公开(公告)号：US08609400B2

公开(公告)日：2013-12-17

申请号：US12662930

申请日：2010-05-12

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。 该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。

公开(公告)号：US08420381B2

公开(公告)日：2013-04-16

申请号：US12926277

申请日：2010-11-05

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

IPC分类号： A01N1/02 ,  C12M1/36

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。 该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。 在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。 在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。 可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。 防止过度加压防止或减少对血管内皮衬里和器官组织的损害。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。

公开(公告)号：US08445260B2

公开(公告)日：2013-05-21

申请号：US13137383

申请日：2011-08-10

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Douglas Schein ,  Stanley Harris ,  Dennis Steibel ,  Richard Fraser ,  Dickon Isaacs

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Douglas Schein ,  Stanley Harris ,  Dennis Steibel ,  Richard Fraser ,  Dickon Isaacs

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

公开(公告)号：US08268612B2

公开(公告)日：2012-09-18

申请号：US13137386

申请日：2011-08-10

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Douglas Schein ,  Dickon Isaacs

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Douglas Schein ,  Dickon Isaacs

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。 该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。 在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。 在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。 可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。 防止过度加压防止或减少对血管内皮衬里和器官组织的损害。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。

公开(公告)号：US07824848B2

公开(公告)日：2010-11-02

申请号：US10617130

申请日：2003-07-11

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

公开(公告)号：US06673594B1

公开(公告)日：2004-01-06

申请号：US09645525

申请日：2000-08-25

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

IPC分类号： A01N102

CPC分类号： A01N1/02 ,  A01N1/0247 ,  A01N1/0273

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of the organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。

公开(公告)号：US08431385B2

公开(公告)日：2013-04-30

申请号：US12929410

申请日：2011-01-21

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

公开(公告)号：US08349551B2

公开(公告)日：2013-01-08

申请号：US12926276

申请日：2010-11-05

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J. Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein

IPC分类号： A01N1/00

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。 通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。 在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。

公开(公告)号：US08318415B2

公开(公告)日：2012-11-27

申请号：US12910308

申请日：2010-10-22

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein ,  Christopher G. Curtis

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Dennis J Steibel ,  Richard Fraser ,  Stanley Harris ,  Douglas Schein ,  Christopher G. Curtis

IPC分类号： A01N1/00

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。 该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。 该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。 通过用正常体温温度下的医用流体例如氧合交联血红蛋白的碳酸氢盐医疗液灌注器官，恢复高能量核苷酸（例如ATP）水平来恢复器官存活力。 在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。 在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。 可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。 防止过度加压防止或减少对血管内皮衬里和器官组织的损害。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。

公开(公告)号：US08962303B2

公开(公告)日：2015-02-24

申请号：US13137385

申请日：2011-08-10

申请人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

发明人： Donald R. Owen ,  David C. Kravitz ,  John Brassil ,  Kelvin G. M. Brockbank ,  Andrew Burroughs ,  Dickon Isaacs ,  Douglas Schein

IPC分类号： A01N1/02

CPC分类号： G06F17/30876 ,  A01N1/02 ,  A01N1/0247 ,  A01N1/0273 ,  H04L67/02

摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

摘要翻译： 器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。 其他装置包括器官输送器，器官盒和器官诊断装置。 在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压预防和紧急流量截止。 在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。 可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。 可以自动监测器官的活力，优选通过监测医用流体灌注液的特性。 可以使用控制程序自动控制灌注过程。