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公开(公告)号：US5783213A
公开(公告)日：1998-07-21
申请号：US811812
申请日：1997-03-06
CPC分类号： A61K9/0004
摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.
摘要翻译： 本发明涉及渗透输送装置的改进，其中该装置包括包含乙酸丁酸纤维素的半透壁，并包围含有有益剂或药物制剂的内部隔室，流体活化的可膨胀驱动构件， 试剂配方和驱动构件，以及任选的密封构件和在半透壁中的出口装置; 并且其中改进包括具有差示扫描量热法（“DSC”）轮廓的半透膜的乙酸丁酸纤维素成分，其中主DSC或DSC主峰具有在228℃以上的最小温度峰，并且二次DSC峰面积相等 小于或等于初级和次级DSC峰的总合合面积的约30％。 本发明还涉及由具有差示扫描量热法（“DSC”）分布的醋酸丁酸纤维素制备的改进的半透膜，其中主DSC峰值高于228℃，二次DSC峰面积等于或小于 超过了主要和次要DSC峰总面积的约30％，半透膜对于渗透输送装置提供了显着改进的均匀快速启动性能。
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公开(公告)号：US5607696A
公开(公告)日：1997-03-04
申请号：US441888
申请日：1995-05-16
CPC分类号： A61K9/0004
摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.
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公开(公告)号：US5609885A
公开(公告)日：1997-03-11
申请号：US387967
申请日：1995-02-10
CPC分类号： A61K9/0004
摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.
摘要翻译： 本发明涉及渗透输送装置的改进，其中该装置包括包含乙酸丁酸纤维素的半透壁，并包围含有有益剂或药物制剂的内部隔室，流体活化的可膨胀驱动构件， 试剂配方和驱动构件，以及任选的密封构件和在半透壁中的出口装置; 并且其中改进包括具有差示扫描量热法（“DSC”）轮廓的半透膜的乙酸丁酸纤维素成分，其中主DSC或DSC主峰具有在228℃以上的最小温度峰，并且二次DSC峰面积相等 小于或等于初级和次级DSC峰的总合合面积的约30％。 本发明还涉及由具有差示扫描量热法（“DSC”）分布的醋酸丁酸纤维素制备的改进的半透膜，其中主DSC峰值高于228℃，二次DSC峰面积等于或小于 超过了主要和次要DSC峰总面积的约30％，半透膜对于渗透输送装置提供了显着改进的均匀快速启动性能。
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公开(公告)号：US4731122A
公开(公告)日：1988-03-15
申请号：US31824
申请日：1987-03-30
CPC分类号： A61K9/2054 , C08L1/10
摘要： The invention concerns a process for producing a thermoplastic composition comprising a cellulose ester.
摘要翻译： 本发明涉及一种生产包含纤维素酯的热塑性组合物的方法。
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公开(公告)号：US20110230865A1
公开(公告)日：2011-09-22
申请号：US13116970
申请日：2011-05-26
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Bonnie J. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Bonnie J. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61M37/00
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译： 本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。 不可渗透的储存器分为水溶胀剂室和活性剂配制室。 来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。 交付期限达2年。
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公开(公告)号：US06395292B2
公开(公告)日：2002-05-28
申请号：US09848211
申请日：2001-05-04
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
IPC分类号： A61F200
CPC分类号： A61M5/14526 , A61K9/0004 , A61K9/0024 , A61K38/09 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
摘要翻译： 本发明涉及一种用于在预定给药期间递送活性剂制剂的装置。 不可渗透的储存器分为水溶胀剂室和活性剂配制室。 来自环境的流体通过半渗透塞吸入水溶胀剂室中，活性剂制剂通过反向扩散调节出口释放。 交付期限达2年。
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公开(公告)号：US06180129B2
公开(公告)日：2001-01-30
申请号：US08956424
申请日：1997-10-23
IPC分类号： A61K914
CPC分类号： A61K9/0004 , A61M31/002
摘要： A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.
摘要翻译： 公开了用于将有益剂递送到动物的递送系统。 递送系统包括围绕内腔的壁，所述壁包括限制流体进入系统的组合物和允许流体进入系统的组合物。 管腔包括有益剂和可膨胀构件。 递送系统包括用于递送有益剂的出口装置。
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公开(公告)号：US5985305A
公开(公告)日：1999-11-16
申请号：US943007
申请日：1997-10-02
申请人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
发明人： John R. Peery , Keith E. Dionne , James B. Eckenhoff , Felix A. Landrau , Scott D. Lautenbach , Judy A. Magruder , Jeremy C. Wright
CPC分类号： A61K9/0004 , A61K38/09 , A61K9/0024 , A61M5/14526 , A61M2005/14513 , A61M2206/10
摘要： The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
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公开(公告)号：US5474785A
公开(公告)日：1995-12-12
申请号：US092301
申请日：1993-07-15
CPC分类号： A61K9/0068 , A61K9/0004
摘要： The present invention is directed to an improvement in a delivery system, the system comprising a wall that surrounds an internal lumen or compartment which contains a thermo-responsive beneficial agent formulation, an expandable driving member and an optional density member, and having an exit opening, and wherein the improvement comprises a) a viscosity-inducing amount of an inert viscosity-inducing agent in the thermo-responsive beneficial agent composition for increasing the viscosity of the beneficial agent composition, and/or b) a pressure-inducing exit member in the exit opening in the wall for increasing the pressure inside the lumen.
摘要翻译： 本发明涉及递送系统的改进，该系统包括围绕包含热响应有益剂制剂的内腔或隔室的壁，可膨胀驱动构件和任选的密封构件，并且具有出口 并且其中改进包括a）在用于增加有益剂组合物的粘度的热响应有益剂组合物中的惰性粘度诱导剂的粘度诱导量，和/或b）压力诱导出口部件 壁中的出口开口用于增加内腔内的压力。
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公开(公告)号：US5229133A
公开(公告)日：1993-07-20
申请号：US850087
申请日：1992-03-12
IPC分类号： A61K9/00
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a semipermeable housing defining a internal space, (2) an optional and presently preferred in the space, (3) a heat responsive composition comprising a beneficial agent in the space, (4) a space consuming member in the device, (5) a non-toxic compound blended with the heat responsive composition for enhancing its viscosity; (6) an exit port in the wall for increasing the internal pressure of the dispenser and for simultaneously letting the beneficial agent exit through said port from the device, and (7) an embodiment comprising a prehydrating fluid for fastening the start-up of delivery from the delivery system.
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