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    Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments
    5.
    发明授权
    Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments 失效
    甾族酯在17位酯化并在21位硫酯化，其制备方法及其用作药物

    公开(公告)号：US4427671A

    公开(公告)日：1984-01-24

    申请号：US397715

    申请日：1982-07-13

    申请人： Dieran R. Torossian ,  Gilbert G. Aubard ,  Claude P. Roux ,  Agnes G. Grouhel

    发明人： Dieran R. Torossian ,  Gilbert G. Aubard ,  Claude P. Roux ,  Agnes G. Grouhel

    IPC分类号： A61K31/57 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  C07J31/00 ,  A61K31/56 ,  C07J7/00

    CPC分类号： C07J31/006 ,  Y10S514/826

    摘要： Compounds of formula: ##STR1## wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally mono- or polysubstituted by alkyl radicals having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms or halogen, T and U, independently of each other, represent hydrogen atoms or together form a double bond, V is a hydrogen atom or a methyl group at the .alpha.-position, W is a hydrogen atom or a halogen atom at the .alpha.-position, X is a hydroxy group at the .beta.-position and Y is a hydrogen atom or X and Y may together represent an oxygen atom, and Z.sub.1 is a hydrogen atom, a methyl group at the .alpha.- or .beta.-position, while Z.sub.2 is a hydrogen atom, or Z.sub.1 and Z.sub.2 together form a methylene group. These compounds have anti-inflammatory activity.

    摘要翻译： 其中A和B各自独立地表示具有1至6个碳原子的直链或支链烷基或任选被1至6个碳原子的烷基单取代或多取代的苯基， 6个碳原子，具有1至6个碳原子的烷氧基或卤素，T和U彼此独立地表示氢原子或一起形成双键，V是氢原子或α-位上的甲基， W是α位上的氢原子或卤素原子，X是β位上的羟基，Y是氢原子，X和Y可以一起代表氧原子，Z1是氢原子， 甲基在α或β-位，而Z 2是氢原子，或Z 1和Z 2一起形成亚甲基。 这些化合物具有抗炎活性。

    Process for the preparation of steroids
    6.
    发明授权
    Process for the preparation of steroids 失效
    制备类固醇的方法

    公开(公告)号：US4269778A

    公开(公告)日：1981-05-26

    申请号：US96153

    申请日：1979-11-20

    申请人： Dieran R. Torossian ,  Gilbert G. Aubard

    发明人： Dieran R. Torossian ,  Gilbert G. Aubard

    IPC分类号： C07J31/00 ,  C07J5/00

    CPC分类号： C07J31/006

    摘要： Process for the preparation of steroids.The steroid 21-thioesters are prepared by preparing the corresponding sulphonates in acetonic suspension and by reacting this suspension directly with a thiocarboxylate.Preparation of synthesis intermediates.

    摘要翻译： 制备类固醇的方法。 类固醇21-硫酯通过在丙酮悬浮液中制备相应的磺酸盐并通过使该悬浮液与硫代羧酸盐直接反应来制备。 合成中间体的制备。