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1.发明授权Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them 失效喜树碱的类似物，它们作为药物的用途以及含有他们的药物组合物公开(公告)号：US07053102B2
公开(公告)日：2006-05-30
申请号：US10862245
申请日：2004-06-07
申请人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
发明人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
IPC分类号： A61K31/47
CPC分类号： C07D213/64 , C07D213/61 , C07D471/14 , C07D491/04
摘要： Compositions for treating cancer comprising an amount of a camptothecin with a 7-ring β-hydroxy lactone ring of the formula wherein the substituents are defined as in the specification sufficient to treat cancer.
摘要翻译： 用于治疗癌症的组合物，其包含一定量的具有下式的7-环β-羟基内酯环的喜树碱，其中取代基如本说明书中所定义，足以治疗癌症。
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2.发明授权Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them 失效喜树碱的类似物，它们作为药物的用途和含有他们的药物组合物公开(公告)号：US06797715B1
公开(公告)日：2004-09-28
申请号：US09612382
申请日：2000-07-07
申请人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
发明人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
IPC分类号： A61K314375
CPC分类号： C07D213/64 , C07D213/61 , C07D471/14 , C07D491/04
摘要： A method of treating a cancer in warm-blooded animals by administration to the warm-blooded animals in need thereof a camptothecin analog a 7-ring member &bgr;-hydroxy lactone ring of the formula wherein the substituents are defined as in the specification.
摘要翻译： 通过给予需要的温血动物治疗温血动物中的癌症的方法如在说明书中所定义的，所述取代基中的喜树碱类似物，7-环成员β-羟基内酯环。
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3.发明授权Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues 失效对羟基喜树碱类似物，其制备方法，作为药物的用途，以及含有所述类似物的药物组合物公开(公告)号：US06339091B1
公开(公告)日：2002-01-15
申请号：US09332520
申请日：1999-06-14
申请人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
发明人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
IPC分类号： C07D49114
CPC分类号： C07D213/64 , C07D213/61 , C07D471/14 , C07D491/04
摘要： The compound of the formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable salts which are useful for the treatment of viral infections, parasitic diseases and the treatment of cancer.
摘要翻译： 取代基中的取代基的化合物如说明书及其无毒的药学上可接受的盐定义，其可用于治疗病毒感染，寄生虫病和癌症治疗。
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4.发明授权Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them 失效喜树碱的类似物，它们作为药物的用途以及含有他们的药物组合物公开(公告)号：US06762301B2
公开(公告)日：2004-07-13
申请号：US10061049
申请日：2002-01-30
申请人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
发明人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
IPC分类号： C07D49122
CPC分类号： C07D213/64 , C07D213/61 , C07D471/14 , C07D491/04
摘要： A process for the preparation of a compound of the formula wherein the substituents are defined as set forth in the specification comprising reacting a compound of the formula with a 2-halo-3-quinoline-methanol of the formula to obtain a compound of the formula which is then cyclized to form the compound of Formula I.
摘要翻译： 制备取代基中的肟基的化合物的方法定义如说明书所述，其包括使制备的2-卤代-3-喹啉 - 甲醇的化合物与制备的化合物反应，得到所需的化合物，然后将其环化 形成式Ⅰ化合物。
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5.发明授权Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them 失效喜树碱的类似物，它们作为药物的用途以及含有他们的药物组合物公开(公告)号：US06815546B2
公开(公告)日：2004-11-09
申请号：US10071046
申请日：2002-02-06
申请人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gérard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
发明人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gérard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
IPC分类号： C07D49114
CPC分类号： C07D213/64 , C07D213/61 , C07D471/14 , C07D491/04
摘要： A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.
