ,  Bethany Janowski ,  David Shames ,  John Minna

发明人： David Corey ,  Bethany Janowski ,  David Shames ,  John Minna

IPC分类号： A61K48/00

CPC分类号： C12N15/63 ,  A61K48/005 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N15/1138 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/331 ,  C12N2320/50 ,  C12N2310/3521

摘要： Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.

摘要翻译： 通过使细胞与基因的靶启动子内的区域互补的12-28个碱基的多核苷酸寡聚体接触，在哺乳动物细胞中选择性地增加基因的靶转录物的合成，由此寡聚体选择性地增加靶的合成 成绩单

公开(公告)号：US20060205635A1

公开(公告)日：2006-09-14

申请号：US11376483

申请日：2006-03-14

申请人： David Corey ,  Bethany Janowski

发明人： David Corey ,  Bethany Janowski

IPC分类号： A61K48/00 ,  C07K14/47 ,  A61K31/675 ,  C07F9/6512

CPC分类号： C12N15/1138 ,  C12N15/113 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/3181 ,  C12N2310/3233 ,  C12N2320/30

摘要： Transcription of a gene in a mammalian cell is methylase-independently inhibited by contacting the cell with a nucleic acid oligomer of 12-28 bases complementary for a partially single-stranded target genomic sequence of the gene.

公开(公告)号：US07967214B2

公开(公告)日：2011-06-28

申请号：US11966018

申请日：2007-12-28

申请人： Steven Landau ,  David Corey

发明人： Steven Landau ,  David Corey

IPC分类号： G06K19/06

CPC分类号： G06K19/077 ,  G06K19/0702

摘要： An electronic card comprises a thin, flexible substrate having electrical circuitry embedded therein. An activation device is disposed in the substrate and is configured to complete a circuit in response to a stimulus, such as light or sound. An output device is disposed in the substrate and is configured to produce an output, such as music or vibration, wherein the output device is activated upon the completion of the circuit by the activation device. A cavity is formed in an outer surface of the substrate and has electrical contacts at an inner portion thereof in electrical communication with the electrical circuitry. The cavity further comprises retaining means for replaceably retaining a battery in the cavity to enable the battery to provide power to the electrical circuitry, the activation device, and the output device. The retaining means allows a battery to be removed from the cavity and replaced with another battery.

摘要翻译： 电子卡包括一个薄而柔性的基片，其中嵌有电路。 激活装置设置在基板中并且被配置为响应于诸如光或声的刺激来完成电路。 输出装置设置在基板中并且被配置为产生诸如音乐或振动的输出，其中输出装置在激活装置完成电路时被激活。 空腔形成在基板的外表面中，并且在其内部具有与电路电连通的电触点。 空腔还包括用于可替换地将电池保持在空腔中的保持装置，以使电池能够向电路，激活装置和输出装置提供电力。 保持装置允许将电池从腔中移除并用另一个电池替代。