公开(公告)号：US20050027351A1

公开(公告)日：2005-02-03

申请号：US10742747

申请日：2003-12-19

申请人： David Reuter ,  Gregory Nieminen ,  Nathan Aronson ,  Lucas Gordon ,  Garrett Beget ,  Clif Alferness ,  Mark Mathis

发明人： David Reuter ,  Gregory Nieminen ,  Nathan Aronson ,  Lucas Gordon ,  Garrett Beget ,  Clif Alferness ,  Mark Mathis

IPC分类号： A61F2/24

CPC分类号： A61F2/2451 ,  Y10S623/904

摘要： A method of treating regurgitation of a mitral valve in a patient's heart. The method includes the steps of: delivering a tissue shaping device to the coronary sinus; and deploying the tissue shaping device to reduce mitral valve regurgitation, the deploying step comprising applying a force through the coronary sinus wall toward the mitral valve solely proximal to a crossover point where a coronary artery passes between a coronary sinus and the mitral valve. The invention is also a set of devices for use in treating mitral valve regurgitation. The set includes a plurality of tissue shaping devices having different lengths, each of the tissue shaping devices being configured to be deliverable to a coronary sinus of a patient within a catheter having an outer diameter no greater than ten french.

摘要翻译： 治疗患者心脏二尖瓣反流的方法。 该方法包括以下步骤：将组织整形装置递送至冠状窦; 并且展开所述组织整形装置以减少二尖瓣反流，所述展开步骤包括仅通过冠状动脉穿过冠状窦和二尖瓣之间的交叉点向二尖瓣施加穿过冠状窦壁的力。 本发明也是用于治疗二尖瓣反流的一组装置。 该组包括具有不同长度的多个组织整形装置，每个组织整形装置构造成可输送到具有不超过十个法兰的外径的导管内的患者的冠状窦。

公开(公告)号：US20050137685A1

公开(公告)日：2005-06-23

申请号：US10742519

申请日：2003-12-19

申请人： Gregory Nieminen ,  David Reuter ,  Nathan Aronson ,  Lucas Gordon ,  Garrett Beget

发明人： Gregory Nieminen ,  David Reuter ,  Nathan Aronson ,  Lucas Gordon ,  Garrett Beget

IPC分类号： A61F2/24

CPC分类号： A61F2/2451

摘要： One aspect of the invention is a method of treating mitral valve regurgitation in a patient. The method includes the steps of delivering a tissue shaping device to the patient's coronary sinus in an unexpanded configuration within a catheter having an outer diameter no more than nine or ten french, with the tissue shaping device including a connector disposed between a distal expandable anchor comprising flexible wire and a proximal expandable anchor comprising flexible wire, the device having a length of 60 mm or less; and deploying the device to reduce mitral valve regurgitation, such as by anchoring the distal expandable anchor by placing the distal expandable anchor flexible wire in contact with a wall of the coronary sinus, e.g., by permitting the distal expandable anchor to self-expand or by applying an actuating force to the distal expandable anchor and possibly locking the distal expandable anchor after performing the applying step. The invention also includes a device for performing the method.

摘要翻译： 本发明的一个方面是治疗患者二尖瓣关闭不全的方法。 该方法包括以下步骤：将组织成形装置以不超过9或10法兰的外径的导管内的未展开构造递送到患者的冠状窦，其中组织整形装置包括连接器，该连接器设置在包括 柔性线和包括柔性线的近端可扩展锚，该装置具有60mm或更小的长度; 并且部署该装置以减少二尖瓣反流，例如通过将远端可扩张锚定柔性线与冠状窦的壁接触来锚定远端可扩张锚固体，例如通过允许远侧可扩张锚自体扩张或通过 在远程可扩展锚固件施加致动力并且可能在执行施加步骤之后锁定远侧可扩展锚固件。 本发明还包括用于执行该方法的装置。

