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公开(公告)号：US11638765B2
公开(公告)日：2023-05-02
申请号：US16765927
申请日：2018-11-20
发明人： Matthias Eder , Klaus Kopka , Martin Schaefer , Ulrike Bauder-Wuest , Uwe Haberkorn , Ann-Christin Eder , Jens Cardinale , Martina Benesova
IPC分类号： A61K51/00 , A61M36/14 , A61K51/04 , A61K49/00 , G01N33/574 , G01N33/58 , G01N33/60 , A61K49/10 , C07D403/14 , C09B23/01 , C09B23/08
摘要： The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; x2 is a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.
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公开(公告)号：US11452786B2
公开(公告)日：2022-09-27
申请号：US16763667
申请日：2018-11-12
发明人： Ann-Christin Eder , Matthias Eder , Klaus Kopka , Martin Schaefer , Ulrike Bauder-Wuest , Uwe Haberkorn
IPC分类号： A61K51/04 , C07D403/14
摘要： The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x1-(B)-x2-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer covalently connecting (A) and (B); x2 is a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein R1 to R4, R9, a, b, Y and X1 to X4 have the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.
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公开(公告)号：US10815200B2
公开(公告)日：2020-10-27
申请号：US15915978
申请日：2018-03-08
发明人： Jens Cardinale , Martin Schaefer , Klaus Kopka , Matthias Eder , Ulrike Bauder-Wuest , Michael Eisenhut , Martina Benesova , Uwe Haberkorn , Frederik L. Giesel
IPC分类号： A61K38/00 , C07D213/61 , A61K51/04 , C07B59/00 , G01N33/574 , C07K7/02 , A61P35/00
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.
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公开(公告)号：US12054458B2
公开(公告)日：2024-08-06
申请号：US18186043
申请日：2023-03-17
发明人： Jens Cardinale , Martin Schaefer , Klaus Kopka , Matthias Eder , Ulrike Bauder-Wuest , Michael Eisenhut , Martina Benesova , Uwe Haberkorn , Frederik L. Giesel
IPC分类号： C07D213/61 , A61K38/00 , A61K51/04 , A61P35/00 , C07B59/00 , C07K7/02 , G01N33/574
CPC分类号： C07D213/61 , A61K51/04 , A61K51/0455 , A61P35/00 , C07B59/002 , C07K7/02 , G01N33/57434 , A61K38/00 , C07B2200/05
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.
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5.发明公开公开(公告)号：US20230295092A1
公开(公告)日：2023-09-21
申请号：US18186043
申请日：2023-03-17
发明人： Jens Cardinale , Martin Schaefer , Klaus Kopka , Matthias Eder , Ulrike Bauder-Wuest , Michael Eisenhut , Martina Benesova , Uwe Haberkorn , Frederik L. Giesel
IPC分类号： C07D213/61 , A61K51/04 , C07B59/00 , G01N33/574 , C07K7/02 , A61P35/00
CPC分类号： C07D213/61 , A61K51/0455 , C07B59/002 , G01N33/57434 , A61K51/04 , C07K7/02 , A61P35/00 , A61K38/00
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.
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公开(公告)号：US10398791B2
公开(公告)日：2019-09-03
申请号：US16114988
申请日：2018-08-28
发明人： Matthias Eder , Klaus Kopka , Martin Schäfer , Ulrike Bauder-Wüst , Uwe Haberkorn , Michael Eisenhut , Walter Mier , Martina Benesova
IPC分类号： A61K51/04 , C07B59/00 , C07D295/145 , C07D257/02
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
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公开(公告)号：US11931430B2
公开(公告)日：2024-03-19
申请号：US17110558
申请日：2020-12-03
发明人： Matthias Eder , Klaus Kopka , Martin Schäfer , Ulrike Bauder-Wüst , Michael Eisenhut , Walter Mier , Martina Benesova
IPC分类号： A61K51/04 , C07B59/00 , C07D257/02 , C07D295/145
CPC分类号： A61K51/0482 , A61K51/0402 , A61K51/0497 , C07B59/002 , C07D257/02 , C07D295/145
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
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公开(公告)号：US11045564B2
公开(公告)日：2021-06-29
申请号：US16551198
申请日：2019-08-26
发明人： Matthias Eder , Klaus Kopka , Martin Schäfer , Ulrike Bauder-Wüst , Michael Eisenhut , Walter Mier , Martina Benesova
IPC分类号： A61K51/04 , C07B59/00 , C07D295/145 , C07D257/02
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
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公开(公告)号：US11951190B2
公开(公告)日：2024-04-09
申请号：US17143280
申请日：2021-01-07
发明人： Matthias Eder , Klaus Kopka , Martin Schäfer , Ulrike Bauder-Wüst , Michael Eisenhut , Walter Mier , Martina Benesova
IPC分类号： A61K51/04 , C07B59/00 , C07D257/02 , C07D295/145
CPC分类号： A61K51/0482 , A61K51/0402 , A61K51/0497 , C07B59/002 , C07D257/02 , C07D295/145
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
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公开(公告)号：US10471160B2
公开(公告)日：2019-11-12
申请号：US16038729
申请日：2018-07-18
发明人： Matthias Eder , Klaus Kopka , Martin Schäfer , Ulrike Bauder-Wüst , Uwe Haberkorn , Michael Eisenhut , Walter Mier , Martina Benesova , Hans-Christian Kliem , Clemens Kratochwil
IPC分类号： A61K51/04 , C07D257/02 , C07B59/00 , C07D295/145
摘要： The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).
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