公开(公告)号：US20170369525A1

公开(公告)日：2017-12-28

申请号：US15541020

申请日：2015-12-31

Applicant: Development Center for Biotechnology ,  DCB-USA LLC

Inventor： Chao-Pin Lee ,  Cheng-Chou Yu ,  Chi-Huey Wong ,  Chuan-Lung Hsu ,  Chun-Chung Lee ,  Shih-Hsien Chuang ,  Ta-Tung Yuan ,  Yi-Jen Chen ,  Yu-Chin Nieh

IPC: C07K1/107 ,  C07K1/08 ,  A61K39/395 ,  C07K16/18 ,  A61K47/68

CPC classification number: C07K1/1077 ,  A61K39/395 ,  A61K47/6803 ,  A61K47/6855 ,  A61K47/6889 ,  A61K49/0043 ,  A61K49/0058 ,  C07K1/08 ,  C07K16/18

Abstract: A method for specific linkage to a glycoprotein includes obtaining a glycoprotein having a monoglycan or diglycan attached thereto; producing a reactive functional group on a sugar unit on the glycoprotein; and coupling a linker or a payload to the reactive functional group on the glycoprotein.

公开(公告)号：US11384150B2

公开(公告)日：2022-07-12

申请号：US16467655

申请日：2017-12-13

Applicant: Development Center for Biotechnology ,  Tunghai University

Inventor： Shih-Hsien Chuang ,  Wei-Ting Chao ,  Wei-Ting Sun ,  Hui-Jan Hsu ,  Wun-Huei Lin

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  A61K38/00 ,  A61K45/06 ,  A61K39/00 ,  A61K39/395

Abstract: An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.

公开(公告)号：US10947316B2

公开(公告)日：2021-03-16

申请号：US16010251

申请日：2018-06-15

Applicant: Development Center for Biotechnology

Inventor： Chao-Pin Lee ,  Shih-Hsien Chuang ,  Chuan-Lung Hsu ,  Yi-Jen Chen ,  Yu-Chin Nieh ,  Win-Yin Wei ,  Chia-Cheng Wu

IPC: A61P35/00 ,  A61K47/68 ,  A61K49/00 ,  G01N33/574 ,  A61K47/64 ,  A61K47/65 ,  A61K31/337 ,  A61K31/5365 ,  C07K16/30 ,  A61K39/395 ,  C07K16/28

Abstract: An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab−(L−D)m, wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.

公开(公告)号：US20190106507A1

公开(公告)日：2019-04-11

申请号：US16010251

申请日：2018-06-15

Applicant: Development Center for Biotechnology

Inventor： Chao-Pin Lee ,  Shih-Hsien Chuang ,  Chuan-Lung Hsu ,  Yi-Jen Chen ,  Yu-Chin Nieh ,  Win-Yin Wei ,  Chia-Cheng Wu

IPC: C07K16/30 ,  A61P35/00 ,  A61K47/65 ,  A61K47/64 ,  A61K47/68

Abstract: An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab−(L−D)m, wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.

公开(公告)号：US20210015942A1

公开(公告)日：2021-01-21

申请号：US16244090

申请日：2019-01-09

Applicant: Development Center for Biotechnology

Inventor： Shih-Hsien Chuang ,  Chu-Bin Liao ,  Wei-Ting Sun ,  Chen-Hsien Liang ,  Wun-Huei Lin ,  Chun-Liang Lai ,  Her-Sheng Lin

IPC: A61K47/68 ,  C07K16/32 ,  A61P35/00

Abstract: An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.

公开(公告)号：US08999983B2

公开(公告)日：2015-04-07

申请号：US13689590

申请日：2012-11-29

Applicant: Taivex Therapeutics Corporation ,  Development Center for Biotechnology

Inventor： Jiann-Jyh Huang ,  Shih-Hsien Chuang ,  Ying-Shuan Eda Lee ,  Yu-Ling Huang ,  Johnson Lau

IPC: A61K31/5377 ,  C07D417/12 ,  C07D417/14 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D277/46

CPC classification number: A61K31/5377 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K45/06 ,  C07D277/46 ,  C07D417/12 ,  C07D417/14

Abstract: Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Such compounds disrupt Nek2/Hec1 binding and may be useful as chemotherapeutic agents for neoplastic diseases.

Abstract translation: 提供了用于调节Hec1 / Nek2相互作用的化合物，组合物和方法。 这种化合物破坏了Nek2 / Hec1结合，可能作为肿瘤疾病的化学治疗剂。

公开(公告)号：US11998613B2

公开(公告)日：2024-06-04

申请号：US17339747

申请日：2021-06-04

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Shih-Hsien Chuang ,  Wei-Ting Sun ,  Ying-Shuan Lailee ,  Chun-Liang Lai ,  Wun-Huei Lin ,  Win-Yin Wei ,  Shih-Chong Tsai ,  Cheng-Chou Yu ,  Chao-Yang Huang

IPC: A61K47/68 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K47/6851 ,  A61K47/545 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6889 ,  A61P35/00

Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

公开(公告)号：US11085062B2

公开(公告)日：2021-08-10

申请号：US16470807

申请日：2017-12-29

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Shih-Chong Tsai ,  Chun-Chung Lee ,  Meng-Sheng Lee ,  Ching-Yao Chen ,  Shih-Hsien Chuang ,  Yi-Jen Chen ,  Win-Yin Wei

IPC: C12P21/00 ,  A61K47/68 ,  C07K16/32

Abstract: A process for modifying glycoproteins is provided. The invention also provides a process for producing glycoprotein-payload conjugates, as well as the conjugates produced thereby.

公开(公告)号：US20200062738A1

公开(公告)日：2020-02-27

申请号：US16609639

申请日：2018-04-30

Applicant: Development Center for Biotechnology ,  National Yang-Ming University

Inventor： Cheng-Wen Wu ,  Erh-Hsuan Jiann Lin ,  Chi-Ying Huang ,  Jia-Ming Chang ,  Shih-Hsien Chuang ,  Hui-Jan Hsu ,  Wei-Wei Chen

IPC: C07D403/14 ,  A61P35/00 ,  C07D209/14 ,  C07D333/58 ,  C07D401/12 ,  C07D403/12 ,  C07D401/10 ,  C07D413/12 ,  C07D487/04 ,  C07D405/12 ,  C07D405/14 ,  C07D495/04

Abstract: A compound for inhibiting BMI-1/MCL-1 having a structure of Formula (I), wherein the various groups are as described. A pharmaceutical composition for treating cancer includes an effective amount of a compound of Formula (I).