公开(公告)号：US07837728B2

公开(公告)日：2010-11-23

申请号：US10742519

申请日：2003-12-19

申请人： Gregory Nieminen ,  David Reuter ,  Nathan Aronson ,  Lucas Gordon ,  Garrett Beget

发明人： Gregory Nieminen ,  David Reuter ,  Nathan Aronson ,  Lucas Gordon ,  Garrett Beget

IPC分类号： A61F2/24

CPC分类号： A61F2/2451

摘要： One aspect of the invention is a method of treating mitral valve regurgitation in a patient. The method includes the steps of delivering a tissue shaping device to the patient's coronary sinus in an unexpanded configuration within a catheter having an outer diameter no more than nine or ten french, with the tissue shaping device including a connector disposed between a distal expandable anchor comprising flexible wire and a proximal expandable anchor comprising flexible wire, the device having a length of 60 mm or less; and deploying the device to reduce mitral valve regurgitation, such as by anchoring the distal expandable anchor by placing the distal expandable anchor flexible wire in contact with a wall of the coronary sinus, e.g., by permitting the distal expandable anchor to self-expand or by applying an actuating force to the distal expandable anchor and possibly locking the distal expandable anchor after performing the applying step. The invention also includes a device for performing the method.

摘要翻译： 本发明的一个方面是治疗患者二尖瓣关闭不全的方法。 该方法包括以下步骤：将组织成形装置以不超过9或10法兰的外径的导管内的未展开构造递送到患者的冠状窦，其中组织整形装置包括连接器，该连接器设置在包括 柔性线和包括柔性线的近端可扩展锚，该装置具有60mm或更小的长度; 并且部署该装置以减少二尖瓣反流，例如通过将远端可扩张锚定柔性线与冠状窦的壁接触来锚定远端可扩张锚固体，例如通过允许远侧可扩张锚自体扩张或通过 在远程可扩展锚固件施加致动力并且可能在执行施加步骤之后锁定远侧可扩展锚固件。 本发明还包括用于执行该方法的装置。

公开(公告)号：US20070239270A1

公开(公告)日：2007-10-11

申请号：US11279352

申请日：2006-04-11

申请人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

发明人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

IPC分类号： A61F2/24

CPC分类号： A61F2/2451

摘要： The present invention relates to a medical device and uses thereof that supports or changes the shape of tissue near a vessel in which the device is placed. The present invention is particularly useful in reducing mitral valve regurgitation by changing the shape of or supporting a mitral valve annulus. The device includes a support structure, a proximal anchor adapted to be positioned in a superior vena cava, and a distal anchor adapted to be positioned in a coronary sinus. The support structure engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed.

摘要翻译： 本发明涉及一种医疗装置及其用途，其用于支撑或改变其中放置该装置的血管附近的组织的形状。 本发明特别可用于通过改变二尖瓣环的形状或支撑二尖瓣环来减少二尖瓣反流。 该装置包括支撑结构，适于定位在上腔静脉中的近端锚，以及适于定位在冠状窦中的远侧锚。 支撑结构接合血管壁以改变邻近其中放置血管内支持物的血管的组织的形状。

公开(公告)号：US20080015407A1

公开(公告)日：2008-01-17

申请号：US11782527

申请日：2007-07-24

申请人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

发明人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

IPC分类号： A61F2/00

CPC分类号： A61F2/2451

摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

公开(公告)号：US20080015680A1

公开(公告)日：2008-01-17

申请号：US11782508

申请日：2007-07-24

申请人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

发明人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

IPC分类号： A61F2/06

CPC分类号： A61F2/2451

摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

摘要翻译： 血管内支持装置包括支撑件或再生线，近端锚和远端锚。 支撑线接合血管壁以改变邻近其中放置血管内支架的血管的组织的形状。 锚和支撑线被设计成使得放置支撑件的容器保持打开，并且如果需要可以被其他装置访问。 该装置为在血管内流动的血液提供最小的金属表面积，以限制血栓形成。 锚固件可以锁定到位以将支撑件固定在容器内。

