公开(公告)号：US07193058B2

公开(公告)日：2007-03-20

申请号：US10875869

申请日：2004-06-23

申请人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

发明人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

IPC分类号： C07K16/00 ,  C07K16/18 ,  C12N5/12 ,  C12P21/08

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

摘要： The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-γ production, NK cell proliferation, and CTL activity.

摘要翻译： 本发明涉及纯化和分离的新型ULBP多肽，编码此类多肽的核酸，生产此类多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽以及上述用途。 ULBP多肽可以在人B细胞淋巴瘤的表面上发现。 提供分离或纯化形式的ULBP多肽的哺乳动物形式。 此外，提供了编码ULBP多肽的分离的核酸和包含编码ULBP多肽的cDNA的表达载体。 ULBP多肽可以被分离或合成并用于制备针对多肽的抗体，特别是单克隆抗体。 抗体又可用于检测人细胞样品中ULBP多肽的存在，这可与患者中恶性病症的存在相关。 ULBP多肽刺激IFN-γ产生，NK细胞增殖和CTL活性。

公开(公告)号：US06774224B2

公开(公告)日：2004-08-10

申请号：US10212507

申请日：2002-08-05

申请人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

发明人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

IPC分类号： C07H2100

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

摘要： The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-&ggr; production, NK cell proliferation, and CTL activity.

摘要翻译： 本发明涉及纯化和分离的新型ULBP多肽，编码此类多肽的核酸，生产此类多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽以及上述用途。 ULBP多肽可以在人B细胞淋巴瘤的表面上发现。 提供分离或纯化形式的ULBP多肽的哺乳动物形式。 此外，提供了编码ULBP多肽的分离的核酸和包含编码ULBP多肽的cDNA的表达载体。 ULBP多肽可以被分离或合成并用于制备针对多肽的抗体，特别是单克隆抗体。 抗体又可用于检测人细胞样品中ULBP多肽的存在，这可与患者中恶性病症的存在相关。 ULBP多肽刺激IFN-γ产生，NK细胞增殖和CTL活性。

公开(公告)号：US20110281789A1

公开(公告)日：2011-11-17

申请号：US12862629

申请日：2010-08-24

申请人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

发明人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

IPC分类号： C07K14/435 ,  C12N15/63 ,  C12N5/10 ,  C12N1/19 ,  A61P31/12 ,  C12N1/15 ,  G01N33/574 ,  A61K38/17 ,  A61P35/04 ,  C12N15/11 ,  C12N1/21

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

摘要： The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-γ production, NK cell proliferation, and CTL activity.

摘要翻译： 本发明涉及纯化和分离的新型ULBP多肽，编码此类多肽的核酸，生产此类多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽以及上述用途。 ULBP多肽可以在人B细胞淋巴瘤的表面上发现。 提供分离或纯化形式的ULBP多肽的哺乳动物形式。 此外，提供了编码ULBP多肽的分离的核酸和包含编码ULBP多肽的cDNA的表达载体。 ULBP多肽可以被分离或合成并用于制备针对多肽的抗体，特别是单克隆抗体。 抗体又可用于检测人细胞样品中ULBP多肽的存在，这可与患者中恶性病症的存在相关。 ULBP多肽刺激IFN-γ产生，NK细胞增殖和CTL活性。

公开(公告)号：US20090324597A1

公开(公告)日：2009-12-31

申请号：US12221490

申请日：2008-08-04

申请人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

发明人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/06

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

摘要： The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-γ production, NK cell proliferation, and CTL activity.

摘要翻译： 本发明涉及纯化和分离的新型ULBP多肽，编码此类多肽的核酸，生产此类多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽以及上述用途。 ULBP多肽可以在人B细胞淋巴瘤的表面上发现。 提供分离或纯化形式的ULBP多肽的哺乳动物形式。 此外，提供了编码ULBP多肽的分离的核酸和包含编码ULBP多肽的cDNA的表达载体。 ULBP多肽可以被分离或合成并用于制备针对多肽的抗体，特别是单克隆抗体。 抗体又可用于检测人细胞样品中ULBP多肽的存在，这可与患者中恶性病症的存在相关。 ULBP多肽刺激IFN-γ产生，NK细胞增殖和CTL活性。

公开(公告)号：US06653447B1

公开(公告)日：2003-11-25

申请号：US09524100

申请日：2000-03-13

申请人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

发明人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

IPC分类号： C07K100

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

摘要： The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-&ggr; production, NK cell proliferation, and CTL activity.

公开(公告)号：US07427669B2

公开(公告)日：2008-09-23

申请号：US11638966

申请日：2006-12-13

申请人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

发明人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

IPC分类号： C07K16/00 ,  C12P21/08 ,  C12N5/06

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

摘要： The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-γ production, NK cell proliferation, and CTL activity.

摘要翻译： 本发明涉及纯化和分离的新型ULBP多肽，编码此类多肽的核酸，生产此类多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽以及上述用途。 ULBP多肽可以在人B细胞淋巴瘤的表面上发现。 提供分离或纯化形式的ULBP多肽的哺乳动物形式。 此外，提供了编码ULBP多肽的分离的核酸和包含编码ULBP多肽的cDNA的表达载体。 ULBP多肽可以被分离或合成并用于制备针对多肽的抗体，特别是单克隆抗体。 抗体又可用于检测人细胞样品中ULBP多肽的存在，这可与患者中恶性病症的存在相关。 ULBP多肽刺激IFN-γ产生，NK细胞增殖和CTL活性。

公开(公告)号：US06458350B1

公开(公告)日：2002-10-01

申请号：US09532856

申请日：2000-03-22

申请人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

发明人： David J. Cosman ,  Jurgen Mullberg ,  William C. Fanslow, III ,  Marek Kubin ,  Richard Jeffrey Armitage

IPC分类号： A61K4500

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

摘要： The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-&ggr; production, NK cell proliferation, and CTL activity.

摘要翻译： 本发明涉及纯化和分离的新型ULBP多肽，编码此类多肽的核酸，生产此类多肽的重组形式的方法，针对这些多肽产生的抗体，衍生自这些多肽的片段化肽以及上述用途。 ULBP多肽可以在人B细胞淋巴瘤的表面上发现。 提供分离或纯化形式的ULBP多肽的哺乳动物形式。 此外，提供了编码ULBP多肽的分离的核酸和包含编码ULBP多肽的cDNA的表达载体。 ULBP多肽可以被分离或合成并用于制备针对多肽的抗体，特别是单克隆抗体。 抗体又可用于检测人细胞样品中ULBP多肽的存在，这可与患者中恶性病症的存在相关。 ULBP多肽刺激IFN-γ产生，NK细胞增殖和CTL活性。