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    Osmotic membrane and delivery device
    1.
    发明授权
    Osmotic membrane and delivery device 失效
    渗透膜和输送装置

    公开(公告)号：US5609885A

    公开(公告)日：1997-03-11

    申请号：US387967

    申请日：1995-02-10

    申请人： David L. Rivera ,  Sonya Merrill ,  James B. Eckenhoff ,  Jeremy C. Wright ,  James L. Osborne

    发明人： David L. Rivera ,  Sonya Merrill ,  James B. Eckenhoff ,  Jeremy C. Wright ,  James L. Osborne

    IPC分类号： A61K9/00 ,  A61K9/24

    CPC分类号： A61K9/0004

    摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.

    摘要翻译： 本发明涉及渗透输送装置的改进，其中该装置包括包含乙酸丁酸纤维素的半透壁，并包围含有有益剂或药物制剂的内部隔室，流体活化的可膨胀驱动构件， 试剂配方和驱动构件，以及任选的密封构件和在半透壁中的出口装置; 并且其中改进包括具有差示扫描量热法（“DSC”）轮廓的半透膜的乙酸丁酸纤维素成分，其中主DSC或DSC主峰具有在228℃以上的最小温度峰，并且二次DSC峰面积相等 小于或等于初级和次级DSC峰的总合合面积的约30％。 本发明还涉及由具有差示扫描量热法（“DSC”）分布的醋酸丁酸纤维素制备的改进的半透膜，其中主DSC峰值高于228℃，二次DSC峰面积等于或小于 超过了主要和次要DSC峰总面积的约30％，半透膜对于渗透输送装置提供了显着改进的均匀快速启动性能。

    Osmotic membrane and delivery device
    2.
    发明授权
    Osmotic membrane and delivery device 失效
    渗透膜和输送装置

    公开(公告)号：US5783213A

    公开(公告)日：1998-07-21

    申请号：US811812

    申请日：1997-03-06

    申请人： David L. Rivera ,  Sonya Merrill ,  James B. Eckenhoff ,  Jeremy C. Wright ,  James L. Osborne

    发明人： David L. Rivera ,  Sonya Merrill ,  James B. Eckenhoff ,  Jeremy C. Wright ,  James L. Osborne

    IPC分类号： A61K9/00 ,  A61K9/24

    CPC分类号： A61K9/0004

    摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.

    摘要翻译： 本发明涉及渗透输送装置的改进，其中该装置包括包含乙酸丁酸纤维素的半透壁，并包围含有有益剂或药物制剂的内部隔室，流体活化的可膨胀驱动构件， 试剂配方和驱动构件，以及任选的密封构件和在半透壁中的出口装置; 并且其中改进包括具有差示扫描量热法（“DSC”）轮廓的半透膜的乙酸丁酸纤维素成分，其中主DSC或DSC主峰具有在228℃以上的最小温度峰，并且二次DSC峰面积相等 小于或等于初级和次级DSC峰的总合合面积的约30％。 本发明还涉及由具有差示扫描量热法（“DSC”）分布的醋酸丁酸纤维素制备的改进的半透膜，其中主DSC峰值高于228℃，二次DSC峰面积等于或小于 超过了主要和次要DSC峰总面积的约30％，半透膜对于渗透输送装置提供了显着改进的均匀快速启动性能。

    Osmotic membrane and delivery device
    3.
    发明授权
    Osmotic membrane and delivery device 失效

    公开(公告)号：US5607696A

    公开(公告)日：1997-03-04

    申请号：US441888

    申请日：1995-05-16

    申请人： David L. Rivera ,  Sonya Merrill ,  James B. Eckenhoff ,  Jeremy C. Wright ,  James L. Osborne

    发明人： David L. Rivera ,  Sonya Merrill ,  James B. Eckenhoff ,  Jeremy C. Wright ,  James L. Osborne

    IPC分类号： A61K9/00 ,  A61K9/24

    CPC分类号： A61K9/0004

    摘要： The present invention relates to an improvement in an osmotic delivery device wherein the device comprises a semipermeable wall comprising cellulose acetate butyrate and surrounding an internal compartment containing a beneficial agent or medicament formulation, a fluid-activated expandable driving member, optionally a partition layer between the agent formulation and the driving member, and, optionally a density member, and exit means in the semipermeable wall; and wherein the improvement comprises the cellulose acetate butyrate component of the semipermeable wall having a differential scanning calorimetry ("DSC") profile wherein the main or primary DSC peak has a minimum temperature peak above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined areas of the primary and secondary DSC peaks. The invention also relates to the improved semipermeable membrane produced from cellulose acetate butyrate having a differential scanning calorimetry ("DSC") profile wherein the main DSC peak is at a temperature above 228.degree. C. and the secondary DSC peak area is equal to or less than about 30% of the total combined area of the primary and secondary DSC peaks, the semipermeable membrane providing a substantially improved uniform rapid startup performance for osmotic delivery devices.

    Osmotically driven delivery device with expandable orifice for pulsatile delivery effect
    7.
    发明授权
    Osmotically driven delivery device with expandable orifice for pulsatile delivery effect 失效
    渗透式输送装置，具有可扩展的孔口用于脉动输送效果

    公开(公告)号：US5318558A

    公开(公告)日：1994-06-07

    申请号：US984387

    申请日：1992-12-01

    申请人： Andreas Linkwitz ,  Judy A. Magruder ,  Sonya Merrill

    发明人： Andreas Linkwitz ,  Judy A. Magruder ,  Sonya Merrill

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： A drug delivery capsule from which the delivery of the drug is driven by the osmotic infusion of moisture by the capsule from a physiological environment is provided with a delivery orifice which opens intermittently to achieve a pulsatile delivery effect. The wall in which the orifice is formed is constructed of an elastic material, preferably an elastomer, which stretches under a pressure differential caused by the pressure rise inside the capsule as the osmotic infusion progresses. The orifice is small enough that when the elastic wall is relaxed, the flow rate of drug through the orifice is substantially zero, but that when the elastic wall is stretched due to the pressure differential across the wall exceeding a threshold, the orifice expands sufficiently to allow the release of the drug at a physiologically beneficial rate.

    摘要翻译： 由胶囊从生理环境渗透输入药物驱动的药物递送胶囊设置有间歇地打开以实现脉动递送效果的输送孔。 其中形成孔的壁由弹性材料构成，弹性材料优选为弹性体，该弹性材料在渗透输液进行时由胶囊内部的压力升高引起的压差下伸展。 孔口足够小，使得当弹性壁松弛时，通过孔口的药物的流速基本上为零，但是当由于壁上的压力差超过阈值而使弹性壁拉伸时，孔口充分扩张到 允许以生理有益的速率释放药物。