公开(公告)号：US07109168B1

公开(公告)日：2006-09-19

申请号：US10048307

申请日：2000-06-16

Applicant: David E. Wright ,  D. Elliott Parks

Inventor： David E. Wright ,  D. Elliott Parks

IPC: A61K38/16 ,  C07K7/08 ,  C07K14/00 ,  C07K1/00

CPC classification number: A61K38/10 ,  A61K38/16 ,  C07K5/0212 ,  C07K7/02 ,  C07K14/5415

Abstract: Retro-inverso peptides derived from leukemia inhibitory factor (LIF) having between 18 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native LIF and also have neurotrophic activity. Because of the D-amino acid linkage in the peptides, they are less susceptible to proteolytic degradation in vivo.

Abstract translation: 衍生自具有18至约40个氨基酸的白血病抑制因子（LIF）的逆转肽，并且包括SEQ ID NO：1所示的序列。这些肽具有与天然LIF相同的活性并且还具有神经营养活性。 由于肽中的D-氨基酸连接，它们在体内不易于蛋白水解降解。

公开(公告)号：US06715217B1

公开(公告)日：2004-04-06

申请号：US10283952

申请日：2002-10-30

Applicant: David E. Wright ,  Dwayne D. Wright

Inventor： David E. Wright ,  Dwayne D. Wright

IPC: F26B304

CPC classification number: F26B21/004 ,  F26B9/006 ,  F26B21/001

Abstract: A microfilm drying device and method are presented for salvaging and drying microfilm which has become wet due to excessive moisture resulting from high water, floods and the like. The device includes a needle assembly which is slidably affixed within a frame to direct air into the internal compartments of a flexible jacket containing microfilm strips. In another embodiment, a hand held drying device allows air to pass through a series of needles to dry the interior of the flexible jackets.

Abstract translation: 提供一种微缩胶片干燥装置和方法，用于回收和干燥由于高水，洪水等导致的过多水分而变湿的微缩胶卷。 该装置包括可滑动地固定在框架内以将空气引导到包含微缩胶条的柔性护套的内部隔间中的针组件。 在另一个实施例中，手持式干燥装置允许空气通过一系列针以干燥柔性护套的内部。

公开(公告)号：US06431996B1

公开(公告)日：2002-08-13

申请号：US09613148

申请日：2000-07-11

Applicant: David E. Wright ,  Mustapha Hayouna

Inventor： David E. Wright ,  Mustapha Hayouna

IPC: A63B5300

CPC classification number: A63B53/00 ,  A63B53/12 ,  A63B60/00 ,  A63B60/42 ,  A63B60/54 ,  A63B2060/002 ,  A63B2209/14

Abstract: A golf club having suppressed vibration modes is disclosed. The club comprises a shaft, a golf club head, a grip and a plurality of discrete shaft stiffeners. The shaft stiffeners are strategically located along the shaft so as to shift the nodes of at least the second and third flexural vibration modes of the club shaft such that a node of each of the second and third flexural vibration modes occurs both at the club face and within the region underlying the golf club grip. Preferably, the stiffeners are made of a shape memory alloy that can be shrunk onto the outside surface of the shaft, then expanded to permit the position of the stiffeners to be adjusted to suit the boundary conditions imposed by the human user.

Abstract translation: 公开了一种具有抑制振动模式的高尔夫球杆。 该球杆包括轴，高尔夫球杆头，手柄和多个分立的轴加强件。 轴加强件在轴上具有战略位置，以便使球杆杆杆的至少第二和第三弯曲振动模式的节点移动，使得第二和第三弯曲振动模式中的每一个的节点都在球杆表面和 在高尔夫球杆握把下面的区域内。 优选地，加强件由可以收缩到轴的外表面上的形状记忆合金制成，然后膨胀以允许调整加强件的位置以适应人类使用者施加的边界条件。

公开(公告)号：USD386551S

公开(公告)日：1997-11-18

申请号：US62687

申请日：1996-11-21

Applicant: John A. Solheim ,  David E. Wright ,  Daniel J. Kubica

Designer： John A. Solheim ,  David E. Wright ,  Daniel J. Kubica

公开(公告)号：US07273420B2

公开(公告)日：2007-09-25

申请号：US11019816

申请日：2004-12-21

Applicant: David E. Wright

Inventor： David E. Wright

IPC: A63B53/04

CPC classification number: A63B53/0487 ,  A63B60/54 ,  A63B2053/0416 ,  A63B2053/0425 ,  A63B2053/0441 ,  A63B2053/0462 ,  A63B2053/0491

Abstract: A golf club head has a cavity for receiving a face insert. A first face insert, which is disposed in the cavity, has a front surface that is contoured. A second face insert composed of multiple rod elements is disposed in the cavity on top of the first face insert so that the rod elements are supported by the contoured front surface of the first face insert. Because the first face insert supporting the rod elements is contoured, the individual rod elements are of different lengths and, therefore, exhibit different dynamic responses when striking a golf ball, even when the rod elements are made of the same material.

