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    J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use
    6.
    发明授权
    J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use 有权
    用于靶向人前列腺特异性膜抗原（PSMA）的J591微型抗体和Cys-双抗体及其使用方法

    公开(公告)号：US08772459B2

    公开(公告)日：2014-07-08

    申请号：US12959340

    申请日：2010-12-02

    申请人： David Ho ,  Tove Olafsen ,  Arye Lipman

    发明人： David Ho ,  Tove Olafsen ,  Arye Lipman

    IPC分类号： C07K16/30

    CPC分类号： C07K16/3069 ,  A61K51/1072 ,  C07K2317/24 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/77 ,  C07K2317/90

    摘要： In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided.

    摘要翻译： 在一个实施方案中，提供了结合PSMA的微单体。 小体抗体单体由包含N末端至C末端的核苷酸序列编码，可以结合PSMA，人造铰链序列和人IgG CH3序列的scFv序列。 在另一个实施方案中，提供了结合PSMA的CysDB单体。 CysDB单体可以由包含从N末端到C末端的可以结合PSMA和半胱氨酸尾部的scFv序列的核苷酸序列编码。 在其它实施方案中，提供了用于诊断或治疗与受试者中的PSMA表达相关的癌症的方法。

    COVALENT DISULFIDE-LINKED DIABODIES AND USES THEREOF
    8.
    发明申请
    COVALENT DISULFIDE-LINKED DIABODIES AND USES THEREOF 有权
    共有的二极体连接的二极体及其用途

    公开(公告)号：US20120283418A1

    公开(公告)日：2012-11-08

    申请号：US13554306

    申请日：2012-07-20

    申请人： Anna M. Wu ,  John E. Shively ,  Andrew A. Raubitschek ,  Mark A. Sherman ,  Tove Olafsen

    发明人： Anna M. Wu ,  John E. Shively ,  Andrew A. Raubitschek ,  Mark A. Sherman ,  Tove Olafsen

    IPC分类号： C07K16/00

    CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/3007 ,  C07K16/46 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/90 ,  C07K2319/00

    摘要： The present invention provides recombinant antibody fragments which include a variable domain which has been modified by the addition of a tail sequence to its C-terminal end. The tail sequence comprises a terminal cysteine residue and an amino acid spacer and does not substantially affect the fragment's target-binding affinity. The present invention also provides pharmaceutical compositions comprising the described antibody fragments and a pharmaceutically acceptable carrier and methods of delivering an agent to cells of interest in a subject using the fragments as delivery vehicles. The invention further provides compositions comprising the described antibody fragments for the in vitro detection and measurement of target molecules which bind to the fragments and method of determining the presence or amount of such targets in a biological sample by contacting the sample with such compositions.

    摘要翻译： 本发明提供重组抗体片段，其包括通过向其C末端添加尾序列而被修饰的可变结构域。 尾序列包含末端半胱氨酸残基和氨基酸间隔基，并且基本上不影响片段的靶结合亲和力。 本发明还提供包含所述抗体片段和药学上可接受的载体的药物组合物，以及使用片段作为递送载体将试剂递送至受试者感兴趣的细胞的方法。 本发明还提供了包含所述抗体片段的组合物，用于体外检测和测量结合片段的靶分子，以及通过使样品与这些组合物接触来确定生物样品中这些靶的存在或量的方法。