公开(公告)号：US5169780A

公开(公告)日：1992-12-08

申请号：US549830

申请日：1990-07-09

申请人： David I. Stirling ,  Andrew L. Zeitlin ,  George W. Matcham ,  James D. Rozzell, Jr.

发明人： David I. Stirling ,  Andrew L. Zeitlin ,  George W. Matcham ,  James D. Rozzell, Jr.

IPC分类号： C12N9/10 ,  C12P7/26 ,  C12P41/00

CPC分类号： C12N9/1096 ,  C12P41/006 ,  C12P7/26

摘要： Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process can be used to stereoselectively sythesize one chiral form from ketones substantially to the exclusion of the other. An aqueous solution of chiral amines after being brought into contact with an omega-amino acid transaminase and an amino acceptor is treated with a water-immiscible organic solvent, the aqueous and organic phases are separated, and the aqueous phase can be recirculated for further contact with the transaminase.

摘要翻译： 其中氨基在手性取代的仲碳原子上的胺可通过ω-氨基酸转氨酶的作用而被对映体富集，该氨基酸转氨酶具有优先将两种手性形式之一转化为酮的性质。 该方法可用于立体选择性地将酮的一种手性形式基本上与另一种不同。 与ω-氨基酸转氨酶和氨基受体接触后手性胺的水溶液用水不混溶的有机溶剂处理，水相和有机相被分离，水相可再循环以进一步接触 与转氨酶。