摘要翻译： 在该说明书中定义了取代基中的取代基的化合物，其中该化合物可用于治疗癌症。
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6.发明授权Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them 有权喜树碱的类似物，它们作为药物的用途和含有他们的药物组合物公开(公告)号：US07135478B2
公开(公告)日：2006-11-14
申请号：US10930622
申请日：2004-08-31
申请人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gérard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
发明人： Dennis Bigg , Olivier Lavergne , Francesc Pla Rodas , Jacques Pommier , Gérard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
IPC分类号： C07D471/00 , A61K31/44
CPC分类号： C07D213/64 , C07D213/61 , C07D471/14 , C07D491/04
摘要： A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.
摘要翻译： 下式的化合物，其中取代基如本说明书中所定义，其中该化合物可用于治疗癌症。
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7.发明申请New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them 有权喜树碱的新类似物，它们作为药物的用途和含有他们的药物组合物公开(公告)号：US20050038064A1
公开(公告)日：2005-02-17
申请号：US10930622
申请日：2004-08-31
申请人： Dennis Bigg , Olivier Lavergne , Francesc Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
发明人： Dennis Bigg , Olivier Lavergne , Francesc Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
IPC分类号： C07D213/61 , C07D213/64 , C07D471/14 , C07D491/04 , C07D491/22 , C07D498/22
CPC分类号： C07D213/64 , C07D213/61 , C07D471/14 , C07D491/04
摘要： A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.
摘要翻译： 下式的化合物，其中取代基如本说明书中所定义，其中该化合物可用于治疗癌症。
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8.发明授权2-aminopyridine derivatives, their use as medicines and pharmaceutical compositions containing them 失效2-氨基吡啶衍生物，它们作为药物和含有它们的药物组合物的用途公开(公告)号：US06762176B1
公开(公告)日：2004-07-13
申请号：US09743043
申请日：2001-03-08
申请人： Pierre-Etienne Chabrier de Lassauniere , Serge Auvin , Jerry Harnett , Dominique Pons , Gérard Ulibarri , Dennis Bigg
发明人： Pierre-Etienne Chabrier de Lassauniere , Serge Auvin , Jerry Harnett , Dominique Pons , Gérard Ulibarri , Dennis Bigg
IPC分类号： A61K3133
CPC分类号： C07K14/70575 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0368 , A01K2267/0381 , A61K2039/505 , C07D213/73 , C07D401/04 , C07D405/12 , C07K16/2875 , C07K16/2878 , C12N15/8509
摘要： The invention concerns novel 2-aminopyridine derivatives having an activity inhibiting NO-synthase enzymes producing nitrogen monoxide NO and/or trapping reactive forms of oxygen, the methods for preparing them, pharmaceutical compositions containing them and their therapeutic uses, particularly their use as NO-synthase inhibitors and for trapping reactive forms of oxygen whether selectively or not.
摘要翻译： 本发明涉及具有抑制产生一氧化氮NO和/或捕获反应性形式的氧的NO合成酶的活性的新型2-氨基吡啶衍生物，其制备方法，含有它们的药物组合物及其治疗用途，特别是其作为NO- 合成酶抑制剂和用于捕获反应性形式的氧，无论是否有选择性。
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9.发明授权Derivatives of 2-aminopyridines, their use as medicaments and pharmaceutical compositions containing them 失效2-氨基吡啶的衍生物，它们用作药物和含有它们的药物组合物公开(公告)号：US06727239B1
公开(公告)日：2004-04-27
申请号：US10405828
申请日：2003-04-02
申请人： Pierre-Etienne Chabrier de Lassauniere , Serge Auvin , Jerry Harnett , Dominique Pons , Gérard Ulibarri , Dennis Bigg
发明人： Pierre-Etienne Chabrier de Lassauniere , Serge Auvin , Jerry Harnett , Dominique Pons , Gérard Ulibarri , Dennis Bigg
IPC分类号： A61K3133
CPC分类号： C07K14/70575 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0368 , A01K2267/0381 , A61K2039/505 , C07D213/73 , C07D401/04 , C07D405/12 , C07K16/2875 , C07K16/2878 , C12N15/8509
摘要： A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.
摘要翻译： 取代基中的取代基的化合物如说明书中所定义，并且其药学上可接受的盐具有NOS和ROS活性。
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