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    Method and system for holding the position of a guiding member
    1.
    发明授权
    Method and system for holding the position of a guiding member 失效
    用于保持引导构件的位置的方法和系统

    公开(公告)号：US5558101A

    公开(公告)日：1996-09-24

    申请号：US324010

    申请日：1994-10-14

    申请人： Dennis L. Brooks ,  Alfredo G. Bayot ,  Mina W. B. Chow ,  Paul F. Muller

    发明人： Dennis L. Brooks ,  Alfredo G. Bayot ,  Mina W. B. Chow ,  Paul F. Muller

    IPC分类号： A61M25/00 ,  A61M25/06 ,  A61M29/02 ,  A61B5/00

    CPC分类号： A61M25/09 ,  A61M25/0662 ,  A61M2029/025 ,  A61M25/0041

    摘要： A method and system for maintaining the position of a guiding member, such as a guidewire, within a patient's vascular system, particularly within a guiding catheter disposed within the patient's vascular system, while an intravascular catheter slidably mounted on the guiding member is withdrawn and a replacement catheter is advanced over the guiding member. One presently preferred embodiment includes a guiding sheath having an inner lumen extending the length thereof with an engaging device slidably disposed with the guiding sheath. The guidewire engaging device is torqued from its proximal end which extends out of the proximal end of the guiding catheter so that the flexible distal end wraps around the guidewire tightly enough to maintain the position of the guidewire while withdrawing or advancing a catheter over the guidewire. The distal portion of the guidewire engaging device is preferably a pseudo elastic NiTi alloy which is in a stable austenite phase at body temperature (37.degree. C.) and which exhibits a stress-induced transformation from the austenite phase to a martensite phase.

    摘要翻译： 一种方法和系统，用于在患者的血管系统内，特别是在设置在患者的血管系统内的引导导管内，保持引导构件（例如导丝）的位置，同时可滑动地安装在引导构件上的血管内导管被撤回， 置换导管在引导构件上前进。 一个目前优选的实施例包括引导护套，其具有使其长度延伸的内腔和可滑动地布置有引导护套的接合装置。 导线接合装置从其近端扭转，该近端延伸出导引导管的近端，使得柔性远端围绕导丝线紧密地卷绕，以便在将导管拉出或推进导丝线的同时保持导丝的位置。 导丝接合装置的前端部优选为假体弹性NiTi合金，其在体温（37℃）下处于稳定的奥氏体相，并且表现出从奥氏体相到马氏体相的应力诱导相变。

    Method and system for holding the position of a guiding member
    2.
    发明授权
    Method and system for holding the position of a guiding member 失效
    用于保持引导构件的位置的方法和系统

    公开(公告)号：US5749370A

    公开(公告)日：1998-05-12

    申请号：US483478

    申请日：1995-06-07

    申请人： Dennis L. Brooks ,  Alfredo G. Bayot ,  Mina W. B. Chow ,  Paul F. Muller

    发明人： Dennis L. Brooks ,  Alfredo G. Bayot ,  Mina W. B. Chow ,  Paul F. Muller

    IPC分类号： A61M25/01 ,  A61M25/00 ,  A61M25/06 ,  A61M29/02 ,  A61B5/00

    CPC分类号： A61M25/09 ,  A61M25/0662 ,  A61M2029/025 ,  A61M25/0041

    摘要： A method and system for maintaining the position of a guiding member, such as a guidewire, within a patient's vascular system, particularly within a guiding catheter disposed within the patient's vascular system, while an intravascular catheter slidably mounted on the guiding member is withdrawn and a replacement catheter is advanced over the guiding member. One presently preferred embodiment includes a guiding sheath having an inner lumen extending the length thereof with an engaging device slidably disposed with the guiding sheath. The guidewire engaging device is torqued from its proximal end which extends out of the proximal end of the guiding catheter so that the flexible distal end wraps around the guidewire tightly enough to maintain the position of the guidewire while withdrawing or advancing a catheter over the guidewire. The distal portion of the guidewire engaging device is preferably a pseudoelastic NiTi alloy which is in a stable austenite phase at body temperature (37.degree. C.) and which exhibits a stress-induced transformation from the austenite phase to a martensite phase.

