公开(公告)号：US20240016975A1

公开(公告)日：2024-01-18

申请号：US18373603

申请日：2023-09-27

申请人： DiFusion, Inc.

发明人： Derrick Johns ,  Joseph J. Crudden ,  Sriram Sankar

IPC分类号： A61L27/02 ,  A61L27/18 ,  A61L27/08 ,  A61K33/38 ,  A61K33/34 ,  A61K33/06 ,  A61K33/00 ,  A61K33/30

CPC分类号： A61L27/025 ,  A61L27/18 ,  A61L27/08 ,  A61K33/38 ,  A61K33/34 ,  A61K33/06 ,  A61K33/00 ,  A61K33/30 ,  A61L2300/102 ,  A61L2300/404 ,  A61L2430/10 ,  A61L2300/104

摘要： Anti-biofilm osseointegrating and/or tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are engineered to produce structures suitable as implants having a relatively high surface population of zeolite. Methods of producing the devices are also disclosed.

公开(公告)号：US20190298523A1

公开(公告)日：2019-10-03

申请号：US16369147

申请日：2019-03-29

申请人： DiFusion, Inc.

发明人： Joseph J. Crudden ,  Derrick Johns ,  Sriram Sankar

IPC分类号： A61F2/28 ,  A61L27/34 ,  A61L27/56 ,  A61F2/00

摘要： Anti-biofilm osseointegrating implantable devices are made by additive manufacturing. A powder formulation is made that includes a resin such as a polyarylether ketone such as PEEK, and a zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The powder formulation also may include a porogen to control the porosity of the resulting three-dimensional implant device. The devices, which are osseointegrating, may include metal-loaded zeolite so as to elute antimicrobial metal ions in a therapeutically effective amount when implanted into a body and exposed to bodily fluid.

公开(公告)号：US20210402052A1

公开(公告)日：2021-12-30

申请号：US17361582

申请日：2021-06-29

申请人： DiFusion, Inc.

发明人： Derrick Johns ,  Joseph J. Crudden ,  Sriram Sankar

IPC分类号： A61L27/02 ,  A61L27/18 ,  A61L27/08 ,  A61K33/38 ,  A61K33/34 ,  A61K33/30 ,  A61K33/06 ,  A61K33/00

摘要： Anti-biofilm osseointegrating and/or tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are engineered to produce structures suitable as implants having a relatively high surface population of zeolite. Methods of producing the devices are also disclosed.

公开(公告)号：US20200338238A1

公开(公告)日：2020-10-29

申请号：US16923495

申请日：2020-07-08

申请人： DiFusion, Inc.

发明人： Joseph J. Crudden ,  Derrick Johns

IPC分类号： A61L27/54 ,  A61L27/44 ,  A61L27/10 ,  A61L27/18 ,  A61L27/56

摘要： Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.

公开(公告)号：US20200338237A1

公开(公告)日：2020-10-29

申请号：US16923486

申请日：2020-07-08

申请人： DiFusion, Inc.

发明人： Joseph J. Crudden ,  Derrick Johns

IPC分类号： A61L27/54 ,  A61L27/44 ,  A61L27/10 ,  A61L27/18 ,  A61L27/56

摘要： Methods of post-loading ceramic particles with antimicrobial metal cations are disclosed. In certain embodiments, the post-loaded particles are zeolites, wherein the zeolites have been incorporated into a resin and the combination is used as an implantable device. In certain embodiments, the polymer is a thermoplastic polymer such as polyaryletheretherketone (PEEK). In certain embodiments, the source of antimicrobial activity includes ion-exchangeable cations contained in a zeolite. In certain embodiments, disclosed are methods of imparting antimicrobial activity to devices by controlling the delivery of certain cations through ion-exchange via a zeolite incorporated in the device.

公开(公告)号：US20200315802A1

公开(公告)日：2020-10-08

申请号：US16905110

申请日：2020-06-18

申请人： DiFusion, Inc.

发明人： Joseph J. Crudden ,  Derrick Johns ,  Sriram Sankar

IPC分类号： A61F2/28 ,  A61L27/34 ,  A61L27/56 ,  A61F2/00

摘要： Anti-biofilm osseointegrating implantable devices are made by additive manufacturing. A powder formulation is made that includes a resin such as a polyarylether ketone such as PEEK, and a zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The powder formulation also may include a porogen to control the porosity of the resulting three-dimensional implant device. The devices, which are osseointegrating, may include metal-loaded zeolite so as to elute antimicrobial metal ions in a therapeutically effective amount when implanted into a body and exposed to bodily fluid.

公开(公告)号：US20190298886A1

公开(公告)日：2019-10-03

申请号：US16369141

申请日：2019-03-29

申请人： DiFusion, Inc.

发明人： Joseph J. Crudden ,  Derrick Johns ,  Sriram Sankar

IPC分类号： A61L27/54 ,  A61L27/56

摘要： Anti-biofilm osseointegrating implantable devices that can elute therapeutic ions such as silver are provided by powder coating implantable substrates such as metal substrates. The polymer includes a polyarylether ketone such as PEEK, and zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The devices, when implanted into a body and exposed to bodily fluid, may elute antimicrobial metal ions in a therapeutically effective amount.