公开(公告)号：US11065206B2

公开(公告)日：2021-07-20

申请号：US14129747

申请日：2012-06-29

Applicant: David Craig Wright

Inventor： David Craig Wright

IPC: A61K9/48 ,  A61K31/355 ,  A61K45/06 ,  A61K9/50 ,  A61K9/00 ,  A61K47/14 ,  A61K9/06 ,  A61K31/592 ,  A61K31/593

Abstract: The present invention relates to topical formulations that include lipid microcapsules formed from tocopherol, tocotrienol, or mixtures thereof; a stabilizer/surfactant component; and an aqueous component. The lipid microcapsules may be formed without the use of steroids, preservatives, initiators and/or oils. The topical formulations are capable of delivering transdermal active agent(s) such as vitamin D through the skin and into the bloodstream without the use of skin penetration enhancers. In certain embodiments, the topical formulations also able to deliver topical active agent(s) such as sun-protecting agents to the surface of the skin where they remain, while simultaneously delivering the transdermal active agent(s) through the skin and into the bloodstream.

公开(公告)号：US20140348910A1

公开(公告)日：2014-11-27

申请号：US14129747

申请日：2012-06-29

Applicant: David Craig Wright

Inventor： David Craig Wright

IPC: A61K9/48 ,  A61K31/592 ,  A61K31/593 ,  A61K31/355

CPC classification number: A61K9/4816 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/5015 ,  A61K31/355 ,  A61K31/592 ,  A61K31/593 ,  A61K45/06 ,  A61K47/14 ,  A61K2300/00

Abstract: The present invention relates to topical formulations that include lipid microcapsules formed from tocopherol, tocotrienol, or mixtures thereof; a stabilizer/surfactant component; and an aqueous component. The lipid microcapsules may be formed without the use of steroids, preservatives, initiators and/or oils. The topical formulations are capable of delivering transdermal active agent(s) such as vitamin D through the skin and into the bloodstream without the use of skin penetration enhancers. In certain embodiments, the topical formulations also able to deliver topical active agent(s) such as sun-protecting agents to the surface of the skin where they remain, while simultaneously delivering the transdermal active agent(s) through the skin and into the bloodstream.

Abstract translation: 本发明涉及包括由生育酚，生育三烯酚或其混合物形成的脂质微胶囊的局部制剂; 稳定剂/表面活性剂组分; 和水性成分。 可以在不使用类固醇，防腐剂，引发剂和/或油的情况下形成脂质微胶囊。 局部制剂能够在不使用皮肤渗透增强剂的情况下通过皮肤递送透皮活性剂（例如维生素D）并进入血流。 在某些实施方案中，局部制剂还能够将表面活性剂（例如防晒剂）递送至皮肤表面保留，同时将透皮活性剂递送穿过皮肤并进入血流 。