Abstract translation: 高尔夫球杆头具有用于接收面部插入物的空腔。 设置在空腔中的第一面插入件具有轮廓的前表面。 由多个杆元件组成的第二面插入件设置在第一面插入物的顶部上的空腔中，使得杆元件由第一面插入物的轮廓前表面支撑。 因为支撑杆元件的第一面插件是轮廓形状的，所以各个杆元件具有不同的长度，并且因此即使当杆元件由相同的材料制成时也会在打高尔夫球时表现出不同的动态响应。

公开(公告)号：US07086961B2

公开(公告)日：2006-08-08

申请号：US10151346

申请日：2002-05-20

Applicant: David E. Wright ,  Eric V. Cole

Inventor： David E. Wright ,  Eric V. Cole

IPC: A63B53/04

CPC classification number: A63B53/0487 ,  A63B53/047 ,  A63B60/54 ,  A63B2053/0416 ,  A63B2053/0425 ,  A63B2053/0491 ,  A63B2060/002 ,  A63B2209/00

Abstract: A selectable insert for a golf club head (e.g., for a golf putter) is configured to produce a predetermined frequency response through the use of, for example, a damped single-degree-of-freedom (SDOF) system. A set of such inserts are provided, and one or more inserts from that set is selected in accordance with the response of an individual, for example, an individual's subjective response to the sound of the insert and/or an individual's biomechanical response to the “feel” or discomfort produced by vibrations propagating through the golf club to the individual. In this way, a customized insert may be selected in accordance with, for example: whether and to what extent the individual finds the frequency response of the inset pleasing to the ear; the extent to which the insert produces unpleasant vibrations in the hands, wrists, arms, and other parts of the individual's body; whether the weighting of the club head is suitable; whether the club head is susceptible to unwanted twisting during impact; and/or whether the overall “feel” of the club is subjectively acceptable.

公开(公告)号：USD379393S

公开(公告)日：1997-05-20

申请号：US47390

申请日：1995-12-01

Applicant: Daniel J. Kubica ,  John A. Solheim ,  David E. Wright

Designer： Daniel J. Kubica ,  John A. Solheim ,  David E. Wright

公开(公告)号：US5595552A

公开(公告)日：1997-01-21

申请号：US573525

申请日：1995-12-15

Applicant: David E. Wright ,  John A. Solheim ,  Daniel J. Kubica

Inventor： David E. Wright ,  John A. Solheim ,  Daniel J. Kubica

IPC: A63B53/04 ,  A63B59/00

CPC classification number: A63B53/04 ,  A63B53/047 ,  A63B2053/0441 ,  A63B2053/045 ,  A63B2053/0454 ,  A63B2053/0458 ,  A63B53/0466 ,  A63B53/0487 ,  A63B60/54

Abstract: A golf club head includes a heel end, a toe end, a front face arranged to impact a golf ball, and a back face disposed rearwardly of the front face. A perimeter weighting element protrudes rearwardly away from the front face and defines a cavity in the back face. The perimeter weighting element includes a top rail and a sole. A plurality of ribs are disposed in the cavity for eliminating undesirable vibrations in the golf club head when the front face impacts a golf ball and for attenuating other vibrations in the golf club head. Each of the ribs extends generally radially relative to the cavity from an inner end to an outer end that merges with the perimeter weighting element. An elliptically shaped geometric region is formed in a bottom surface of the cavity for assisting the plurality of ribs in eliminating the undesirable vibrations and in attenuating the other vibrations.

Abstract translation: 高尔夫球杆头包括脚跟端，脚趾端，布置成冲击高尔夫球的前表面，以及设置在前表面后方的后表面。 周边加权元件从前表面向后突出并且在背面中限定空腔。 周边加权元件包括顶部轨道和鞋底。 多个肋设置在空腔中，用于消除高尔夫球杆头中的不期望的振动，当前表面撞击高尔夫球并衰减高尔夫球杆头中的其它振动时。 每个肋从内周大致径向延伸，从内端到与端部加重元件合并的外端。 椭圆形几何区域形成在空腔的底表面中，用于辅助多个肋来消除不期望的振动并且衰减其它振动。

公开(公告)号：US4742156A

公开(公告)日：1988-05-03

申请号：US902351

申请日：1986-08-29

Applicant: David E. Wright

Inventor： David E. Wright

IPC: A61K38/00 ,  C07K7/22 ,  A61K37/02 ,  C07C103/52

CPC classification number: C07K7/22 ,  A61K38/00

Abstract: Four decapeptides found to be analgesics and have antagonist activity to Neurokinin B which is also known as Neuromedin K. The decapeptide are of the following formula (I):A.sup.1 -D-Pro.sup.2 His.sup.3 -D.sup.4 Phe.sup.5 D-Trp.sup.6 Val.sup.7 -D-Trp.sup.8 -Leu.sup.9 -Nle.sup.10 -NH.sub.2 (I)wherein A.sup.1 and D.sup.4 are Asp or D-Asp amino acids. Also described is an opthalmic solution to treat pain or inflammation and an HPLC separation method using piperidine.

Abstract translation: 发现是止痛剂的四个十肽，并且对神经激肽B也有拮抗剂活性，其也称为神经调节素K.该十肽具有下式（I）：A1-D-Pro2His3-D4Phe5D-Trp6Val7-D-Trp8-Leu9-Nle10- NH2（I）其中A1和D4是Asp或D-Asp氨基酸。 还描述了治疗疼痛或炎症的眼药水和使用哌啶的HPLC分离方法。

公开(公告)号：US07754688B2

公开(公告)日：2010-07-13

申请号：US11544507

申请日：2006-10-05

Applicant: David E. Wright ,  D. Elliott Parks

Inventor： David E. Wright ,  D. Elliott Parks

IPC: A61K38/10 ,  A61K38/00 ,  C07K2/00 ,  C07K7/08 ,  A61K38/02

CPC classification number: A61K38/10 ,  A61K38/204 ,  C07K5/0212 ,  C07K7/02

Abstract: This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO: 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage.

Abstract translation: 本发明提供了使用衍生自具有15至约40个氨基酸的白细胞介素-6（IL-6）的逆转换肽的治疗方法，并且包括相对于SEQ ID NO：1反向逆转的序列，即其中 所述肽包含序列D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D -Ala-D-Leu-D-Ala-D-Glu。 本发明的肽具有与天然IL-6相同的活性并具有神经营养活性。 由于它们的D-氨基酸连接，本发明的肽也不太容易在体内蛋白水解降解。