公开(公告)号：US20190282691A1

公开(公告)日：2019-09-19

申请号：US16349153

申请日：2017-11-10

申请人： Deutsches Krebsforschungszentrum

发明人： Henri-Jacques Delecluse ,  Anatoliy Shumilov ,  Ming-Han Tsai

IPC分类号： A61K39/245 ,  C12N7/00 ,  A61P31/22

摘要： The present invention relates to a composition comprising Epstein-Barr Virus (EBV) particles for use in vaccination of a subject, wherein said EBV particles comprise a significantly reduced chromosome instability-inducing EBV polypeptide activity. The present invention also relates to a composition comprising EBV particles for use in vaccination of a subject, wherein said vaccination comprises avoiding contacting the cytosol and/or nucleus of cells of said subject with a chromosome instability-inducing EBV polypeptide activity. Moreover, the present invention relates to polynucleotides, host cells, methods, and uses related to the aforesaid compositions.

公开(公告)号：US11097003B2

公开(公告)日：2021-08-24

申请号：US16349153

申请日：2017-11-10

申请人： Deutsches Krebsforschungszentrum

发明人： Henri-Jacques Delecluse ,  Anatoliy Shumilov ,  Ming-Han Tsai

IPC分类号： A61K39/245 ,  A61P31/22 ,  C12N7/00 ,  A61K39/12

摘要： The present invention relates to a composition comprising Epstein-Barr Virus (EBV) particles for use in vaccination of a subject, wherein said EBV particles comprise a significantly reduced chromosome instability-inducing EBV polypeptide activity. The present invention also relates to a composition comprising EBV particles for use in vaccination of a subject, wherein said vaccination comprises avoiding contacting the cytosol and/or nucleus of cells of said subject with a chromosome instability-inducing EBV polypeptide activity. Moreover, the present invention relates to polynucleotides, host cells, methods, and uses related to the aforesaid compositions.