公开(公告)号：US20210388046A1

公开(公告)日：2021-12-16

申请号：US17417112

申请日：2019-12-23

Applicant: Development Center for Biotechnology

Inventor： Chao-Yi TENG ,  Ying-Ju CHEN

IPC: C07K14/47 ,  C07K14/705 ,  C12N9/16 ,  C07K16/00

Abstract: A chimeric signal peptide for protein expression includes an N-region, a hydrophobic region, and a C-region, wherein the N-region and the C-region are from a same signal peptide of a first protein and the hydrophobic region is from a signal peptide of a second protein, wherein the first protein is different from the second protein. The first and second protein are independently selected from the group consisting of BM40, IL2, HA, Insulin, CD33, IFNA2, IgGK leader, AZU, and SEAP.