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公开(公告)号:US20060135426A1
公开(公告)日:2006-06-22
申请号:US11304446
申请日:2005-12-14
申请人: Dominique Bridon , Benoit L' Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique Bridon , Benoit L' Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号: C07K14/605 , A61K38/27
CPC分类号: C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译: 公开了改进的促胰岛素肽。 修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。 修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。 缀合物可以在体内或离体形成。 施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。