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1.发明申请J591 MINIBODIES AND CYS-DIABODIES FOR TARGETING HUMAN PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) AND METHODS FOR THEIR USE 有权J591针对人类前列腺特异性膜抗原（PSMA）及其使用方法的小型和半胱氨酸公开(公告)号：US20110268656A1
公开(公告)日：2011-11-03
申请号：US12959340
申请日：2010-12-02
申请人： David Ho , Tove Olafsen , Arye Lipman
发明人： David Ho , Tove Olafsen , Arye Lipman
CPC分类号： C07K16/3069 , A61K51/1072 , C07K2317/24 , C07K2317/526 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/77 , C07K2317/90
摘要： In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided.
摘要翻译： 在一个实施方案中，提供了结合PSMA的微单体。 小体抗体单体由包含N末端至C末端的核苷酸序列编码，可以结合PSMA，人造铰链序列和人IgG CH3序列的scFv序列。 在另一个实施方案中，提供了结合PSMA的CysDB单体。 CysDB单体可以由包含从N末端到C末端的可以结合PSMA和半胱氨酸尾部的scFv序列的核苷酸序列编码。 在其它实施方案中，提供了用于诊断或治疗与受试者中的PSMA表达相关的癌症的方法。
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2.发明授权J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use 有权用于靶向人前列腺特异性膜抗原（PSMA）的J591微型抗体和Cys-双抗体及其使用方法公开(公告)号：US08772459B2
公开(公告)日：2014-07-08
申请号：US12959340
申请日：2010-12-02
申请人： David Ho , Tove Olafsen , Arye Lipman
发明人： David Ho , Tove Olafsen , Arye Lipman
IPC分类号： C07K16/30
CPC分类号： C07K16/3069 , A61K51/1072 , C07K2317/24 , C07K2317/526 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/77 , C07K2317/90
摘要： In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided.
摘要翻译： 在一个实施方案中，提供了结合PSMA的微单体。 小体抗体单体由包含N末端至C末端的核苷酸序列编码，可以结合PSMA，人造铰链序列和人IgG CH3序列的scFv序列。 在另一个实施方案中，提供了结合PSMA的CysDB单体。 CysDB单体可以由包含从N末端到C末端的可以结合PSMA和半胱氨酸尾部的scFv序列的核苷酸序列编码。 在其它实施方案中，提供了用于诊断或治疗与受试者中的PSMA表达相关的癌症的方法。
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