    摘要翻译： 一种方法和系统，用于在患者的血管系统内，特别是在设置在患者的血管系统内的引导导管内，保持引导构件（例如导丝）的位置，同时可滑动地安装在引导构件上的血管内导管被撤回， 置换导管在引导构件上前进。 一个目前优选的实施例包括引导护套，其具有使其长度延伸的内腔和可滑动地布置有引导护套的接合装置。 导线接合装置从其近端扭转，该近端延伸出导引导管的近端，使得柔性远端围绕导丝线紧密地卷绕，以便在将导管拉出或推进导丝线的同时保持导丝的位置。 导丝接合装置的远端部优选为在体温（37℃）下处于稳定的奥氏体相的假弹性NiTi合金，并且表现出从奥氏体相到马氏体相的应力诱导相变。

    Embolic filtering devices
    3.
    发明授权
    Embolic filtering devices 有权
    栓塞过滤装置

    公开(公告)号：US08591540B2

    公开(公告)日：2013-11-26

    申请号：US10675611

    申请日：2003-09-29

    申请人： William J. Boyle ,  John E. Papp ,  Charles R. Peterson ,  Paul F. Muller ,  Donald Schwarten ,  Kathern J. Lind

    发明人： William J. Boyle ,  John E. Papp ,  Charles R. Peterson ,  Paul F. Muller ,  Donald Schwarten ,  Kathern J. Lind

    IPC分类号： A61M29/00

    CPC分类号： A61F2/013 ,  A61F2/97 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

    摘要： An embolic filtering system includes a guide wire, a filter device disposed on the guide wire, a sheath adapted to maintain the filter device in an unexpanded position and a torque device having a lumen for receiving the guide wire and a locking mechanism for locking the torque device to the guide wire. The torque device may include a side port adapted to receive the proximal end of the sheath to allow a portion of the guide wire to shear the sheath from the guide wire through retraction of the sheath through the side port. The torque device may include an extension arm having a distal opening adapted to receive both the guide wire and the sheath. A second lumen may be used to allow a portion of the guide wire to shear the sheath away from the guide wire through retraction of the sheath through the second lumen.

    摘要翻译： 栓塞过滤系统包括引导线，设置在引导线上的过滤器装置，适于将过滤装置保持在未膨胀位置的护套和具有用于容纳引导线的内腔的扭矩装置和用于锁定扭矩的锁定机构 设备到导丝。 扭矩装置可以包括适于容纳护套的近端的侧端口，以允许导线的一部分通过护套通过侧端部缩回而从引导线剪切护套。 扭矩装置可以包括延伸臂，其具有适于接纳导丝和护套的远端开口。 可以使用第二内腔来允许引导线的一部分通过使护套通过第二内腔缩回而将护套从引导线上剪切。

    Expandable cages for embolic filtering devices
    4.
    发明授权
    Expandable cages for embolic filtering devices 有权
    用于栓塞过滤装置的可膨胀笼

    公开(公告)号：US07344549B2

    公开(公告)日：2008-03-18

    申请号：US10066314

    申请日：2002-01-31

    申请人： William J. Boyle ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  John E. Papp

    发明人： William J. Boyle ,  William J. Harrison ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  John E. Papp

    IPC分类号： A61M29/00

    CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/008

    摘要： A self-expanding cage for use in conjunction with an embolic filtering device includes a circumferential member adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. A proximal strut and distal strut are attached to the circumferential member to form the cage. A plurality of proximal and distal struts may be attached the circumferential member. Additionally, a second circumferential member can be attached to the first circumferential member. Each circumferential member can be connected by a single or a plurality of connecting struts. One embodiment of the cage utilizes a single wire to form to the cage. A delivery system attached to the single wire cage moves the cage and its associated filter element between the expanded and unexpanded positions through relative movement of the distal delivery system. This can be accomplished by either torquing the guide wire onto which the expandable cage is mounted or by longitudinally moving a tubular member which forms part of the delivery system longitudinally in relation to the guide wire.

    摘要翻译： 用于与栓塞过滤装置结合使用的自膨胀笼包括适于从未膨胀位置膨胀到患者体内容器内的扩张位置的周向构件。 近端支柱和远侧支柱附接到周向构件以形成保持架。 多个近端和远侧支柱可以附接在周向构件上。 此外，第二周向构件可以附接到第一圆周构件。 每个周向构件可以通过单个或多个连接支柱连接。 笼的一个实施例使用单个线来形成笼。 附接到单线笼的输送系统通过远端输送系统的相对运动使笼及其相关联的过滤元件在膨胀位置和未膨胀位置之间移动。 这可以通过扭转其上安装有可膨胀笼的引导线或通过纵向移动相对于导丝纵向移动形成输送系统的一部分的管状构件来实现。

    Guide wire with damped force vibration mechanism
    6.
    发明授权
    Guide wire with damped force vibration mechanism 有权
    导丝采用阻尼力振动机构

    公开(公告)号：US06290656B1

    公开(公告)日：2001-09-18

    申请号：US09475381

    申请日：1999-12-30

    申请人： William J. Boyle ,  Paul F. Muller

    发明人： William J. Boyle ,  Paul F. Muller

    IPC分类号： A61B500

    CPC分类号： A61M25/09

    摘要： A guide wire having a damped force vibration mechanism which isolates vibrations or shockwaves which otherwise would be transmitted along the length of the guide wire to its distal end. The damped force vibration mechanism helps absorb some of the energy created during the exchange of a delivery catheter or an interventional device on the guide wire or any shock or force generated from an external source. The damped force vibration mechanism absorbs vibrations or shock which would otherwise act on medical devices attached near the distal end of a guide wire. The damped force vibration mechanism may consist of a reduced segment on the guide wire which can be made from a material such as superelastic or plastically deformable, biocompatible materials. The damped force vibration mechanism can have a relatively straight configuration or can have a wave-shaped form, or other shape which helps absorb vibratory motion.

