专利检索 ap:("De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport") AND inv:"Leonardus Aldolfus van der Pol" 第 1 页

1.

发明授权
Process for producing outer membrane vesicles 有权

公开(公告)号：US11542467B2

公开(公告)日：2023-01-03

申请号：US16768919

申请日：2018-12-04

申请人： De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport

发明人： Matthias Joannes Hendrikus Gerritzen , Leonardus Aldolfus van der Pol , Michiel Stork

IPC分类号： C12N1/20 , A61K39/02 , A61K39/09 , A61K39/108 , A61K39/00

摘要： The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process wherein the spontaneous release of bacterial outer membrane vesicles (OMV) of Gram-negative bacteria is stimulated by application of a dissolved oxygen tension (DOT) that is higher than a physiological DOT. The thus produced OMVs are for use in vaccines. The invention further relates to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.