公开(公告)号：US20110200666A1

公开(公告)日：2011-08-18

申请号：US12833155

申请日：2010-07-09

申请人： Dirk Teichmüller ,  Monika Beyer ,  Michael Sacher

发明人： Dirk Teichmüller ,  Monika Beyer ,  Michael Sacher

IPC分类号： A61K9/127 ,  A61K8/73 ,  A61Q17/04

CPC分类号： A61Q17/04 ,  A61K8/14 ,  A61K8/73 ,  A61K8/731 ,  A61K8/732 ,  A61K2800/83 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12

摘要： To provide a UV protection agent for topical application to the skin or hair with a very high UV filter substance concentration and good adhesion to skin and hair in accordance with the invention there is proposed a UV protection agent having at least one UV filter substrate encapsulated in a vesicle carrier system, wherein the UV protection agent is characterised in that the at least one UV filter substance encapsulated in the vesicular carrier system is soluble in oil and the vesicular carrier system comprises vesicles which are made up of hydrophobised polysaccharides and are of a particle size of between 10 and 1000 nm and have a positive surface charge with a zeta potential in the range of between 1 and 150 mV. In addition there is proposed the use of such a UV protection agent in suitable cosmetic and/or pharmaceutical formulations.

摘要翻译： 为了提供一种紫外线防护剂，用于根据本发明以非常高的UV过滤物质浓度和对皮肤和毛发的良好粘合剂局部施用于皮肤或头发，提出了一种UV保护剂，其具有封装在 一种囊泡载体系统，其中所述紫外线防护剂的特征在于，包封在囊状载体体系中的至少一种紫外线过滤物质可溶于油，并且囊泡载体体系包含由疏水多糖组成并且为颗粒的囊泡 尺寸在10和1000nm之间，并且具有在1和150mV范围内的ζ电位的正表面电荷。 此外，提出了在合适的化妆品和/或药物制剂中使用这种UV保护剂。

公开(公告)号：US20080318325A1

公开(公告)日：2008-12-25

申请号：US11922366

申请日：2006-06-28

申请人： Gabriel Blume ,  Michael Sacher ,  Dirk Teichmueller ,  Katinka Jung

发明人： Gabriel Blume ,  Michael Sacher ,  Dirk Teichmueller ,  Katinka Jung

IPC分类号： G01N33/92 ,  G01N24/00

CPC分类号： G01N24/10 ,  Y10T436/24

摘要： A method for the determination of the morphological integrity of a membrane of lipid vesicles, such as liposomes, using electron spin resonance (ESR) spectroscopy including the steps of: a) labeling the lipid vesicles with an ESR-active probe; b) producing a sample by introducing a quantity of the labeled lipid vesicles into a test medium; c) producing a positive control by introducing a quantity of the labeled lipid vesicles into a control medium and optionally a negative control by introducing a quantity of the ESR-active probe into the test medium; d) obtaining ESR spectra of the controls and the sample; and e) comparing ESR spectra of the sample and controls to determine relative morphological integrity. Morphological integrity of lipid vesicles may be quantitatively determined in the test medium by obtaining difference spectra produced using the spectra of the sample and of the positive and/or negative control.

摘要翻译： 一种使用电子自旋共振（ESR）光谱法测定脂质囊泡膜脂质囊膜形态完整性的方法，包括以下步骤：a）用ESR活性探针标记脂质囊泡; b）通过将一定量的标记的脂质囊泡引入到测试介质中来生产样品; c）通过将一定量的ESR活性探针引入测试培养基中，将一定数量的标记的脂质囊泡引入对照培养基和任选的阴性对照中来产生阳性对照; d）获得对照和样品的ESR光谱; 和e）比较样品和对照的ESR光谱以确定相对形态学完整性。 脂质囊泡的形态完整性可以通过获得使用样品和阳性和/或阴性对照的光谱产生的差异光谱在测试培养基中定量测定。

公开(公告)号：US20070098662A1

公开(公告)日：2007-05-03

申请号：US10567631

申请日：2004-08-04

申请人： Gabriele Blume ,  Michael Sacher ,  Dirk Teichmuller

发明人： Gabriele Blume ,  Michael Sacher ,  Dirk Teichmuller

IPC分类号： A61K8/73

CPC分类号： A61K9/1272 ,  A61K8/14 ,  A61K8/22 ,  A61K8/315 ,  A61K8/68 ,  A61K8/70 ,  A61K9/0014 ,  A61Q19/00

摘要： A cosmetic composition containing from about 1% to about 50% by weight of membrane-forming sphingolipids and/or galactolipids and about 5% to about 50% by weight of a fluorocarbon or fluorocarbon mixture charged with oxygen. Surprisingly, it has been shown that the use of membrane-forming sphingolipids and/or galactolipids as transport vesicles or for the formation of transport vesicles for a fluorocarbon or fluorocarbon mixture charged with oxygen results in excellent transport of oxygen through the stratum corneum of the skin and the epidermis in a manner which is far superior to known transport systems.

摘要翻译： 含有约1％至约50％重​​量的成膜鞘脂和/或半乳糖脂和约5％至约50％重​​量的带有氧气的碳氟化合物或碳氟化合物混合物的化妆品组合物。 令人惊奇的是，已经表明，使用成膜鞘脂和/或半乳糖脂作为运输囊泡或用于形成用于含有氧气的碳氟化合物或碳氟化合物的运输囊泡导致氧气通过皮肤角质层的良好转运 和表皮的方式远远优于已知的运输系统。