公开(公告)号：US20080015679A1

公开(公告)日：2008-01-17

申请号：US11782490

申请日：2007-07-24

申请人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

发明人： Mark Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

IPC分类号： A61F2/06

CPC分类号： A61F2/2451

摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

公开(公告)号：US20050137449A1

公开(公告)日：2005-06-23

申请号：US10742585

申请日：2003-12-19

申请人： Gregory Nieminen ,  Garrett Beget ,  Nathan Aronson ,  Lucas Gordon

发明人： Gregory Nieminen ,  Garrett Beget ,  Nathan Aronson ,  Lucas Gordon

IPC分类号： A61F2/04 ,  A61F2/24

CPC分类号： A61F2/2451

摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes a distal anchor having a flexible wire with at least one bending point and first and second arms extending from the bending point, the first and second arms being adapted to deform about the bending point; a proximal anchor having a flexible wire with at least one bending point and first and second arms extending from the bending point, the first and second arms being adapted to deform about the bending point; and a connector disposed between the distal anchor and the proximal anchor.

摘要翻译： 一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。 在一些实施例中，该装置包括具有柔性线的远端锚固件，其具有至少一个弯曲点，并且第一和第二臂从弯​​曲点延伸，第一和第二臂适于围绕弯曲点变形; 近端锚具有具有至少一个弯曲点的柔性线，并且从弯曲点延伸的第一和第二臂，第一和第二臂适于围绕弯曲点变形; 以及设置在远端锚固件和近端锚固件之间的连接器。

公开(公告)号：US07503932B2

公开(公告)日：2009-03-17

申请号：US11279352

申请日：2006-04-11

申请人： Mark L. Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

发明人： Mark L. Mathis ,  Gregory Nieminen ,  Nathan Aronson ,  Garrett Beget

IPC分类号： A61F2/06

CPC分类号： A61F2/2451

摘要： The present invention relates to a medical device and uses thereof that supports or changes the shape of tissue near a vessel in which the device is placed. The present invention is particularly useful in reducing mitral valve regurgitation by changing the shape of or supporting a mitral valve annulus. The device includes a support structure, a proximal anchor adapted to be positioned in a superior vena cava, and a distal anchor adapted to be positioned in a coronary sinus. The support structure engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed.

摘要翻译： 本发明涉及一种医疗装置及其用途，其用于支撑或改变其中放置该装置的血管附近的组织的形状。 本发明特别可用于通过改变二尖瓣环的形状或支撑二尖瓣环来减少二尖瓣反流。 该装置包括支撑结构，适于定位在上腔静脉中的近端锚，以及适于定位在冠状窦中的远侧锚。 支撑结构接合血管壁以改变邻近其中放置血管内支持物的血管的组织的形状。

公开(公告)号：US20050137450A1

公开(公告)日：2005-06-23

申请号：US10742600

申请日：2003-12-19

申请人： Nathan Aronson ,  Gregory Nieminen ,  Mark Mathis

发明人： Nathan Aronson ,  Gregory Nieminen ,  Mark Mathis

IPC分类号： A61F2/24 ,  A61F2/86 ,  A61F2/04

CPC分类号： A61F2/2451 ,  A61F2/86

摘要： A tissue shaping device adapted to be disposed in a vessel near a patient's heart to reshape the patient's heart. The tissue shaping device includes a proximal anchor, a distal anchor, and a connector disposed between the proximal anchor and the distal anchor, the connector having a moment of inertia that varies along its length, such as by varying the connector thickness as a function of distance from one of its ends, with the smallest thickness being in the central portion of the connector.

摘要翻译： 一种适于被布置在患者心脏附近的容器中以重塑患者心脏的组织成形装置。 组织成形装置包括近端锚固件，远侧锚固件和设置在近端锚固件和远端锚固件之间的连接器，所述连接器具有沿其长度变化的惯性矩，例如通过改变连接器厚度作为 距离其一端的距离，其中最小的厚度在连接器的中心部分。