公开(公告)号：US20210015942A1

公开(公告)日：2021-01-21

申请号：US16244090

申请日：2019-01-09

申请人： Development Center for Biotechnology

发明人： Shih-Hsien Chuang ,  Chu-Bin Liao ,  Wei-Ting Sun ,  Chen-Hsien Liang ,  Wun-Huei Lin ,  Chun-Liang Lai ,  Her-Sheng Lin

IPC分类号： A61K47/68 ,  C07K16/32 ,  A61P35/00

摘要： An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.