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    Process for producing wet ribavirin pellets
    2.
    发明申请
    Process for producing wet ribavirin pellets 审中-公开
    生产湿利巴韦林颗粒的方法

    公开(公告)号：US20050075297A1

    公开(公告)日：2005-04-07

    申请号：US10765134

    申请日：2004-01-28

    申请人： Donald Kerrish ,  John Bergeron ,  Larry Augsburger

    发明人： Donald Kerrish ,  John Bergeron ,  Larry Augsburger

    IPC分类号： A61K9/16 ,  A61K31/7056 ,  A61K31/7072

    CPC分类号： A61K9/1694 ,  A61K31/7056

    摘要： A process for producing wet ribavirin pellets is provided in order to make pharmaceutical dosages of ribavirin. The process is particularly useful as an alternative method for preparing pharmaceutical dosages of ribavirin that reduces the amount of ribavirin dust that is produced during the manufacturing process and allows for greater control of dissolution rates. According to the preferred embodiments, this method is accomplished through mixing ribavirin with at least one excipient into a uniform mixture, forming the mixture into a granulated mass by adding a wetting agent, shaping said granulated mass into soluble particles and drying the flowable particles. The process enables Ribavirin pharmaceutical pellets to be mixed with a binder and disintegrant to form a uniform mixture.

    摘要翻译： 提供了生产湿利巴韦林丸的方法，以制备利巴韦林的药物剂量。 该方法作为制备利巴韦林的药物剂量的替代方法是特别有用的，其减少了在制造过程中产生的利巴韦林粉尘的量并且允许更好地控制溶解速率。 根据优选的实施方案，该方法通过将利巴韦林与至少一种赋形剂混合成均匀的混合物来实现，通过加入润湿剂将所述混合物形成粒状物质，将所述粒化物质成形成可溶性颗粒并干燥可流动颗粒。 该方法使利巴韦林药物颗粒与粘合剂和崩解剂混合以形成均匀的混合物。