公开(公告)号：US06498017B2

公开(公告)日：2002-12-24

申请号：US09508959

申请日：2000-05-22

申请人： Detlev Riesner ,  Karin Post ,  Oliver Schaefer ,  Martin Pitschke ,  Manfred Eigen ,  Jan Bieschke

发明人： Detlev Riesner ,  Karin Post ,  Oliver Schaefer ,  Martin Pitschke ,  Manfred Eigen ,  Jan Bieschke

IPC分类号： C12Q137

CPC分类号： G01N33/6896

摘要： A method for the diagnostic detection of diseases associated with protein depositions (pathological protein depositions) by measuring an association of substructures of the pathological protein depositions, structures forming pathological protein depositions, structures corresponding to pathological protein depositions and/or pathological protein depositions as a probe; to substructures of the pathological protein depositions structures forming pathological protein depositions, structures corresponding to pathological protein deposition and/or pathological protein depositions as targets; characterized in that the target is detected in liquid phase wherein, in the case of detecting Alzheimer's disease, the liquid phase is obtained from body fluids or is itself a body fluid; with the proviso that the association of the probe to the target is measured before self-aggregation of the probe predominates.

摘要翻译： 通过测量病理蛋白沉积的亚结构，形成病理蛋白沉积的结构，对应于病理蛋白沉积的结构和/或病理蛋白沉积作为探针来诊断与蛋白质沉积相关的疾病（病理蛋白沉积）的诊断方法 ;形成病理蛋白沉积的病理蛋白沉积结构的亚结构，对应于病理蛋白沉积和/或病理蛋白沉积的靶标的结构;其特征在于在液相中检测靶，其中在检测阿尔茨海默病的情况下， 液相是从体液中获得的，或者本身是体液;条件是在探针的自身聚集占优势之前测量探针与靶标的结合。