Process for the preparation of colesevelam hydrochloride
    4.
    发明授权
    Process for the preparation of colesevelam hydrochloride 有权
    盐酸利塞维兰的制备方法

    公开(公告)号:US09475891B2

    公开(公告)日:2016-10-25

    申请号:US14490415

    申请日:2014-09-18

    申请人: Mahendra R. Patel

    发明人: Mahendra R. Patel

    CPC分类号: C08F8/02 C08F226/02

    摘要: A novel process of manufacturing colesevelam hydrochloride including the steps of alkylating polyallylamine with n-decylbromide and 6-bromohexyl trimethyl ammonium bromide, followed by cross-linking the alkylated polyallylamine with epichlorohydrin in an aqueous medium, and adding a suitable chloride ion source to obtain colesevelam hydrochloride.

    摘要翻译: 一种制造盐酸利培氟铵的新方法,包括使用正癸基溴和6-溴己基三甲基溴化铵烷基化聚烯丙基胺,然后在水性介质中交联烷基化的聚烯丙基胺与表氯醇,并加入合适的氯离子源以获得大肠杆菌 盐酸盐。

    Thiol-ene cured oil-resistant polyacrylate sealants for in-place gasketing applications
    6.
    发明授权
    Thiol-ene cured oil-resistant polyacrylate sealants for in-place gasketing applications 有权
    硫辛烯固化耐油聚丙烯酸酯密封胶,适用于就地垫片应用

    公开(公告)号:US09243083B2

    公开(公告)日:2016-01-26

    申请号:US12062090

    申请日:2008-04-03

    摘要: The present invention relates to thiol-ene curing compositions, which cure upon exposure to ultraviolet (UV) light and/or heat. The compositions include components having alkenyl (or “ene”) functionality and components having thiol functionality, which undergo thiol-ene curing. The compositions also include a cure system. More specifically, in some embodiments, the curable compositions include a vinyl polymer bearing alkenyl or thiol terminal functional group(s) and a cross-linking agent having the opposing functionality, i.e., thiol cross-linking agents with alkenyl-terminated vinyl polymers and vinyl cross-linking agents with thiol-terminated vinyl polymers. Also provided are methods of making and using the compositions, such as for sealants for in-place gasketing applications.

    摘要翻译: 本发明涉及硫醇烯固化组合物,其在暴露于紫外线(UV)光和/或热时固化。 组合物包括具有烯基(或“烯”)官能团的组分和具有硫醇官能团的组分,其经历硫醇烯固化。 组合物还包括固化体系。 更具体地,在一些实施方案中,可固化组合物包括带有烯基或硫醇末端官能团的乙烯基聚合物和具有相反官能团的交联剂,即具有链烯基封端的乙烯基聚合物和乙烯基的硫醇交联剂 交联剂与硫醇封端的乙烯基聚合物。 还提供了制备和使用组合物的方法,例如用于就地垫片应用的密封剂。