公开(公告)号：US07048758B2

公开(公告)日：2006-05-23

申请号：US10457073

申请日：2003-06-06

申请人： William J. Boyle ,  Andy E. Denison ,  Paul F. Muller

发明人： William J. Boyle ,  Andy E. Denison ,  Paul F. Muller

IPC分类号： A61M29/00

CPC分类号： A61B17/12172 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/22067 ,  A61F2/013 ,  A61F2/95 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008 ,  A61F2230/0093

摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of capturing embolic material which may be released into a blood vessel during a therapeutic interventional procedure at the site of a lesion in the blood vessel. The system is adapted to be utilized in a collateral blood supply system adapted to enable the flow of blood to bypass the blood vessel upon blocking thereof and to enable the reverse flow of blood through the blood vessel upon unblocking thereof. The system includes a guide wire, including a distal end, adapted to be positioned in a blood vessel relative to an interventional procedure site. A guide catheter, including a distal end, is adapted to enable the interventional procedure to be performed, and to be inserted over the guide wire and through a patient's vasculature to a position in the blood vessel relative to the interventional procedure site. An occluding device for occluding and blocking a blood vessel at a location relative to the interventional procedure site is adapted to be positionable at a location relative to he interventional procedure site, to be expandable so as to prevent and block the flow of blood past the occlusion, and to enable the capture of embolic material which may be released into the blood in the blood vessel during the therapeutic interventional procedure, and to be contracted to unblock the blood vessel and enable the recovery of captured embolic material.

公开(公告)号：US06702834B1

公开(公告)日：2004-03-09

申请号：US09727102

申请日：2000-11-28

申请人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

发明人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

公开(公告)号：US07217255B2

公开(公告)日：2007-05-15

申请号：US10386071

申请日：2003-03-10

申请人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Richard S. Stack ,  Kent C. B. Stalker ,  Christopher Tarapata ,  John D. Whitfield

发明人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Richard S. Stack ,  Kent C. B. Stalker ,  Christopher Tarapata ,  John D. Whitfield

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

公开(公告)号：US06540722B1

公开(公告)日：2003-04-01

申请号：US09490319

申请日：2000-01-24

申请人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Richard S. Stack ,  Kent C. B. Stalker ,  Christopher Tarapata ,  John D. Whitfield

发明人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Richard S. Stack ,  Kent C. B. Stalker ,  Christopher Tarapata ,  John D. Whitfield

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

公开(公告)号：US20100174355A1

公开(公告)日：2010-07-08

申请号：US12724140

申请日：2010-03-15

申请人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C.B. Stalker

发明人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C.B. Stalker

IPC分类号： A61F2/84

CPC分类号： A61F2/013 ,  A61F2/95 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.

摘要翻译： 部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。 部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。 用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。 在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。 恢复护套可以在内导管上推进以使可膨胀过滤器折叠。 内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。

公开(公告)号：US06929652B1

公开(公告)日：2005-08-16

申请号：US09872692

申请日：2001-06-01

申请人： Christopher C. Andrews ,  William J. Boyle ,  Sergio Correa ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Brad Jordan ,  Paul Muller ,  Paul V. Neale ,  Samir Patel ,  Richard Stack

发明人： Christopher C. Andrews ,  William J. Boyle ,  Sergio Correa ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Brad Jordan ,  Paul Muller ,  Paul V. Neale ,  Samir Patel ,  Richard Stack

IPC分类号： A61F2/01 ,  A61F2/06 ,  A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A system for enabling the insertion and removal of an embolic protection device, for capturing and retaining embolic debris which may be created during the performance of a therapeutic interventional procedure in a stenosed or occluded region of a blood vessel. The system, in an embodiment thereof, is capable of enabling at least one operator to control the delivery and removal of an embolic protection device to a position in a patient's vasculature distal to an interventional procedure site, to enable the exchange of the delivery and recovery system. The system, in another embodiment thereof, includes a delivery system and a recovery system which are capable of enabling the delivery and recovery of an embolic protection device so as to maintain a clinically acceptable profile and flexibility through the patient's vasculature.

摘要翻译： 一种能够插入和移除栓塞保护装置的系统，用于捕获和保留在血管的狭窄或阻塞区域中执行治疗介入手术期间可产生的栓塞碎片。 该系统在其一个实施例中能够使至少一个操作者能够将栓塞保护装置的输送和移除控制到远离介入手术部位的患者脉管系统中的位置，以实现交付和恢复的交换 系统。 该系统在其另一个实施例中包括输送系统和恢复系统，其能够实现栓塞保护装置的输送和恢复，以便通过患者的脉管系统保持临床可接受的特征和灵活性。

公开(公告)号：US06887258B2

公开(公告)日：2005-05-03

申请号：US10180287

申请日：2002-06-26

申请人： Andy E. Denison ,  William J. Boyle

发明人： Andy E. Denison ,  William J. Boyle

IPC分类号： A61F2/01 ,  A61F2/06 ,  A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2002/065 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/008

摘要： An embolic filtering device for use in a bifurcated vessel includes delivery device having a first guide wire and a second guide wire. The second guide wire diverges from the distal-end region of the first guide wire. The filter device also includes a filter support having a first deployment member and a second deployment member. These deployment members can be formed as a first loop and a second loop. A bifurcated filter element is coupled to the filter support. The distal-end region of the first guide wire extends through a first leg of the filter element and the second guide wire extends through a second leg of the filter element. During use, the first leg of the filter element is deployed within a first branch of the bifurcated vessel and the second leg of the filter element is deployed within a second branch of the bifurcated vessel.

