公开(公告)号：US20220363319A1

公开(公告)日：2022-11-17

申请号：US17663382

申请日：2022-05-13

申请人： Derek Grant

发明人： Derek Grant ,  Mark Lipsey

IPC分类号： B62D25/18 ,  B62D25/16 ,  B60B7/04

摘要： Apparatus and associated methods relate to a tire containment device securely mounted to an axle of a vehicle to contain shrapnel caused by a tire blowout. In an illustrative example, the tire containment device may include an axle bracket and a tire fender. The axle bracket, for example, may be mounted to an axle of the vehicle. The tire fender may, for example, have a substantially continuous containment cavity. In some examples, when the tire fender is coupled to a vehicle axle by the axle bracket, the containment cavity may extend over at least a top and an exterior face of an upper third of a diameter of a tire. For example, the containment cavity may substantially intercept shrapnel from failure of the tire before it reaches a body of the vehicle. Various embodiments may advantageously reduce damage to a body of the vehicle during a tire blowout.

公开(公告)号：US06310051B1

公开(公告)日：2001-10-30

申请号：US09599861

申请日：2000-06-23

申请人： Jan Olof Gustav Karlsson ,  Rolf Goran Gustav Andersson ,  Anders Olsson ,  Bo Zieden ,  Per Jynge ,  Tudor Griffith ,  Derek Grant ,  Robertson Towart ,  Helge Refsum

发明人： Jan Olof Gustav Karlsson ,  Rolf Goran Gustav Andersson ,  Anders Olsson ,  Bo Zieden ,  Per Jynge ,  Tudor Griffith ,  Derek Grant ,  Robertson Towart ,  Helge Refsum

IPC分类号： A61K31675

CPC分类号： A61K31/444 ,  A61K31/198 ,  A61K31/675 ,  Y02A50/411 ,  Y02A50/414 ,  Y10S514/824

摘要： The invention provides the use of dipyridoxyl or aminopolycarboxylic acid based chelating agents, metal chelates and salts thereof, in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of atherosclerosis and related conditions in the human or non-human animal body. Preferred compounds for use in the method of the invention are compounds of formula (I) or a metal chelate or salt thereof (wherein in formula (I) each R1 independently represents hydrogen or —CH2COR5; R5 represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R2 independently represents a group XYR6; X represents a bond, or a C1-3 alkylene or oxoalkylene group optionally substituted by a group R7; Y represents a bond, an oxygen atom or a group NR6; R6 is a hydrogen atom, a group COOR8, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR8, CONR82, NR82, OR8, ═R8, ═O, OP(O)(OR8)R7 and OSO3M; R7 is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation, e.g. an alkali or alkaline earth cation, an ammonium ion or an organic amine cation, such as a meglumine ion; R3 represents a C1-8 alkylene group, preferably a C1-6, e.g. a C2-4 alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; each R4 independently represents hydrogen or C1-3 alkyl; and each R9 independently may be absent or represents hydrogen, alkyl, hydroxyalkyl or carboxyalkyl).

摘要翻译： 本发明提供了双嘧磺酰氧基或氨基多羧酸类螯合剂，金属螯合物及其盐在制备用于治疗或预防人或非人动物体内的动脉粥样硬化和相关病症的治疗剂中的用途。 用于本发明方法的优选化合物是式（I）化合物或金属螯合物或其盐（其中在式（I）中，每个R 1独立地表示氢或-CH 2 COR 5; R 5表示羟基，任选羟基化的烷氧基，氨基或 烷基酰氨基;每个R 2独立地表示基团XYR 6; X表示键或任选被基团R 7取代的C 1-3亚烷基或氧代亚烷基; Y表示键，氧原子或基团NR 6; R 6是氢原子， 任选被一个或多个选自COOR8，CONR82，NR82，OR8，R8，= O，OP（O）（OR8）R7和OSO3M的基团取代的COOR8，烷基，烯基，环烷基，芳基或芳烷基; R7 羟基，任选羟基化，任选烷氧基化的烷基或氨基烷基; R 8是氢原子或任选羟基化，任选烷氧基化的烷基; M是氢原子或一当量的生理上可耐受的阳离子，例如碱金属或碱土金属阳离子 ，铵io n或有机胺阳离子，如葡甲胺离子; R 3表示C 1-8亚烷基，优选C 1-6。 C2-4亚烷基，1,2-亚环烷基或1,2-亚芳基; 每个R 4独立地表示氢或C 1-3烷基; 并且每个R 9独立地可以不存在或表示氢，烷基，羟基烷基或羧基烷基）。