公开(公告)号：US09872873B2

公开(公告)日：2018-01-23

申请号：US14377047

申请日：2012-03-29

申请人： Dhiraj Khattar ,  Rajesh Khanna ,  Sanjay Motwani ,  Minakshi Garg ,  Vikas Chandel ,  Mukti Yadav ,  Vijay Kumar Kyama ,  Vikas Bhandari

发明人： Dhiraj Khattar ,  Rajesh Khanna ,  Sanjay Motwani ,  Minakshi Garg ,  Vikas Chandel ,  Mukti Yadav ,  Vijay Kumar Kyama ,  Vikas Bhandari

IPC分类号： A61K31/706 ,  A61K47/02 ,  A61K47/26 ,  A61K31/4184 ,  A61K9/19 ,  A61K9/00

CPC分类号： A61K31/706 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/4184 ,  A61K47/02 ,  A61K47/26

摘要： The present invention relates to a process of preparing a stable pharmaceutical composition of compounds which are susceptible to hydrolysis comprising a. Addition of required quantity of pharmaceutically acceptable lyophilization excipients optionally in Water for Injection in a formulation vessel; b. Addition of organic solvent to form a appropriate proportion of aqueous and organic solvent; c. Maintaining the temperature of the formulation vessel from the range −5±1° C. to −5±3° C.; d. Addition of required quantity of compound susceptible to hydrolysis to form a solution and lyophilizing the solution.

公开(公告)号：US20140378407A1

公开(公告)日：2014-12-25

申请号：US14377047

申请日：2012-03-29

申请人： Dhiraj Khattar ,  Rajesh Khanna ,  Sanjay Motwani ,  Minakshi Garg ,  Vikas Chandel ,  Mukti Yadav ,  Vijay Kumar Kyama ,  Vikas Bhandari

发明人： Dhiraj Khattar ,  Rajesh Khanna ,  Sanjay Motwani ,  Minakshi Garg ,  Vikas Chandel ,  Mukti Yadav ,  Vijay Kumar Kyama ,  Vikas Bhandari

IPC分类号： A61K31/706 ,  A61K47/02 ,  A61K47/26 ,  A61K31/4184 ,  A61K9/19

CPC分类号： A61K31/706 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/4184 ,  A61K47/02 ,  A61K47/26

摘要： The present invention relates to a process of preparing a stable pharmaceutical composition of compounds which are susceptible to hydrolysis comprising a. Addition of required quantity of pharmaceutically acceptable lyophilization excipients optionally in Water for Injection in a formulation vessel; b. Addition of organic solvent to form a appropriate proportion of aqueous and organic solvent; c. Maintaining the temperature of the formulation vessel from the range −5±1° C. to −5±3° C.; d. Addition of required quantity of compound susceptible to hydrolysis to form a solution and lyophilizing the solution.

摘要翻译： 本发明涉及一种制备易于水解的化合物的稳定药物组合物的方法，其包括a。 在配制容器中，任选地在注射用水中加入所需量的药学上可接受的冻干赋形剂; b。 加入有机溶剂形成适当比例的水和有机溶剂; C。 将制剂容器的温度保持在-5±1℃至-5±3℃的范围内。 d。 加入所需量的易水解的化合物形成溶液并冻干该溶液。

公开(公告)号：US20190183729A1

公开(公告)日：2019-06-20

申请号：US16285527

申请日：2019-02-26

申请人： Siva Prasad Reddy Sura ,  Surya Kumari Padala ,  Vikas Chandel ,  Arvind Gannimitta ,  Jayant Karajgi ,  Sivakumaran Meenakshisunderam

发明人： Siva Prasad Reddy Sura ,  Surya Kumari Padala ,  Vikas Chandel ,  Arvind Gannimitta ,  Jayant Karajgi ,  Sivakumaran Meenakshisunderam

IPC分类号： A61J1/14 ,  A61J1/10 ,  A61K31/4174 ,  A61K47/02 ,  B65B3/00 ,  B65B55/02

CPC分类号： A61J1/1468 ,  A61J1/10 ,  A61J1/1475 ,  A61K31/4174 ,  A61K47/02 ,  B65B3/003 ,  B65B55/027

摘要： The present invention relates to stable premix formulations for parenteral use and packaging for such formulations. The present invention relates to use of a single layer or multilayer film bags comprising polypropylene for packing premixed injectable formulations which remain stable during the storage period.The present invention relates to use of a single layer or multilayer film bags comprising polypropylene for packing dexmedetomidine premixed formulations. Such stable premixed formulations packed into a single layer or multilayer film bags comprising polypropylene are highly advantageous since they are ready-to-use, for example, in perioperative care of a subject in need thereof for sedation.

公开(公告)号：US20170128421A1

公开(公告)日：2017-05-11

申请号：US15348374

申请日：2016-11-10

申请人： Siva Prasad Reddy Sura ,  Surya Kumari Padala ,  Vikas Chandel ,  Arvind Gannimitta ,  Jayant Karajgi ,  Meenakshisunderam Sivakumaran

发明人： Siva Prasad Reddy Sura ,  Surya Kumari Padala ,  Vikas Chandel ,  Arvind Gannimitta ,  Jayant Karajgi ,  Meenakshisunderam Sivakumaran

IPC分类号： A61K31/4164 ,  A61J1/10

CPC分类号： A61K31/4174

摘要： The present invention relates to stable premix formulations for parenteral use and packaging for such formulations. The present invention relates to use of a single layer or multilayer film bags comprising polypropylene for packing premixed injectable formulations which remain stable during the storage period.The present invention relates to use of a single layer or multilayer film bags comprising polypropylene for packing dexmedetomidine premixed formulations. Such stable premixed formulations packed into a single layer or multilayer film bags comprising polypropylene are highly advantageous since they are ready-to-use, for example, in perioperative care of a subject in need thereof for sedation.