    摘要翻译： 具有阻尼力振动机构的引导线，其隔离振动或冲击波，否则其将沿着导丝的长度传递到其远端。 阻尼力振动机制有助于吸收在导丝或交流导管或介入装置交换导线时产生的一些能量，或从外部源产生的任何冲击或力。 阻尼力振动机构吸收振动或冲击，否则这些振动或冲击将作用在附着在导丝末端附近的医疗装置上。 阻尼力振动机构可以由导丝上的减少的部分组成，其可由诸如超弹性或塑性变形的生物相容性材料的材料制成。 阻尼力振动机构可以具有相对直的构造或者可以具有波形形状或其它有助于吸收振动的形状。

    Systems and methods for modeling product penetration and repeat
    9.
    发明授权
    Systems and methods for modeling product penetration and repeat 失效
    用于建模产品渗透和重复的系统和方法

    公开(公告)号：US07319972B2

    公开(公告)日：2008-01-15

    申请号：US10315744

    申请日：2002-12-10

    申请人： Michael F. von Gonten ,  Paul F. Muller

    发明人： Michael F. von Gonten ,  Paul F. Muller

    IPC分类号： G06Q10/00

    CPC分类号： G06Q30/02 ,  G06Q30/0201 ,  G06Q30/0202

    摘要： Methods, devices and systems are provided for modeling product volume penetration. A system embodiment includes a remote client operably connected to a server, having a number of client files, and an input device. A set of computer executable instructions are operable on the system for projecting product penetration of a product in a client file at a selectable point in time from a product launch or other starting point, based on a set of purchase data for the product. The set of computer executable instructions are operable for receiving the set of purchase data and graphically displaying the set of purchase data as a volume of product sales versus a number of time increments from the starting point. The set of computer executable instructions are further operable for mapping a curvilinear function to the graphically displayed set of purchase data by applying a function expressed as f(t)=s×tB.

    摘要翻译： 提供了用于建模产品体积渗透的方法，设备和系统。 系统实施例包括可操作地连接到服务器的远程客户端，具有多个客户端文件以及输入设备。 一组计算机可执行指令在系统上可操作，用于基于产品的一组购买数据，从产品发布或其他起点在可选择的时间点投射产品在客户端文件中的产品渗透。 一组计算机可执行指令可操作用于接收一组采购数据，并且以图形方式将购买数据集合作为产品销售量相对于起始点的时间增量数量进行图形显示。 计算机可执行指令的集合还可用于通过应用表示为f（t）= sxt 的功能将曲线函数映射到图形显示的购买数据集合。

    Vessel occlusion device for embolic protection system
    10.
    发明授权
    Vessel occlusion device for embolic protection system 有权

    公开(公告)号：US07048758B2

    公开(公告)日：2006-05-23

    申请号：US10457073

    申请日：2003-06-06

    申请人： William J. Boyle ,  Andy E. Denison ,  Paul F. Muller

    发明人： William J. Boyle ,  Andy E. Denison ,  Paul F. Muller

    IPC分类号： A61M29/00

    CPC分类号： A61B17/12172 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/22067 ,  A61F2/013 ,  A61F2/95 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008 ,  A61F2230/0093

    摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of capturing embolic material which may be released into a blood vessel during a therapeutic interventional procedure at the site of a lesion in the blood vessel. The system is adapted to be utilized in a collateral blood supply system adapted to enable the flow of blood to bypass the blood vessel upon blocking thereof and to enable the reverse flow of blood through the blood vessel upon unblocking thereof. The system includes a guide wire, including a distal end, adapted to be positioned in a blood vessel relative to an interventional procedure site. A guide catheter, including a distal end, is adapted to enable the interventional procedure to be performed, and to be inserted over the guide wire and through a patient's vasculature to a position in the blood vessel relative to the interventional procedure site. An occluding device for occluding and blocking a blood vessel at a location relative to the interventional procedure site is adapted to be positionable at a location relative to he interventional procedure site, to be expandable so as to prevent and block the flow of blood past the occlusion, and to enable the capture of embolic material which may be released into the blood in the blood vessel during the therapeutic interventional procedure, and to be contracted to unblock the blood vessel and enable the recovery of captured embolic material.