公开(公告)号：US20240188899A1

公开(公告)日：2024-06-13

申请号：US18425393

申请日：2024-01-29

Applicant: Dexcom, Inc.

Inventor： Giovanni SPARACINO ,  Claudio COBELLI ,  Stefania GUERRA ,  Andrea FACCHINETTI ,  Michele SCHIAVON

IPC: A61B5/00 ,  A61B5/145 ,  G16H50/30

CPC classification number: A61B5/7275 ,  A61B5/14532 ,  A61B5/743 ,  A61B5/746 ,  G16H50/30 ,  A61B5/7405 ,  A61B5/7455

Abstract: A device for generating alerts for Hypo and Hyperglycemia Prevention from Continuous Glucose Monitoring (CGM) determines a dynamic risk based on both information of glucose level and a trend obtainable from a CGM signals. The device includes a display whose color depends on the DR (for example, red for high DR, green for low risk). When DR exceeds a certain threshold, alerts are generated to suggest the patient to pay attention to the current glucose reading and to its trend, both of which are shown on the display in numbers and symbols (e.g. an arrow with different slope or color).

公开(公告)号：US20230210474A1

公开(公告)日：2023-07-06

申请号：US18179594

申请日：2023-03-07

Applicant: Dexcom, Inc.

Inventor： Hari HAMPAPURAM ,  Anna Leigh DAVIS ,  Naresh C. BHAVARAJU ,  Apurv Ullas KAMATH ,  Claudio COBELLI ,  Giovanni SPARACINO ,  Andrea FACCHINETTI ,  Chiara ZECCHIN

IPC: A61B5/00 ,  A61B5/145

CPC classification number: A61B5/746 ,  A61B5/14532 ,  A61B5/0022 ,  A61B5/0004 ,  A61B5/7275 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/4848 ,  A61B5/4866 ,  A61B5/7221 ,  A61B5/002

Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.

公开(公告)号：US20230210412A1

公开(公告)日：2023-07-06

申请号：US18182444

申请日：2023-03-13

Applicant: Dexcom, Inc.

Inventor： Claudio COBELLI ,  Simone DEL FAVERO ,  Andrea FACCHINETTI ,  Giovanni SPARACINO

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1495 ,  G16H10/40 ,  G16H50/30

CPC classification number: A61B5/14532 ,  A61B5/1451 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7264 ,  A61B5/7289 ,  G16H10/40 ,  G16H50/30

Abstract: Continuous Glucose Monitoring (CGM) devices provide glucose concentration measurements in the subcutaneous tissue with limited accuracy and precision. Therefore, CGM readings cannot be incorporated in a straightforward manner in outcome metrics of clinical trials e.g. aimed to assess new glycaemic-regulation therapies. To define those outcome metrics, frequent Blood Glucose (BG) reference measurements are still needed, with consequent relevant difficulties in outpatient settings. Here we propose a “retrofitting” algorithm that produces a quasi continuous time BG profile by simultaneously exploiting the high accuracy of available BG references (possibly very sparsely collected) and the high temporal resolution of CGM data (usually noisy and affected by significant bias). The inputs of the algorithm are: a CGM time series; some reference BG measurements; a model of blood to interstitial glucose kinetics; and a model of the deterioration in time of sensor accuracy, together with (if available) a priori information (e.g. probabilistic distribution) on the parameters of the model. The algorithm first checks for the presence of possible artifacts or outliers on both CGM datastream and BG references, and then rescales the CGM time series by exploiting a retrospective calibration approach based on a regularized deconvolution method subject to the constraint of returning a profile laying within the confidence interval of the reference BG measurements. As output, the retrofitting algorithm produces an improved “retrofitted” quasi-continuous glucose concentration signal that is better (in terms of both accuracy and precision) than the CGM trace originally measured by the sensor. In clinical trials, the so-obtained retrofitted traces can be used to calculate solid outcome measures, avoiding the need of increasing the data collection burden at the patient level.

公开(公告)号：US20220313173A1

公开(公告)日：2022-10-06

申请号：US17808377

申请日：2022-06-23

Applicant: Dexcom, Inc.

Inventor： Giovanni SPARACINO ,  Claudio COBELLI ,  Stefania GUERRA ,  Andrea FACCHINETTI ,  Michele SCHIAVON

IPC: A61B5/00 ,  A61B5/145 ,  G16H50/30

Abstract: A device for generating alerts for Hypo and Hyperglycemia Prevention from Continuous Glucose Monitoring (CGM) determines a dynamic risk based on both information of glucose level and a trend obtainable from a CGM signals. The device includes a display whose color depends on the DR (for example, red for high DR, green for low risk). When DR exceeds a certain threshold, alerts are generated to suggest the patient to pay attention to the current glucose reading and to its trend, both of which are shown on the display in numbers and symbols (e.g. an arrow with different slope or color).