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公开(公告)号:US6156744A
公开(公告)日:2000-12-05
申请号:US317906
申请日:1999-05-24
IPC分类号: C07D203/08 , A61K31/396 , C07D403/02 , C07D403/08
CPC分类号: C07D203/08
摘要: The present invention relates to a novel benzoquinone, 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone and its esters. The compounds can be used to treat tumors exhibiting elevated levels of the enzyme DT-diaphorase.
摘要翻译: 本发明涉及一种新的苯醌,2,5-二氮丙啶基-3-(羟甲基)-6-甲基-1,4-苯醌及其酯。 该化合物可用于治疗表现出升高的酶DT-心肌黄酶水平的肿瘤。
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公开(公告)号:US08551964B2
公开(公告)日:2013-10-08
申请号:US12673996
申请日:2008-08-22
IPC分类号: A61K31/704
CPC分类号: C07D225/02 , C07D225/04 , C07D225/06
摘要: The invention provides 19-substituted geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding agents useful for the treatment of, and/or the amelioration of symptoms of, cancer and other proliferative tissue disorders.
摘要翻译: 本发明提供19-取代的格尔德霉素衍生物,其药学上可接受的盐和其前体药物,其是可用于治疗和/或改善癌症和其它增殖性组织病症症状的Hsp90结合剂。
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公开(公告)号:US20120022011A1
公开(公告)日:2012-01-26
申请号:US12673996
申请日:2008-08-22
IPC分类号: A61K31/704 , A61P35/00 , A61K31/337 , C07D225/06 , A61K31/395
CPC分类号: C07D225/02 , C07D225/04 , C07D225/06
摘要: The invention provides purified 19-substituted geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding agents that are useful for the treatment and/or the amelioration of symptoms of cancer and other proliferative tissue disorders.
摘要翻译: 本发明提供了纯化的19-取代的格尔德霉素衍生物,其药学上可接受的盐和其前体药物,其是可用于治疗和/或改善癌症和其它增殖性组织疾病症状的Hsp90结合剂。
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公开(公告)号:US07608611B2
公开(公告)日:2009-10-27
申请号:US11218320
申请日:2005-08-31
申请人: David Ross , David Siegel , Philip Reigan , Wenchang Guo , Daniel L. Gustafson
发明人: David Ross , David Siegel , Philip Reigan , Wenchang Guo , Daniel L. Gustafson
IPC分类号: A01N43/00 , A61K31/33 , C07D225/00 , C07D295/00
CPC分类号: C07D225/02 , C07D225/06 , C07H17/02 , C07H19/00
摘要: The invention provides purified 18,21-didehydro-18,21-dideoxo-18,21-dihydroxy-geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding agents that are useful for the treatment and/or the amelioration of symptoms of cancer and other proliferative tissue disorders.
摘要翻译: 本发明提供了纯化的18,21-二脱氢-18,21-二脱氧-18,21-二羟基 - 格尔德霉素衍生物,其药学上可接受的盐和其前体药物,其是有效的Hsp90结合剂,其可用于治疗和/或改善 癌症和其他增生性组织疾病的症状。
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公开(公告)号:US20090227652A1
公开(公告)日:2009-09-10
申请号:US11908395
申请日:2006-02-27
申请人: David Ross , Philip Reigan , David Siegel , Christopher J. Moody , Marie A. Colucci , Donna Dehn
发明人: David Ross , Philip Reigan , David Siegel , Christopher J. Moody , Marie A. Colucci , Donna Dehn
IPC分类号: A61K31/404 , C07D209/12 , C12N5/06 , A61P35/00
CPC分类号: C07D209/12
摘要: The invention provides indole-4,7-dione derivatives useful for the treatment of diseases in a mammal, pharmaceutical compositions containing the same and methods of using the same in the treatment of cancer and neoplastic diseases including human solid tumors and other mammalian tumors.
