公开(公告)号：US5194246A

公开(公告)日：1993-03-16

申请号：US686106

申请日：1991-04-16

申请人： Carol K. Vincent ,  David L. Elliott ,  Catherine L. Howie-Meyers

发明人： Carol K. Vincent ,  David L. Elliott ,  Catherine L. Howie-Meyers

IPC分类号： A61K8/81 ,  A61Q11/00

CPC分类号： A61K8/8164 ,  A61K8/8147 ,  A61Q11/00 ,  A61K2800/594

摘要： A method and composition for controlling calculus formation in the mouth is reported based upon a combination of a low and high molecular weight polymer. The first polymer is a synthetic anionic polymer having a molecular weight of at least 4000. The second polymer has a molecular weight up to about 2500 and is formed from a mixture of mono- and di- carboxylic vinyl monomers reacted with hypophosphite groups.

公开(公告)号：US5143719A

公开(公告)日：1992-09-01

申请号：US686208

申请日：1991-04-16

申请人： David L. Elliott ,  Catherine L. Howie-Meyers

发明人： David L. Elliott ,  Catherine L. Howie-Meyers

IPC分类号： A61K8/24 ,  A61K8/81 ,  A61Q11/00

CPC分类号： A61K8/8164 ,  A61K8/24 ,  A61Q11/00 ,  A61K2800/57

摘要： A method and composition for controlling calculus formation in the mouth is reported based upon a combination of inorganic polyphosphates and certain low molecular weight copolymers. These copolymers are formed from a mixture of mono- and di-carboxylic vinyl monomers reacted with hypophosphite groups. Particularly effective are phosphorous containing acrylate/maleate polymers of weight averaged molecular weight ranging from about 400 to 5000.