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1.发明授权公开(公告)号：US08187634B2
公开(公告)日：2012-05-29
申请号：US12377129
申请日：2007-08-31
申请人： Deepak Anant Hegde , Varsha Shashank Choudhary , Venkatasubramanian Radhakrishnan Tarur , Dhananjay Govind Sathe , Harish Kashinath Mondkar , Samadhan Daulat Patil , Sasikumar Mohan Thoovara , Yogesh Sharad Bhide
发明人： Deepak Anant Hegde , Varsha Shashank Choudhary , Venkatasubramanian Radhakrishnan Tarur , Dhananjay Govind Sathe , Harish Kashinath Mondkar , Samadhan Daulat Patil , Sasikumar Mohan Thoovara , Yogesh Sharad Bhide
IPC分类号： A61K31/785 , A61K9/28 , A61P13/12 , C08G61/02
CPC分类号： A61K31/785 , A61K9/284 , A61K9/2846 , A61K9/2866 , C08F8/02 , C08F8/08 , C08F126/02
摘要： Disclosed herein is an improved process for preparation of Sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4 mmol/g. Further, the invention discloses Sevelamer hydrochloride compositions and a novel process for preparation of said compositions comprising high shear non-aqueous granulation.
摘要翻译： 本文公开了一种改进的具有4.7至6.4mmol / g的磷酸盐结合能力的盐酸司维拉姆的制备方法。 此外，本发明公开了盐酸司维拉姆组合物和用于制备包含高剪切非水性造粒物的所述组合物的新方法。
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2.发明申请公开(公告)号：US20100092421A1
公开(公告)日：2010-04-15
申请号：US12620931
申请日：2009-11-18
申请人： Deepak Anant Hegde , Varsha Shashank Choudhary , Venkatasubramanian Radhakrishnan Tarur , Dhananjay Govind Sathe , Harish Kashinath Mondkar , Samadhan Daulat Patil , Sasikumar Mohan Thoovara , Yogesh Sharad Bhide
发明人： Deepak Anant Hegde , Varsha Shashank Choudhary , Venkatasubramanian Radhakrishnan Tarur , Dhananjay Govind Sathe , Harish Kashinath Mondkar , Samadhan Daulat Patil , Sasikumar Mohan Thoovara , Yogesh Sharad Bhide
IPC分类号： A61K31/785 , A61P13/12 , C08G61/02
CPC分类号： A61K31/785 , A61K9/284 , A61K9/2846 , A61K9/2866 , C08F8/02 , C08F8/08 , C08F126/02
摘要： Disclosed herein is an improved process for preparation of Sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4 mmol/g. Further, the invention discloses Sevelamer hydrochloride compositions and a novel process for preparation of said compositions comprising high shear non-aqueous granulation.
摘要翻译： 本文公开了一种改进的具有4.7至6.4mmol / g的磷酸盐结合能力的盐酸司维拉姆的制备方法。 此外，本发明公开了盐酸司维拉姆组合物和用于制备包含高剪切非水性造粒物的所述组合物的新方法。
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3.发明授权公开(公告)号：US07846425B2
公开(公告)日：2010-12-07
申请号：US12620931
申请日：2009-11-18
IPC分类号： A61K31/785 , A61P13/12 , C08G61/02
CPC分类号： A61K31/785 , A61K9/284 , A61K9/2846 , A61K9/2866 , C08F8/02 , C08F8/08 , C08F126/02
摘要： Disclosed herein is an improved process for preparation of Sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4 mmol/g. Further, the invention discloses Sevelamer hydrochloride compositions and a novel process for preparation of said compositions comprising high shear non-aqueous granulation.
摘要翻译： 本文公开了一种改进的具有4.7至6.4mmol / g的磷酸盐结合能力的盐酸司维拉姆的制备方法。 此外，本发明公开了盐酸司维拉姆组合物和用于制备包含高剪切非水性造粒物的所述组合物的新方法。
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4.发明申请NOVEL STABLE PHARMACEUTICAL COMPOSITIONS OF CLOPIDOGREL BISULFATE AND PROCESS OF PREPARATION THEREOF 审中-公开双酚A的新型稳定的药用组合物及其制备方法公开(公告)号：US20100086590A1
公开(公告)日：2010-04-08
申请号：US12575813
申请日：2009-10-08
IPC分类号： A61K9/20 , A61K31/4365 , A61P9/10
CPC分类号： A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2866 , A61K31/4365
摘要： The present invention discloses novel stable oral pharmaceutical compositions comprising the active ingredient Clopidogrel bisulfate and hydrophilic polymers along with pharmaceutically acceptable excipients. Particularly, the said Clopidogrel bisulfate is crystalline Form 1 and the composition additionally comprises of one or more chelating agents and antioxidants. Further the invention relates to a novel process for preparation of stable pharmaceutical compositions wherein the Clopidogrel bisulfate Form I is coated with a hydrophilic polymer thereby providing an increased physical and chemical stability to the composition.
摘要翻译： 本发明公开了包含活性成分氯吡格雷硫酸氢盐和亲水性聚合物以及药学上可接受的赋形剂的新的稳定的口服药物组合物。 特别地，所述氯吡格雷硫酸氢盐是结晶形式1，组合物另外包含一种或多种螯合剂和抗氧化剂。 此外，本发明涉及制备稳定药物组合物的新方法，其中硫酸氢氯吡格雷形式I用亲水性聚合物涂覆，从而为组合物提供增加的物理和化学稳定性。
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