公开(公告)号：US20110224217A1

公开(公告)日：2011-09-15

申请号：US13113135

申请日：2011-05-23

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Steven Spencer Clareen ,  Kimberly Lyn Schwarz ,  Jason Simon Parnes ,  Jennifer R. Riggs ,  Patrick William Papa ,  Sayee Gajanan Hegde ,  Jeffrey Mark McKenna

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Steven Spencer Clareen ,  Kimberly Lyn Schwarz ,  Jason Simon Parnes ,  Jennifer R. Riggs ,  Patrick William Papa ,  Sayee Gajanan Hegde ,  Jeffrey Mark McKenna

IPC分类号： A61K31/519 ,  C12N9/99 ,  A61K31/522 ,  A61P35/00 ,  A61P29/00 ,  A61P37/02 ,  A61P3/00 ,  A61P17/06 ,  A61P11/06 ,  A61P11/02 ,  A61P11/08 ,  A61P11/00 ,  A61P3/04 ,  A61P3/10 ,  A61P1/00 ,  A61P25/28 ,  A61P19/02

CPC分类号： C07D473/00 ,  C07D473/28 ,  C07D473/32 ,  C07D475/00

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供了具有以下结构的杂芳基化合物：其中R 1，R 3，R 4，L，X，Y，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症， ，免疫条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US08383634B2

公开(公告)日：2013-02-26

申请号：US13113135

申请日：2011-05-23

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Steven Spencer Clareen ,  Kimberly Lyn Schwarz ,  Jason Simon Parnes ,  Jennifer R. Riggs ,  Patrick William Papa ,  Sayee Gajanan Hegde ,  Jeffrey Mark McKenna

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Steven Spencer Clareen ,  Kimberly Lyn Schwarz ,  Jason Simon Parnes ,  Jennifer R. Riggs ,  Patrick William Papa ,  Sayee Gajanan Hegde ,  Jeffrey Mark McKenna

IPC分类号： A61P11/06 ,  A61P3/10 ,  A61P31/04 ,  C07D473/28 ,  C07D473/18 ,  C07D519/00 ,  C07D487/04 ,  A61K31/522

CPC分类号： C07D473/00 ,  C07D473/28 ,  C07D473/32 ,  C07D475/00

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供了具有以下结构的杂芳基化合物：其中R 1，R 3，R 4，L，X，Y，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症， ，免疫条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US07968556B2

公开(公告)日：2011-06-28

申请号：US11975657

申请日：2007-10-18

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Steven Spencer Clareen ,  Kimberly Lyn Schwarz ,  Jason Simon Parnes ,  Jennifer R. Riggs ,  Patrick William Papa ,  Sayee Gajanan Hegde ,  Jeffrey Mark McKenna

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Steven Spencer Clareen ,  Kimberly Lyn Schwarz ,  Jason Simon Parnes ,  Jennifer R. Riggs ,  Patrick William Papa ,  Sayee Gajanan Hegde ,  Jeffrey Mark McKenna

IPC分类号： C07D473/28 ,  C07D473/18 ,  C07D519/00 ,  A61K31/522 ,  C07D475/00 ,  C07D487/04 ,  A61P3/10 ,  A61P31/04 ,  A61P11/06

CPC分类号： C07D473/00 ,  C07D473/28 ,  C07D473/32 ,  C07D475/00

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供了具有以下结构的杂芳基化合物：其中R 1，R 3，R 4，L，X，Y，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症， ，免疫条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US20090042890A1

公开(公告)日：2009-02-12

申请号：US11975657

申请日：2007-10-18

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Steven Spencer Clareen ,  Kimberly Lyn Schwarz ,  Jason Simon Parnes ,  Jennifer R. Riggs ,  Patrick William Papa ,  Sayee Gajanan Hegde ,  Jeffrey Mark McKenna

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Steven Spencer Clareen ,  Kimberly Lyn Schwarz ,  Jason Simon Parnes ,  Jennifer R. Riggs ,  Patrick William Papa ,  Sayee Gajanan Hegde ,  Jeffrey Mark McKenna

IPC分类号： A61K31/4985 ,  C07D401/14 ,  C07D473/00 ,  A61P35/00 ,  A61P29/00 ,  C12N5/00 ,  A61P37/00 ,  A61P3/00 ,  C07D475/00 ,  A61K31/52

CPC分类号： C07D473/00 ,  C07D473/28 ,  C07D473/32 ,  C07D475/00

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供了具有以下结构的杂芳基化合物：其中R 1，R 3，R 4，L，X，Y，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症， ，免疫条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US08372976B2

公开(公告)日：2013-02-12

申请号：US13156462

申请日：2011-06-09

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

IPC分类号： C07D487/14

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US07981893B2

公开(公告)日：2011-07-19

申请号：US11975652

申请日：2007-10-18

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

IPC分类号： A61K31/4985

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US20110245245A1

公开(公告)日：2011-10-06

申请号：US13156462

申请日：2011-06-09

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

IPC分类号： A61K31/5377 ,  A61K31/4985 ,  A61P35/02 ,  A61P29/00 ,  A61P37/00 ,  A61P3/00 ,  A61P17/06 ,  A61P37/08 ,  A61P11/08 ,  A61P11/06 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P19/02 ,  A61P25/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US20090023724A1

公开(公告)日：2009-01-22

申请号：US11975652

申请日：2007-10-18

申请人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

发明人： Deborah Sue Mortensen ,  Maria Mercedes Delgado Mederos ,  John Joseph Sapienza ,  Ronald J. Albers ,  Branden G. Lee ,  Roy Leonard Harris, III ,  Graziella Isabel Shevlin ,  Dehua Huang ,  Kimberly Lyn Schwarz ,  Garrick K. Packard ,  Jason Simon Parnes ,  Patrick William Papa ,  Lida Radnia Tehrani ,  Sophie Perrin-Ninkovic ,  Jennifer R. Riggs

IPC分类号： A61K31/4985 ,  A61P35/00 ,  A61P37/00 ,  C07D487/04 ,  A61K31/5377 ,  C07D471/04 ,  A61P3/00 ,  A61P29/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US07521446B2

公开(公告)日：2009-04-21

申请号：US11411413

申请日：2006-04-26

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： C07D473/32 ,  A61K31/52 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。

公开(公告)号：US08101588B2

公开(公告)日：2012-01-24

申请号：US12404413

申请日：2009-03-16

申请人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

发明人： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Sayee G. Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC分类号： C07D473/32 ,  C07F5/02 ,  A61K31/52 ,  A61K31/69 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC分类号： A61K31/52 ,  C07D473/32

摘要： Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。