摘要翻译: 本发明提供了可用于治疗哺乳动物疾病的吲哚-4,7-二酮衍生物,含有该吲哚-4,7-二酮衍生物的药物组合物及其用于治疗包括人类实体瘤和其它哺乳动物肿瘤在内的癌症和肿瘤疾病的方法。
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公开(公告)号:US20060205705A1
公开(公告)日:2006-09-14
申请号:US11218320
申请日:2005-08-31
申请人: David Ross , David Siegel , Philip Reigan , Wenchang Guo , Daniel Gustafson
发明人: David Ross , David Siegel , Philip Reigan , Wenchang Guo , Daniel Gustafson
IPC分类号: C07D225/04 , A61K31/33 , A61K31/7052 , C07H19/00 , C07H17/02
CPC分类号: C07D225/02 , C07D225/06 , C07H17/02 , C07H19/00
摘要: The invention provides purified 18,21-didehydro-18,21-dideoxo-18,21-dihydroxy-geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding agents that are useful for the treatment and/or the amelioration of symptoms of cancer and other proliferative tissue disorders.
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公开(公告)号:US10214487B2
公开(公告)日:2019-02-26
申请号:US11908395
申请日:2006-02-27
申请人: David Ross , Philip Reigan , David Siegel , Christopher J. Moody , Marie A. Colucci , Donna Dehn
发明人: David Ross , Philip Reigan , David Siegel , Christopher J. Moody , Marie A. Colucci , Donna Dehn
IPC分类号: C07D209/12 , A61K31/404
摘要: The invention provides indole-4,7-dione derivatives useful for the treatment of diseases in a mammal, pharmaceutical compositions containing the same and methods of using the same in the treatment of cancer and neoplastic diseases including human solid tumors and other mammalian tumors.
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公开(公告)号:US20200261290A1
公开(公告)日:2020-08-20
申请号:US15947099
申请日:2018-04-06
申请人: David Ross , Rositsa Stoykova
发明人: David Ross , Rositsa Stoykova
摘要: Embodiments are described for a articulating bed frame which may be utilized as a bed, a chair, or a lift chair. The articulating bed frame has a support frame with a mattress resting thereon. A plurality of support members is in operative communication with at least one motor. A controller allows the user to select from a plurality of configurations and thus modulate the orientation of the bed.
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公开(公告)号:US20140189866A1
公开(公告)日:2014-07-03
申请号:US13969879
申请日:2013-08-19
申请人: Jason Shiffer , David Ross
发明人: Jason Shiffer , David Ross
IPC分类号: G06F21/56
CPC分类号: G06F21/562 , G06F21/55 , G06F21/561 , G06F21/566
摘要: A method to identify character strings associated with potentially malicious software items. The method includes employing a visual algorithm to translate one or more characters of a character string into corresponding characters in a visual ID for use in grouping and comparing computer items having similar visual IDs, such as a reference ID for a computer item that is known to be non-malicious. The method may, among other things, elucidate an attacker's attempt to obfuscate malicious software by using file names that are very similar to those used for harmless files.
摘要翻译: 识别与潜在恶意软件项目相关联的字符串的方法。 该方法包括使用视觉算法将一个或多个字符串的字符转换成视觉ID中的相应字符,以用于分组和比较具有类似视觉ID的计算机项目,例如已知的计算机项目的参考ID 是非恶意的 该方法可以通过使用与用于无害文件的文件名非常相似的文件名来阐明攻击者试图混淆恶意软件的尝试。
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公开(公告)号:US20140181131A1
公开(公告)日:2014-06-26
申请号:US14034672
申请日:2013-09-24
申请人: David Ross
发明人: David Ross
IPC分类号: G06F17/30
CPC分类号: G06F17/30905
摘要: A method for organizing event data by identifying a primary timeline containing event data, extracting a first timestamp from a first item of the primary timeline, setting a radius around the first timestamp, identifying a second timestamp within the radius, determining whether the second timestamp is already in a wrinkle timeline, and, if not, incorporating the second timestamp into the wrinkle timeline. Event data associated with the first item may be marked and emphasized in the wrinkle timeline. The system may also create one or more indexes of the event data.
摘要翻译: 一种用于通过识别包含事件数据的主时间轴来组织事件数据的方法,从主时间线的第一项中提取第一时间戳,设置围绕第一时间戳的半径,识别半径内的第二时间戳,确定第二时间戳是否是 已经处于皱纹时间线,如果没有,将第二个时间戳记并入皱纹时间轴。 可以在皱纹时间线中标记并强调与第一项相关联的事件数据。 系统还可以创建事件数据的一个或多个索引。
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