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公开(公告)号:US20060135426A1
公开(公告)日:2006-06-22
申请号:US11304446
申请日:2005-12-14
申请人: Dominique Bridon , Benoit L' Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique Bridon , Benoit L' Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号: C07K14/605 , A61K38/27
CPC分类号: C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译: 公开了改进的促胰岛素肽。 修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。 修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。 缀合物可以在体内或离体形成。 施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。
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公开(公告)号:US20060058235A1
公开(公告)日:2006-03-16
申请号:US11215967
申请日:2005-08-30
申请人: Dominique Bridon , Benoit L'Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique Bridon , Benoit L'Archeveque , Alan Ezrin , Darren Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号: A61K38/22
CPC分类号: C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
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公开(公告)号:US20090093408A1
公开(公告)日:2009-04-09
申请号:US12221554
申请日:2008-08-01
申请人: Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号: A61K38/16 , C07K14/00 , C07K14/76 , C07K14/765
CPC分类号: C07K14/57563 , A61K38/38 , A61K47/62 , A61K47/643
摘要: A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a react group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity.
摘要翻译: 描述了一种在体内保护肽免受肽酶活性的方法,所述肽由2-50个氨基酸组成且具有C末端和N末端以及C末端氨基酸和N-末端氨基酸 。 在该方法的第一步中,通过将反应基团连接到C末端氨基酸,N末端氨基酸或位于N末端和C末端之间的氨基酸来修饰肽, 使得修饰的肽能够在体内与血液成分上的反应性官能团形成共价键。 在下一步骤中,在反应性基团和血液成分上的反应性官能团之间形成共价键以形成肽 - 血液成分缀合物,从而保护所述肽免受肽酶活性。 该方法的最后步骤包括分析肽 - 血液成分缀合物的稳定性,以评估肽对肽酶活性的保护。
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公开(公告)号:US06887849B2
公开(公告)日:2005-05-03
申请号:US10288340
申请日:2002-11-04
申请人: Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
CPC分类号: C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译: 公开了改进的促胰岛素肽。 修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。 修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。 缀合物可以在体内或离体形成。 施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。
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公开(公告)号:US08080516B2
公开(公告)日:2011-12-20
申请号:US11170967
申请日:2005-06-29
申请人: Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk LeBlanc , Serge St. Pierre
发明人: Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk LeBlanc , Serge St. Pierre
IPC分类号: A61K38/22
CPC分类号: C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译: 公开了改进的促胰岛素肽。 修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。 修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。 缀合物可以在体内或离体形成。 施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。
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公开(公告)号:US06329336B1
公开(公告)日:2001-12-11
申请号:US09623618
申请日:2000-09-05
申请人: Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号: A01N3718
CPC分类号: C07K14/005 , A61K38/00 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译: 公开了改进的促胰岛素肽。 修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。 修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。 缀合物可以在体内或离体形成。 施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。
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公开(公告)号:US06593295B2
公开(公告)日:2003-07-15
申请号:US09876388
申请日:2001-06-06
申请人: Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号: A01N3718
CPC分类号: C07K14/005 , A61K38/00 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译: 公开了改进的促胰岛素肽。 修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。 修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。 缀合物可以在体内或离体形成。 施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。
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公开(公告)号:US06514500B1
公开(公告)日:2003-02-04
申请号:US09657332
申请日:2000-09-07
申请人: Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique P. Bridon , Benoit L'Archeveque , Alan M. Ezrin , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号: A61K39385
CPC分类号: C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译: 公开了改进的促胰岛素肽。 修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。 修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。 缀合物可以在体内或离体形成。 施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。
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9.
公开(公告)号:US08093206B2
公开(公告)日:2012-01-10
申请号:US11304446
申请日:2005-12-14
申请人: Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号: A61K38/22
CPC分类号: C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译: 公开了改进的促胰岛素肽。 修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。 修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。 缀合物可以在体内或离体形成。 施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。
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10.
公开(公告)号:US08084414B2
公开(公告)日:2011-12-27
申请号:US11215967
申请日:2005-08-30
申请人: Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
发明人: Dominique P. Bridon , Benoit L'Archeveque , Darren L. Holmes , Anouk Leblanc , Serge St. Pierre
IPC分类号: A61K38/22
CPC分类号: C07K14/005 , A61K38/00 , A61K47/643 , C07K14/57563 , C07K14/605 , C12N2740/16122
摘要: Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
摘要翻译: 公开了改进的促胰岛素肽。 修饰的促胰岛素肽能够形成肽酶稳定的促胰岛素肽。 修饰的促胰岛素肽能够与一种或多种血液成分形成共价键以形成缀合物。 缀合物可以在体内或离体形成。 施用修饰的肽以治疗患有糖尿病和其他相关疾病的人。
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