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    Sensor for percutaneous intravascular deployment without an indwelling cannula
    1.
    发明授权
    Sensor for percutaneous intravascular deployment without an indwelling cannula 有权
    用于经皮血管内部署的传感器，无需留置插管

    公开(公告)号：US08512245B2

    公开(公告)日：2013-08-20

    申请号：US12424902

    申请日：2009-04-16

    申请人： David R. Markle ,  William H. Markle

    发明人： David R. Markle ,  William H. Markle

    IPC分类号： A61B5/1459 ,  A61B5/145 ,  A61B17/34

    CPC分类号： A61B5/1459 ,  A61B5/14532 ,  A61B5/14542 ,  A61M25/0668

    摘要： The present invention relates to a sensor for percutaneous insertion and intravascular residence without an indwelling cannula. In preferred embodiments, a glucose sensor is inserted into a blood vessel using a removable cannula. After the cannula is removed, the glucose sensor remains within the blood vessel by itself and forms a seal with the patient's tissue.

    摘要翻译： 本发明涉及一种用于经皮插入和没有留置插管的血管内存活的传感器。 在优选实施例中，使用可移除的套管将葡萄糖传感器插入血管。 在插管被移除之后，葡萄糖传感器本身保持在血管内并与患者的组织形成密封。

    Optical sensor configuration for ratiometric correction of blood glucose measurement
    2.
    发明授权
    Optical sensor configuration for ratiometric correction of blood glucose measurement 有权
    血糖测量比例校正的光学传感器配置

    公开(公告)号：US08467843B2

    公开(公告)日：2013-06-18

    申请号：US12612602

    申请日：2009-11-04

    申请人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    发明人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14532 ,  A61B5/1459 ,  A61B5/14735 ,  A61B2562/0238 ,  A61B2562/043 ,  G01N21/7703 ,  G01N2021/7786

    摘要： Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.

    摘要翻译： 本发明的实施例涉及一种用于检测血糖的光学传感器。 该传感器包括一个化学指示器系统，该化学指示器系统设置在光纤的远端和无损伤尖端部分之间的间隙内，其中光纤和无创尖端部分通过耦合部件耦合，例如杆或海波管或笼， 差距。 传感器还包括用于产生和检测与血糖无关的光学参考信号的装置，使得能够对光学系统中的伪影进行血糖测量的比例校正。

    USE OF AN EQUILIBRIUM INTRAVASCULAR SENSOR TO ACHIEVE TIGHT GLYCEMIC CONTROL
    3.
    发明申请
    USE OF AN EQUILIBRIUM INTRAVASCULAR SENSOR TO ACHIEVE TIGHT GLYCEMIC CONTROL 有权
    使用平均血管内传感器实现轻度控制

    公开(公告)号：US20120116191A1

    公开(公告)日：2012-05-10

    申请号：US13316397

    申请日：2011-12-09

    申请人： William H. Markle ,  David R. Markle

    发明人： William H. Markle ,  David R. Markle

    IPC分类号： A61B5/1459

    CPC分类号： A61B5/14532 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/412 ,  A61M5/16827 ,  A61M5/1723

    摘要： A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.

    摘要翻译： 公开了一种在有需要的患者中实现紧密血糖控制的方法。 该方法包括将平衡葡萄糖传感器布置在患者的血管内，将传感器耦合到显示血糖浓度的监测器，以及当血糖浓度在预定浓度范围之外变化时施用血糖调节剂。 以足以将血糖浓度返回到预定浓度范围内的量施用血糖调节剂，由此实现严格的血糖控制。

    Method for assembling package for an active medical device
    5.
    发明授权
    Method for assembling package for an active medical device 失效
    用于组装主动医疗装置的包装的方法

    公开(公告)号：US5357732A

    公开(公告)日：1994-10-25

    申请号：US64615

    申请日：1993-05-20

    申请人： David R. Markle ,  Stuart P. Hendry ,  Michael P. Irvine

    发明人： David R. Markle ,  Stuart P. Hendry ,  Michael P. Irvine

    IPC分类号： B65D81/24 ,  A61B5/00 ,  A61B19/02 ,  B65B31/02 ,  B65B5/08 ,  B65B61/00

    CPC分类号： A61B5/145 ,  A61B50/30 ,  A61B2050/005 ,  A61B50/33 ,  Y10S439/912

    摘要： A method for assembling a package for an active medical device which comprises making an opening in a wall of a recess shaped to receive the device, placing a gasket against the wall and about a band mounted through a flat portion of the wall, inserting the band through the opening so the gasket is flush against the wall, installing an outer part about the band to hold the gasket against the wall to form a sterile barrier, and placing a lid over the recess to contain the device within a sterile field.

    摘要翻译： 一种用于组装用于主动医疗装置的包装件的方法，包括在形状为接收所述装置的凹部的壁中形成开口，将衬垫放置在壁上并围绕安装在壁的平坦部分上的带上，将带 通过开口使得垫圈与壁齐平，围绕带安装外部部分以将垫圈保持抵靠壁以形成无菌屏障，并将盖放置在凹部上以将该装置容纳在无菌区域内。

    Use of an equilibrium intravascular sensor to achieve tight glycemic control
    8.
    发明授权
    Use of an equilibrium intravascular sensor to achieve tight glycemic control 有权
    使用平衡血管内传感器实现严格的血糖控制

    公开(公告)号：US08535262B2

    公开(公告)日：2013-09-17

    申请号：US13316397

    申请日：2011-12-09

    申请人： William H. Markle ,  David R. Markle

    发明人： William H. Markle ,  David R. Markle

    IPC分类号： A61M31/00

    CPC分类号： A61B5/14532 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/412 ,  A61M5/16827 ,  A61M5/1723

    摘要： A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.

    摘要翻译： 公开了一种在有需要的患者中实现紧密血糖控制的方法。 该方法包括将平衡葡萄糖传感器布置在患者的血管内，将传感器耦合到显示血糖浓度的监测器，以及当血糖浓度在预定浓度范围之外变化时施用血糖调节剂。 以足以将血糖浓度返回到预定浓度范围内的量施用血糖调节剂，由此实现严格的血糖控制。

    OPTICAL SENSOR CONFIGURATION FOR RATIOMETRIC CORRECTION OF BLOOD GLUCOSE MEASUREMENT
    10.
    发明申请
    OPTICAL SENSOR CONFIGURATION FOR RATIOMETRIC CORRECTION OF BLOOD GLUCOSE MEASUREMENT 有权
    用于血糖测量的比例校正的光传感器配置

    公开(公告)号：US20110105866A1

    公开(公告)日：2011-05-05

    申请号：US12612602

    申请日：2009-11-04

    申请人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    发明人： David R. Markle ,  Soya Gamsey ,  Thomas A. Peyser

    IPC分类号： A61B5/1459

    CPC分类号： A61B5/14532 ,  A61B5/1459 ,  A61B5/14735 ,  A61B2562/0238 ,  A61B2562/043 ,  G01N21/7703 ,  G01N2021/7786

    摘要： Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.

    摘要翻译： 本发明的实施例涉及一种用于检测血糖的光学传感器。 该传感器包括一个化学指示器系统，该化学指示器系统设置在光纤的远端和无损伤尖端部分之间的间隙内，其中光纤和无创尖端部分通过耦合部件耦合，例如杆或海波管或笼， 差距。 传感器还包括用于产生和检测与血糖无关的光学参考信号的装置，使得能够对光学系统中的伪影进行血糖测量的比例校正。