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公开(公告)号:US4385046A
公开(公告)日:1983-05-24
申请号:US216685
申请日:1980-12-15
IPC分类号: A61K51/00 , A61B6/00 , A61K51/06 , C08B37/02 , C08B37/10 , A61K49/00 , A61K43/00 , C08B37/08
CPC分类号: C08B37/0075 , A61K51/065 , A61K2123/00
摘要: A novel class of chelated radio-labeled polysaccharide derivatives are useful for diagnosing formed, and forming, blood clots in a vascular system. Novel intermediate metal-binding compounds comprise a water-soluble polysaccharide moiety having an average of at least 0.25 anionic groups per monosaccharide unit, and at least one chelating group derived from amino acids, substituted cyclic acid anhydrides, or carbon disulfide. The intermediate compound is then reacted with a radioactive tracer metal compound.
摘要翻译: 一类新型的螯合放射性标记多糖衍生物可用于诊断血管系统中形成和形成血块。 新的中间体金属结合化合物包含每个单糖单元平均具有至少0.25个阴离子基团的水溶性多糖部分和至少一种衍生自氨基酸的螯合基团,取代的环状酸酐或二硫化碳。 然后使中间体化合物与放射性示踪剂金属化合物反应。
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公开(公告)号:US4438261A
公开(公告)日:1984-03-20
申请号:US384032
申请日:1982-06-01
申请人: William E. Barnett
发明人: William E. Barnett
IPC分类号: A61K35/14 , C08B37/10 , A61K31/725
CPC分类号: A61K31/715 , C08B37/0075
摘要: Partially depolymerized heparin products having particular analyzable reducing end groups, a process for their preparation and their use as anticoagulants and antithrombotics.
摘要翻译: 具有特定可分析的还原端基的部分解聚的肝素产品,其制备方法及其作为抗凝血剂和抗血栓药物的用途。
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公开(公告)号:US4351938A
公开(公告)日:1982-09-28
申请号:US151163
申请日:1980-05-19
申请人: William E. Barnett
发明人: William E. Barnett
IPC分类号: C08B1/00 , A61K31/715 , A61K35/14 , C08B37/10 , A61K31/725
CPC分类号: A61K31/715 , C08B37/0075
摘要: Partially depolymerized heparin products having particular analyzable reducing end groups, a process for their preparation and their use as anticoagulants and antithrombotics.
摘要翻译: 具有特定可分析的还原端基的部分解聚的肝素产品,其制备方法及其作为抗凝血剂和抗血栓药物的用途。
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