摘要翻译： 用于分叉容器的栓塞过滤装置包括具有第一导丝和第二导丝的输送装置。 第二引导线从第一导丝的远端区域分叉。 过滤装置还包括具有第一展开构件和第二展开构件的过滤器支撑件。 这些展开部件可以形成为第一环和第二环。 分离的过滤元件连接到过滤器支撑件。 第一导丝的远端区域延伸穿过过滤元件的第一腿部，并且第二导丝线延伸穿过过滤元件的第二腿部。 在使用期间，过滤元件的第一腿部分在分叉容器的第一分支内，并且过滤元件的第二腿部分在分叉容器的第二分支内。

公开(公告)号：US06695813B1

公开(公告)日：2004-02-24

申请号：US09476159

申请日：1999-12-30

申请人： William J. Boyle ,  David H. Burkett ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Arkady Kokish ,  Kent C. B. Stalker ,  Chicheng Wang ,  John D. Whitfield

发明人： William J. Boyle ,  David H. Burkett ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Arkady Kokish ,  Kent C. B. Stalker ,  Chicheng Wang ,  John D. Whitfield

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device includes a filtering assembly having a self-expanding strut assembly and a filter element. The filtering assembly can be attached to a guidewire and deployed within the patient's vasculature into an area of treatment. A restraining sheath maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Interventional devices can be delivered over the guidewire and any embolic debris created and released into the blood stream will enter the filtering assembly. The filtering assembly can be rotatably mounted on the guide wire and may include a dampening element which helps to prevent some shock force that may be transmitted along the guide to the deployed filtering assembly.

摘要翻译： 栓塞保护装置包括具有自扩张支柱组件和过滤元件的过滤组件。 过滤组件可以附接到导丝并且部署在患者的脉管系统内进入治疗区域。 限制护套将过滤组件保持在其折叠位置，直到其准备好被医生部署为止。 介入装置可以通过导线传送，并且产生并释放到血流中的任何栓塞碎片将进入过滤组件。 过滤组件可以可旋转地安装在导丝上，并且可以包括阻尼元件，该阻尼元件有助于防止可能沿着引导件传递到部署的过滤组件的一些冲击力。

公开(公告)号：US06582448B1

公开(公告)日：2003-06-24

申请号：US09746790

申请日：2000-12-21

申请人： William J. Boyle ,  Andy E. Denison

发明人： William J. Boyle ,  Andy E. Denison

IPC分类号： A61M2900

CPC分类号： A61B17/12172 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12136 ,  A61B2017/22067 ,  A61F2/013 ,  A61F2/95 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008 ,  A61F2230/0093

摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of capturing embolic material which may be released into a blood vessel during a therapeutic interventional procedure at the site of a lesion in the blood vessel. The system is adapted to be utilized in a collateral blood supply system adapted to enable the flow of blood to bypass the blood vessel upon blocking thereof and to enable the reverse flow of blood through the blood vessel upon unblocking thereof. The system includes a guide wire, including a distal end, adapted to be positioned in a blood vessel relative to an interventional procedure site. A guide catheter, including a distal end, is adapted to enable the interventional procedure to be performed, and to be inserted over the guide wire and through a patient's vasculature to a position in the blood vessel relative to the interventional procedure site. An occluding device for occluding and blocking a blood vessel at a location relative to the interventional procedure site is adapted to be positionable at a location relative to he interventional procedure site, to be expandable so as to prevent and block the flow of blood past the occlusion, and to enable the capture of embolic material which may be released into the blood in the blood vessel during the therapeutic interventional procedure, and to be contracted to unblock the blood vessel and enable the recovery of captured embolic material.

摘要翻译： 在狭窄或闭塞区域进行介入手术时使用的系统，其能够捕获在血液中的病变部位的治疗性介入手术期间可释放到血管中的栓塞物质 船只。 该系统被适用于辅助血液供应系统，其适于使血液流动在其血管阻断时绕过血管，并且能够在解除阻塞时使血液反向流过血管。 该系统包括导线，其包括远端，适于相对于介入手术部位定位在血管中。 包括远端的引导导管适于使得能够执行介入手术，并且相对于介入手术部位将导管插入穿过导线并穿过患者的脉管系统到血管中的位置。 用于在相对于介入手术部位的位置闭塞和阻塞血管的闭塞装置适于可定位于相对于介入手术部位的位置，以可扩张，以便防止和阻止血液流过闭塞 ，并且能够在治疗介入手术期间捕获可能释放到血管中的栓塞物质，并且收缩以解除血管并阻止捕获的栓塞物质的回收。

公开(公告)号：US08672991B2

公开(公告)日：2014-03-18

申请号：US12724140

申请日：2010-03-15

申请人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

发明人： William J. Boyle ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  John E. Papp ,  Charles R. Peterson ,  Kent C. B. Stalker

IPC分类号： A61F2/06

CPC分类号： A61F2/013 ,  A61F2/95 ,  A61F2002/011 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/008

摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.

摘要翻译： 部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。 部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。 用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。 在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。 恢复护套可以在内导管上推进以使可膨胀过滤器折叠。 内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。