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公开(公告)号:US08314257B2
公开(公告)日:2012-11-20
申请号:US12232447
申请日:2008-09-17
申请人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
发明人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
IPC分类号: C07D215/38 , A61K31/04
CPC分类号: C07D209/12 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/4709 , A61K31/498 , C07D209/08 , C07D209/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.
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公开(公告)号:US08198314B2
公开(公告)日:2012-06-12
申请号:US12232446
申请日:2008-09-17
申请人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
发明人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
IPC分类号: C07D215/38 , A61K31/04
CPC分类号: C07D209/12 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/4709 , A61K31/498 , C07D209/08 , C07D209/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.
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公开(公告)号:US08163931B2
公开(公告)日:2012-04-24
申请号:US12232444
申请日:2008-09-17
申请人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
发明人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
IPC分类号: C07D215/38
CPC分类号: C07D209/12 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/4709 , A61K31/498 , C07D209/08 , C07D209/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.
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4.Compounds for the treatment of CRTH2-mediated diseases and conditions 有权
标题翻译: 用于治疗CRTH2介导的疾病和病症的化合物公开(公告)号:US07582672B2
公开(公告)日:2009-09-01
申请号:US10972060
申请日:2004-10-22
申请人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Eric R. Pettipher , Michael George Hunter , Mark Whittaker , Chris Palmer
发明人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Eric R. Pettipher , Michael George Hunter , Mark Whittaker , Chris Palmer
IPC分类号: A61K31/405 , C07D417/00
CPC分类号: C07D209/12 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/4709 , A61K31/498 , C07D209/08 , C07D209/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.
摘要翻译: 本发明提供了拮抗前列腺素D2的吲哚衍生物,其可用于治疗由前列腺素D2介导的炎性疾病。
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公开(公告)号:US08163936B2
公开(公告)日:2012-04-24
申请号:US12232445
申请日:2008-09-17
申请人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
发明人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
IPC分类号: C07D215/38
CPC分类号: C07D209/12 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/4709 , A61K31/498 , C07D209/08 , C07D209/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.
摘要翻译: 本发明提供了拮抗前列腺素D2的吲哚衍生物,其可用于治疗由前列腺素D2介导的炎性疾病。
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公开(公告)号:US20090018338A1
公开(公告)日:2009-01-15
申请号:US12232445
申请日:2008-09-17
申请人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
发明人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
IPC分类号: C07D401/02 , C07D209/04
CPC分类号: C07D209/12 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/4709 , A61K31/498 , C07D209/08 , C07D209/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.
摘要翻译: 本发明提供了拮抗前列腺素D2的吲哚衍生物,其可用于治疗由前列腺素D2介导的炎性疾病。
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公开(公告)号:US20090018139A1
公开(公告)日:2009-01-15
申请号:US12232447
申请日:2008-09-17
申请人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
发明人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
IPC分类号: A61K31/404 , A61K31/498 , A61K31/426 , A61K31/427 , C07D209/06 , C07D401/02 , C07D403/02 , C07D417/02 , A61P11/00
CPC分类号: C07D209/12 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/4709 , A61K31/498 , C07D209/08 , C07D209/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.
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公开(公告)号:US20090018138A1
公开(公告)日:2009-01-15
申请号:US12232446
申请日:2008-09-17
申请人: David Middlemiss , Mark Richard Ashton , Edward Andrew boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
发明人: David Middlemiss , Mark Richard Ashton , Edward Andrew boyd , Frederick Arthur Brookfield , Michael George Hunter , Mark Whittaker , Chris Palmer , Eric R. Pettipher
IPC分类号: A61K31/404 , A61P11/00 , A61P17/00 , A61K31/498 , A61K31/427 , A61K31/426 , A61K31/4709 , A61P29/00
CPC分类号: C07D209/12 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/4709 , A61K31/498 , C07D209/08 , C07D209/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.
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公开(公告)号:US20090023788A1
公开(公告)日:2009-01-22
申请号:US12232444
申请日:2008-09-17
申请人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Eric Roy Pettipher , Michael George Hunter , Mark Whittaker , Chris Palmer
发明人: David Middlemiss , Mark Richard Ashton , Edward Andrew Boyd , Frederick Arthur Brookfield , Eric Roy Pettipher , Michael George Hunter , Mark Whittaker , Chris Palmer
IPC分类号: A61K31/428 , A61K31/404 , A61P11/00 , A61P37/08 , A61P19/02
CPC分类号: C07D209/12 , A61K31/404 , A61K31/426 , A61K31/428 , A61K31/4709 , A61K31/498 , C07D209/08 , C07D209/10 , C07D401/06 , C07D403/06 , C07D417/06
摘要: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.
摘要翻译: 本发明提供了拮抗前列腺素D2的吲哚衍生物,其可用于治疗由前列腺素D2介导的炎性疾病。
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10.Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them 有权
标题翻译: 作为激酶抑制剂活性的吡咯并[2,3-b]吡啶衍生物和包含它们的药物组合物公开(公告)号:US07728140B2
公开(公告)日:2010-06-01
申请号:US11020793
申请日:2004-12-23
申请人: Barbara Salom , Matteo D'Anello , Maria Gabriella Brasca , Patrizia Giordano , Katia Martina , Francesco Angelucci , Frederick Arthur Brookfield , William John Trigg , Edward Andrew Boyd , Jonathan Anthony Larard
发明人: Barbara Salom , Matteo D'Anello , Maria Gabriella Brasca , Patrizia Giordano , Katia Martina , Francesco Angelucci , Frederick Arthur Brookfield , William John Trigg , Edward Andrew Boyd , Jonathan Anthony Larard
IPC分类号: C07D471/02
CPC分类号: C07D471/04
摘要: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
摘要翻译: 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物,其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症,细胞增殖性疾病,阿尔茨海默病,病毒感染,自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。
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