公开(公告)号：US08048439B2

公开(公告)日：2011-11-01

申请号：US11128265

申请日：2005-05-13

申请人： David Dakin Iorwerth Wright ,  Anthony David Harman ,  Nikki Robinson ,  Garry Hodges ,  Adil Kadar ,  Geoffrey D. Moggridge ,  Hugh Van Liew ,  William John Jenkins

发明人： David Dakin Iorwerth Wright ,  Anthony David Harman ,  Nikki Robinson ,  Garry Hodges ,  Adil Kadar ,  Geoffrey D. Moggridge ,  Hugh Van Liew ,  William John Jenkins

IPC分类号： A61K9/08

CPC分类号： A61K9/122

摘要： A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurized canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimizing the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.

摘要翻译： 用于治疗静脉曲张的治疗性泡沫包括用诸如二氧化碳，氧气或其混合物的生理气体发泡的硬化溶液。 泡沫的氮含量小于0.8％。 它可以使用包含微米尺寸的精细网格的加压罐系统来产生，气体和硬化液通过该微孔尺寸通过以制造泡沫。 或者，泡沫可以通过气体和溶液在两个注射器之间通过细网而产生。 描述了用于最小化基于罐或注射器的产品中氮的量的技术。 还公开了一种使用基于注射器的装置同时产生和递送泡沫的技术。

公开(公告)号：US20080274060A1

公开(公告)日：2008-11-06

申请号：US11914190

申请日：2006-05-12

申请人： David Dakin Iorwerth Wright ,  Anthony David Harman ,  Nikki Robinson ,  Garry Hodges ,  Adil Kadar ,  Hugh Van Liew ,  Geoffrey D. Moggridge ,  William John Jenkins

发明人： David Dakin Iorwerth Wright ,  Anthony David Harman ,  Nikki Robinson ,  Garry Hodges ,  Adil Kadar ,  Hugh Van Liew ,  Geoffrey D. Moggridge ,  William John Jenkins

IPC分类号： A61K9/12 ,  A61P7/00

CPC分类号： A61K9/0019 ,  A61K9/122 ,  A61K9/124 ,  A61K31/77

摘要： A foam is described for injection treatment of varicose veins. The foam comprises a sclerosant liquid, e.g. polidocanol solution, and a gas. The gas comprises xenon, optionally together with at least one other physiologically acceptable gas which is readily absorbed in the body or blood of a patient. The gas comprises only a minimal amount of gaseous nitrogen, between 0.0001% and 0.8%.

摘要翻译： 描述了用于静脉曲张的注射治疗的泡沫。 泡沫包括硬化液体，例如， 波多契醇溶液和气体。 气体包括氙，任选地与至少一种容易被吸收在患者体内或血液中的生理上可接受的气体组合。 气体仅包含最小量的气态氮，介于0.0001％和0.8％之间。

公开(公告)号：US20090124704A1

公开(公告)日：2009-05-14

申请号：US11914192

申请日：2006-05-12

申请人： William John Jenkins

发明人： William John Jenkins

IPC分类号： A61K31/08 ,  A61K47/04 ,  A61P9/14

CPC分类号： A61K9/0019 ,  A61K9/122 ,  A61K31/08

摘要： A foam for the treatment of varicose veins is disclosed, comprising a sclersosant solution, e.g. polidocanol, foamed with a gas mixture which includes greater than 41 % of a lipid soluble gas such as xenon. The aim is to provide a foam which may be injected into a varicose vein in large quantities because the gas component is dissipated quickly after the foam has acted on the varicose vein.

摘要翻译： 公开了一种用于治疗静脉曲张的泡沫，其包括诸如鞘内注射溶液等。 用包含大于41％的脂质可溶性气体如氙的气体混合物发泡的聚多糖醇。 目的是提供可以大量注射到静脉曲张中的泡沫，因为气泡成分在泡沫作用于静脉曲张后迅速消散。

公开(公告)号：US08703827B2

公开(公告)日：2014-04-22

申请号：US11914192

申请日：2006-05-12

申请人： William John Jenkins

发明人： William John Jenkins

IPC分类号： A01N31/14

CPC分类号： A61K9/0019 ,  A61K9/122 ,  A61K31/08

摘要： A foam for the treatment of varicose veins is disclosed, comprising a sclersosant solution, e.g. polidocanol, foamed with a gas mixture which includes greater than 41% of a lipid soluble gas such as xenon. The aim is to provide a foam which may be injected into a varicose vein in large quantities because the gas component is dissipated quickly after the foam has acted on the varicose vein.

摘要翻译： 公开了一种用于治疗静脉曲张的泡沫，其包括诸如鞘内注射溶液等。 用包含大于41％的脂质可溶性气体如氙的气体混合物发泡的聚多糖醇。 目的是提供可以大量注射到静脉曲张中的泡沫，因为气泡成分在泡沫作用于静脉曲张后迅速消散。