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    OPTICAL SENSOR CONFIGURATION AND METHODS FOR MONITORING GLUCOSE ACTIVITY IN INTERSTITIAL FLUID
    2.
    发明申请
    OPTICAL SENSOR CONFIGURATION AND METHODS FOR MONITORING GLUCOSE ACTIVITY IN INTERSTITIAL FLUID 审中-公开
    光学传感器配置和监测间接流体中葡萄糖活性的方法

    公开(公告)号：US20120053427A1

    公开(公告)日：2012-03-01

    申请号：US13221696

    申请日：2011-08-30

    申请人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser ,  William Markle

    发明人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser ,  William Markle

    IPC分类号： A61B5/1459 ,  A61B5/01

    CPC分类号： A61B5/14532 ,  A61B5/1459

    摘要： Embodiments of the invention are directed to an optical sensor for detecting blood glucose by deploying the optical sensor into the interstitial fluid. The sensor comprises a chemical indicator system capable of generating an optical signal related to the blood glucose activity. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose activity, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.

    摘要翻译： 本发明的实施例涉及一种用于通过将光学传感器部署到组织液中来检测血糖的光学传感器。 传感器包括能够产生与血糖活性相关的光学信号的化学指示器系统。 传感器还包括用于产生和检测与血糖活动无关的光学参考信号的装置，使得能够对光学系统中的伪影进行血糖测量的比例校正。

    Apparatus and methods for non-invasively measuring hemodynamic parameters
    5.
    发明申请
    Apparatus and methods for non-invasively measuring hemodynamic parameters 审中-公开
    非侵入性测量血液动力学参数的装置和方法

    公开(公告)号：US20050080345A1

    公开(公告)日：2005-04-14

    申请号：US10920999

    申请日：2004-08-18

    申请人： Simon Finburgh ,  Russell Hempstead ,  Mark Perona ,  Ronald Vidischak ,  William Markle ,  Allison Porreco ,  Anthony Butler

    发明人： Simon Finburgh ,  Russell Hempstead ,  Mark Perona ,  Ronald Vidischak ,  William Markle ,  Allison Porreco ,  Anthony Butler

    IPC分类号： A61B5/021 ,  A61B5/02

    CPC分类号： A61B5/021 ,  A61B5/022 ,  A61B5/681 ,  A61B5/6824 ,  A61B5/6843

    摘要： Improved apparatus and methods for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises apparatus adapted to accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject, including an alignment apparatus which is separable from an adjustable fixture. The alignment apparatus moveably captures the sensor to, inter alia, facilitate coupling thereof to an actuator used to position the sensor during measurements. The alignment apparatus also advantageously allows the sensor position to be maintained when the fixture is removed from the subject, such as during patient transport. Methods for positioning the alignment apparatus and sensor, correcting for hydrostatic pressure effects, and providing treatment to the subject are also disclosed.

    摘要翻译： 用于非侵入性评估与生物体的循环系统相关的一个或多个血液动力学参数的改进的装置和方法。 在一个方面，本发明包括适于相对于对象的解剖结构精确地放置和维持传感器（例如，压力测量压力传感器）的装置，包括可调节固定装置的对准装置。 对准装置可移动地捕获传感器，尤其是便于将其耦合到用于在测量期间定位传感器的致动器。 对准装置还有利地允许当夹具从受试者移除时（例如在患者运送期间）保持传感器位置。 还公开了用于定位对准装置和传感器，校正静水压力效应以及为受试者提供治疗的方法。