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公开(公告)号:US20080305073A1
公开(公告)日:2008-12-11
申请号:US11631328
申请日:2005-07-04
申请人: Domenico G. Barone , Marco E. Bianchi , Enrico M. Bucci , Silvano Fumero , Margherita Valente , Roberto Sapio , Domenica Musumeci
发明人: Domenico G. Barone , Marco E. Bianchi , Enrico M. Bucci , Silvano Fumero , Margherita Valente , Roberto Sapio , Domenica Musumeci
IPC分类号: A61K38/20 , C07H21/00 , C07H21/04 , A61K38/17 , A61K48/00 , A61F2/06 , A61M25/00 , C12Q1/02 , A61K31/7088 , A61K39/395 , A61K38/19
CPC分类号: A61K31/713 , C12N15/115 , C12N2310/16 , C12N2310/3181 , C12N2310/52
摘要: The present invention relates to the use of synthetic double-stranded nucleic acid or nucleic acid analogue molecules with a bent shape structure for the prevention and treatment of pathologies induced directly or indirectly by the HMGB1 protein.
摘要翻译: 本发明涉及具有弯曲形状结构的合成双链核酸或核酸类似物分子用于预防和治疗由HMGB1蛋白直接或间接诱导的病理学的用途。