公开(公告)号：US07531318B2

公开(公告)日：2009-05-12

申请号：US11209199

申请日：2005-08-22

申请人： Deepak Srivastava ,  Ildiko Bock-Marquette ,  Ankur Saxena

发明人： Deepak Srivastava ,  Ildiko Bock-Marquette ,  Ankur Saxena

IPC分类号： C12Q1/02

CPC分类号： G01N33/5023 ,  C12Q1/485

摘要： Integrin-linked kinase (ILK) and Akt/protein kinase B (PKB) are important mediators of signaling in cardiomyocytes and can both prevent damage and promote healing associated with ischemic injury to the heart. Thus, the present invention provides for methods of screening for agents that increase the expression of ILK and/or Akt/PKB. Methods of treatment based on such agents are also provided.

摘要翻译： 整合素连接激酶（ILK）和Akt /蛋白激酶B（PKB）是心肌细胞信号传导的重要介质，既可预防损伤，又能促进与心脏缺血性损伤相关的愈合。 因此，本发明提供了筛选增加ILK和/或Akt / PKB表达的试剂的方法。 还提供了基于这些试剂的治疗方法。

公开(公告)号：US20090214507A1

公开(公告)日：2009-08-27

申请号：US11660376

申请日：2005-08-19

申请人： Deepak Srivastava ,  Ildiko Bock-Marquette ,  Ankor Saxena ,  Allan L. Goldstein

发明人： Deepak Srivastava ,  Ildiko Bock-Marquette ,  Ankor Saxena ,  Allan L. Goldstein

IPC分类号： A61K38/45 ,  C12Q1/00 ,  A61K38/28 ,  A61K38/16 ,  A61K38/08

CPC分类号： A61K38/2292 ,  A61K38/00 ,  A61K2300/00

摘要： A method of treatment for treating, preventing, inhibiting or reducing damage to coronary tissue includes inducing at least one of a physiological function selected from: up-regulation of or increasing ILK activity in the coronary tissue, up-regulation of or increasing Akt activity in the coronary tissue, down-regulation of or reducing cardiomyocyte cell death in the coronary tissue and hibernation of cardiomyocytes in the coronary tissue. An induction agent capable of inducing such physiological function in a subject is administered to a subject in need of such treatment.

摘要翻译： 用于治疗，预防，抑制或降低对冠状动脉组织损伤的治疗方法包括诱导下列生理功能中的至少一种：选自以下的生理功能：冠状组织的上调或增加ILK活性，上调Akt活性或增加Akt活性 冠状组织，冠状组织中心肌细胞死亡或冠状动脉组织心肌细胞的下调或减少。 将能够在受试者中诱导这种生理功能的诱导剂施用于需要这种治疗的受试者。